Results 101 to 110 of about 21,540 (276)

Impact of Metformin and Diabetes on Tumor Response to Total Neoadjuvant Therapy in Advanced Rectal Cancer: A Multicenter Retrospective Cohort Study

Asia-Pacific Journal of Clinical Oncology, EarlyView.
In advanced rectal cancer patients receiving total neoadjuvant therapy (TNT), overall tumor response did not differ by diabetes status or metformin use. However, among diabetic patients, metformin use was associated with higher overall complete response rates. These findings suggest a potential benefit of metformin in enhancing TNT response in diabetic
Sergei Bedrikovetski, Mahima Raju, Tracy Fitzsimmons, Ishraq Murshed, Timothy J. Price, Michael Penniment, Sudarsha Selva‐Nayagam, Tarik Sammour   +7 more
wiley   +1 more source

Fusobacterium nucleatum Infection Drives Glutathione Depletion in Gastric Cancer: Integrated Multi-Omics and Experimental Validation

Microorganisms
The colonization of Fusobacterium nucleatum (F. nucleatum) in the microenvironment of gastric cancer (GC) is closely associated with tumor progression, but its impact on host metabolic remodeling remains unclear.
Siru Nie, Yuehua Gong, Ang Wang, Rui Guo, Xiaohui Chen, Yuan Yuan   +5 more
doaj   +1 more source

Fusobacterium Nucleatum-Induced Tumor Mutation Burden Predicts Poor Survival of Gastric Cancer Patients

, 2022
Co-infection of Helicobacter pylori and Fusobacterium nucleatum is a microbial biomarker for poor prognosis of gastric cancer patients. Fusobacterium nucleatum is associated with microsatellite instability and the accumulation of mutations in colorectal ...
Chin Li, Yung-Yu Hsieh, Wen-Lin Kuo, Shui-Yi Tung, Wan-Ting Hsu   +4 more
core   +1 more source

Fusobacterium nucleatumand colorectal cancer: A review

World Journal of Gastrointestinal Oncology, 2018
Fusobacterium nucleatum (F. nucleatum) is a Gram-negative obligate anaerobe bacterium in the oral cavity and plays a role in several oral diseases, including periodontitis and gingivitis. Recently, several studies have reported that the level of F.
Shang, Fu-Mei, Liu, Hong-Li
openaire   +2 more sources

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, EarlyView.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

Fusobacterium nucleatum upregulates the immune inhibitory receptor PD-L1 in colorectal cancer cells via the activation of ALPK1

Gut Microbes
Fusobacterium nucleatum is a Gram-negative oncobacterium that is associated with colorectal cancer. The molecular mechanisms utilized by F. nucleatum to promote colorectal tumor development have largely focused on adhesin-mediated binding to the tumor ...
Coco Duizer, Moniek Salomons, Merel van Gogh, Sanne Gräve, Freke A. Schaafsma, Maaike J. Stok, Merel Sijbranda, Raghuvandhanan Kumarasamy Sivasamy, Rob J. L. Willems, Marcel R. de Zoete   +9 more
doaj   +1 more source

Microbiome–Driven Carcinogenesis and Circulating Microbial Signals in Genitourinary Cancers

Cancer Science, EarlyView.
Experimental BBN models link gut microbial metabolism and diet‐microbiome interactions to urothelial carcinogenesis, while circulating extracellular vesicle‐associated bacterial DNA signals may reflect tumor immune contexture and immune checkpoint inhibitor outcomes in urothelial and renal cell carcinoma.
Atsunari Kawashima, Kentaro Jingushi, Takuro Saito, Toshihiro Uemura, Akinaru Yamamoto, Nesrine Sassi, Hiromu Horitani, Shunsuke Inoguchi, Yuki Horibe, Yu Ishizuya, Takuji Hayashi, Yoshiyuki Yamamoto, Norio Nonomura   +12 more
wiley   +1 more source

Fusobacterium nucleatum regulation of neutrophil transcription

, 2011
Wright HJ, Chapple ILC, Matthews JB, Cooper PR. Fusobacterium nucleatum regulation of neutrophil transcription. J Periodont Res 2010; doi: 10.1111/j.1600-0765.2010.01299.x.
Chapple, Iain; id_orcid, I. L. C. Chapple, Matthews, John, H. J. Wright, Wright, Helen, J. B. Matthews, P. R. Cooper, Cooper, Paul   +7 more
core   +1 more source

Could Periodontal Disease through Periopathogen Fusobacterium nucleatum Be an Aggravating Factor for Gastric Cancer?

, 2020
Periodontal disease affects the supporting tissues of the teeth, being a chronic inflammatory disease caused by specific microorganisms from subgingival biofilm.
Valeriu Marin Șurlin, Dan Ionuț Gheonea, Flavia Mirela Nicolae, Andreea Cristiana Didilescu, Bogdan Silviu Ungureanu, Petra Șurlin, Ștefan Pătrașcu   +6 more
core   +1 more source

A Comparison of Endodontic Microbiomes Associated With Symptomatic and Asymptomatic Apical Periodontitis by Next‐Generation Sequencing

International Endodontic Journal, EarlyView.
ABSTRACT Aim This cross‐sectional study aimed to compare the endodontic microbiome assessed from root canals of teeth associated with either symptomatic or asymptomatic apical periodontitis and analysed by 16S rDNA gene sequencing. Methodology 60 teeth presenting clinical and radiographic signs of symptomatic or asymptomatic apical periodontitis (n ...
David Donnermeyer, Edgar Schäfer, Daniel Hagenfeld, Benjamin Ehmke, Karola Prior, Dag Harmsen, Madgalena Ibing, Sebastian Bürklein, Thomas Gerhard Wolf, Johannes Matern   +9 more
wiley   +1 more source