Results 121 to 130 of about 17,845 (237)

Fusobacterium nucleatum Promotes the Growth and Metastasis of Colorectal Cancer by Activating E‐Cadherin/Krüppel‐Like Factor 4/Integrin α5 Signaling in a Calcium‐Dependent Manner

MedComm
Gut microbiota and integrins are known to contribute to colorectal cancer (CRC), but whether they interact has been unclear. Here, we provided evidence that Fusobacterium nucleatum upregulated integrin α5 (ITGA5) in CRC in both human patients and murine ...
Xuebing Yan, Xiao Qu, Jiaxin Wang, Ling Lu, Wenjuan Wu, Jingxian Mao, Donglin Li, Ying Wang, Qing Wei, Jianqiang Liu   +9 more
doaj   +1 more source

Periodontitis and Rheumatoid Arthritis—Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
Periodontitis and rheumatoid arthritis are linked via the two‐hit model whereby early periodontal inflammation can lead to autoantibody production capable of interacting with inflamed synovial tissues. Subsequent systemic inflammation can exacerbate the periodontal inflammatory response and bacterial dysbiosis leading to further autoantibody production
Mark Bartold, Chia Wei Cheah, Rathna Devi Vaithilingam   +2 more
wiley   +1 more source

Periodontitis and Adverse Pregnancy Outcomes: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This narrative review aims to describe mechanisms linking periodontal diseases in pregnancy with adverse pregnancy outcomes. ABSTRACT Periodontal diseases, including both gingivitis and periodontitis, occur commonly among pregnant individuals. Both gingivitis and periodontitis are associated with adverse pregnancy outcomes (APOs) such as early ...
Gregory C. Valentine, Yiorgos A. Bobetsis, Benjamin C. Shayo, Peter Milgrom, Phoebus N. Madianos   +4 more
wiley   +1 more source

Next Generation Smart Implant Surfaces: Engineering Multifunctional Antimicrobial, Immunomodulatory and Regenerative Interfaces

Journal of Periodontal Research, EarlyView.
Natural‐inspired nano‐textured implant surfaces can be functionalised to modulate macrophage polarisation and local immune responses. This bioactive control promotes improved tissue integration and healing outcomes. ABSTRACT Dental implants rely on a stable and functional interface between the implant surface, surrounding tissues, and the oral ...
Roberto S. Pessoa, Lauren E. Steele, Mehvish Mumtaz, Denver P. Linklater, Neil M. O'Brien‐Simpson, Vladimir Baulin, Peter Kingshott, Roy Judge, Alastair J. Sloan, Elena P. Ivanova   +9 more
wiley   +1 more source

The rise and evolving role of Fusobacterium nucleatum subspecies

Current Research in Microbial Sciences
This review examines the classification, distribution, and detection methods of Fusobacterium nucleatum subspecies, focusing on their distinct roles in health and disease. The evolution of F. nucleatum classification is traced from early to modern protein-based and genomic methods, such as 16S rRNA and next generation sequencing and matrix-assisted ...
Marietta Wolf, Thorsten Steinberg, Konstantin Johannes Scholz, Anne Kruse, Sama Rezasoltani, Georg Conrads, Ali Al-Ahmad, Fabian Cieplik   +7 more
openaire   +3 more sources

Oral Phageome as Potential Modulators of Periodontal Dysbiosis. A Systematic Review

Oral Diseases, EarlyView.
ABSTRACT Introduction The oral phageome, comprising bacteriophages inhabiting the oral cavity, has been proposed as a potential modulator of periodontal health and disease. This systematic review synthesizes current evidence on interactions between bacteriophages, key periodontal bacteria, and the host in periodontitis.
Marco Bonilla, Sara El‐Amrani, Pablo Galindo‐Moreno, Francisco Mesa   +3 more
wiley   +1 more source

Fusobacterium nucleatum [PDF]

, 2020
openaire   +1 more source

Periodontitis‐Associated Bacteria and Their Connection to Proinflammatory Biomarkers in Periodontal Pockets: A Clinical Microbiological Study

Oral Diseases, EarlyView.
ABSTRACT Background This study examines the relationship between the microbial load of selected periodontitis‐associated bacteria (PAB) and proinflammatory biomarkers in gingival crevicular fluid (GCF) from patients with periodontitis. Methods GCF and subgingival biofilm samples were collected from the deepest periodontal pocket of each quadrant of 515
Nils Werner, Charlotte Wetzel, Vinay Pitchika, Burkhard Summer, Christina Ern, Richard Heym, Thomas Spinell, Falk Schwendicke, Matthias Folwaczny, Caspar Victor Bumm   +9 more
wiley   +1 more source

Association Between Periodontitis and Respiratory Diseases: A Systematic Umbrella Meta‐Analysis

Oral Diseases, EarlyView.
ABSTRACT Aim This study aimed to evaluate the association between periodontitis and respiratory diseases using an umbrella meta‐analysis. Methods Meta‐analyses (MAs) reporting odds ratios (OR) and mean differences (MD) for the association between periodontitis and respiratory diseases of COVID‐19, chronic obstructive pulmonary disease (COPD), asthma ...
Shahen Hiwa Omer, Mohammed Khalid Mahmood, Sarhang Sarwat Gul, Yad Mariwan Mohammed Amin, Romain Lan   +4 more
wiley   +1 more source

Porphyromonas gingivalis GroEL exacerbates orthotopic allograft transplantation vasculopathy via impairment of endothelial cell function

Molecular Oral Microbiology, EarlyView.
Abstract Orthotopic allograft transplantation (OAT) is a significant approach to addressing organ failure. However, persistent immune responses to the allograft affect chronic rejection, which induces OAT vasculopathy (OATV) and organ failure. Porphyromonas gingivalis can infiltrate remote organs via the bloodstream, thereby intensifying the severity ...
Chien‐Sung Tsai, Chun‐Yao Huang, Yi‐Ting Tsai, Chun‐Ming Shih, Ze‐Hao Lai, Chen‐Wei Liu, Yi‐Wen Lin, Feng‐Yen Lin   +7 more
wiley   +1 more source