Results 91 to 100 of about 28,141 (278)

Investigation of the relationship between Fusobacterium nucleatum presence and inflammatory mediator expression in Kazakhstani patients with colorectal cancer

Frontiers in Microbiology
ObjectivesFusobacterium nucleatum has been recognized as a critical microorganism contributing to the development and progression of colorectal cancer (CRC). However, the role of F.
Gulmira Kulmambetova, Botakoz Kurentay, Alua Gusmaulemova, Dina Bayanbek, Meiram Mamlin, Saule Khamzina, Sanzhar Shalekenov, Arman Kozhakhmetov   +7 more
doaj   +1 more source

Competitive SELEX Strategy for High‐Affinity Aptamer Isolation and Enhanced Biosensing

Small, EarlyView.
A novel competitive SELEX strategy was developed to isolate high‐affinity aptamers by using a lower‐affinity competitor during the selection process. This approach enabled the identification of an aptamer with exceptional binding affinity, significantly improving target detection sensitivity.
Jiuxing Li, Jiaxuan Xiao, Jimmy Gu, Zhen Zhang, Yingfu Li   +4 more
wiley   +1 more source

Construction and Characterization of a Single-Chain Variable Fragment Antibody Library against Fusobacterium nucleatum

, 2012
Farhan Khan placed second in the International Association for Dental Research/Unilever Hatton Competition in the Senior Basic Science Research Category representing Canada, while presenting the research contained in this dissertation.

core  

A Serum‐Resistant Plasma Membrane Probe for Real‐Time Visualization of Pathogen‐Induced Epithelial Barrier Dysfunction

Small, EarlyView.
PM580 selectively activates at the plasma membrane while remaining minimally responsive to serum albumin, enabling serum‐compatible, surface‐confined imaging for 24 h, unlike conventional probes that rapidly internalize and lose membrane contrast.
Yujeong Choi, Sunhwa Jung, Dong Min Kang, Lizaveta Gotina, Minji Kim, Eunmi Ha, Sungsu Lim, Ae Nim Pae, Jaeson Jang, Evgeni Ponimaskin, Ja‐Hyun Baik, Sun‐Joon Min, Yun Kyung Kim   +12 more
wiley   +1 more source

Periodontal microbiology and microbial etiology of periodontal diseases: Historical concepts and contemporary perspectives

Periodontology 2000, EarlyView., 2023
Abstract This narrative review summarizes the collective knowledge on periodontal microbiology, through a historical timeline that highlights the European contribution in the global field. The etiological concepts on periodontal disease culminate to the ecological plaque hypothesis and its dysbiosis‐centered interpretation.
Georgios N. Belibasakis, Daniel Belstrøm, Sigrun Eick, Ulvi K. Gursoy, Anders Johansson, Eija Könönen   +5 more
wiley   +1 more source

Enrichment of T: A→A: T substitutions in the TP53 gene in esophageal carcinoma with high Fusobacterium burden

Scientific Reports
Exogenous lifestyle and environmental risk factors impact mutation burden in both benign and cancerous tissues. Moreover, interactions between the mucosa-associated microbiome and such genotoxic changes have been implicated in several cancer types.
Tomomitsu Tahara, Takuya Shijimaya, Jumpei Yamazaki, Tsubasa Shimogama, Sanshiro Kobayashi, Naohiro Nakamura, Yu Takahashi, Takashi Tomiyama, Toshiro Fukui, Tomoyuki Shibata, Makoto Naganuma   +10 more
doaj   +1 more source

Fusobacterium Nucleatum and Meningitis

Scholars Journal of Medical Case Reports
Fusobacterium nucleatum is a rare cause of meningitis in adults, yet it is associated with significant morbidity and mortality. We present a case of meningitis due to Fusobacterium nucleatum in a 28-year-old male with a history of head trauma two years prior, recurrent pneumococcal meningitis, and a cerebrospinal fluid leak. Initial cerebrospinal fluid
Ngindu M. Filston, Khaleq Khalid, Dibwe K. Glodi, Kamate Oumar   +3 more
openaire   +1 more source

Oral microbiome and homeostatic regulation of periodontal health: From dysbiosis to precision intervention

VIEW, EarlyView.
Periodontal homeostasis is maintained by coordinated interactions between the oral microbiome and host. Dysbiosis disrupts this ecological balance and contributes to periodontal disease, whereas multi‐omics, artificial intelligence, and microbiome‐based interventions provide emerging opportunities for precision diagnosis, ecological restoration, and ...
Xu Liu, Lei Meng, Wenzhu Song, Peiyu Wang, Bin Liu, Shihui Liu, Qi He, Bing Sun, Wanheng Li, Zhiwei Guan, Rui Dong, Qiang Feng   +11 more
wiley   +1 more source

Periodontal diseases and adverse pregnancy outcomes. Present and future

Periodontology 2000, EarlyView., 2023
Abstract For more than two decades the possible association between periodontal diseases and adverse pregnancy outcomes has been extensively evaluated. Numerous observational, intervention, and mechanistic studies have offered valuable information on this topic.
Yiorgos A. Bobetsis, Mark Ide, Mervi Gürsoy, Phoebus N. Madianos   +3 more
wiley   +1 more source

Impact of Metformin and Diabetes on Tumor Response to Total Neoadjuvant Therapy in Advanced Rectal Cancer: A Multicenter Retrospective Cohort Study

Asia-Pacific Journal of Clinical Oncology, EarlyView.
In advanced rectal cancer patients receiving total neoadjuvant therapy (TNT), overall tumor response did not differ by diabetes status or metformin use. However, among diabetic patients, metformin use was associated with higher overall complete response rates. These findings suggest a potential benefit of metformin in enhancing TNT response in diabetic
Sergei Bedrikovetski, Mahima Raju, Tracy Fitzsimmons, Ishraq Murshed, Timothy J. Price, Michael Penniment, Sudarsha Selva‐Nayagam, Tarik Sammour   +7 more
wiley   +1 more source