Results 81 to 90 of about 33,412 (306)

Term Stillbirth Caused by Oral Fusobacterium nucleatum [PDF]

Obstetrics & Gynecology, 2010
Intrauterine infection is a recognized cause of adverse pregnancy outcome, but the source of infection is often undetermined. We report a case of stillbirth caused by Fusobacterium nucleatum that originated in the mother's mouth.A woman with pregnancy-associated gingivitis experienced an upper respiratory tract infection at term, followed by stillbirth
Yiping W, Han, Yann, Fardini, Casey, Chen, Karla G, Iacampo, Victoria A, Peraino, Jaime M, Shamonki, Raymond W, Redline   +6 more
openaire   +2 more sources

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

Cell Surface Fibroblast Activation Protein-2 (Fap2) of Fusobacterium nucleatum as a Vaccine Candidate for Therapeutic Intervention of Human Colorectal Cancer: An Immunoinformatics Approach

Vaccines, 2023
Colorectal cancer (CRC) is one of the most common cancers and is the second-highest in cancer-related deaths worldwide. The changes in gut homeostasis and microbial dysbiosis lead to the initiation of the tumorigenesis process.
Somrita Padma, Ritwik Patra, Parth Sarthi Sen Gupta, S. Panda, M. Rana, Suprabhat Mukherjee   +5 more
semanticscholar   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

A Modified Method Incorporating Multiplex PCR Reveals Fusobacterium Prevalence in Southern Chinese Population and Its Correlations in Cancers

Microbial Biotechnology
Fusobacterium, a gram‐negative anaerobic bacillus in mouth, gastrointestinal tract and elsewhere, has long been considered as opportunistic pathogen. Increasing evidence indicate the association of Fusobacterium with human diseases, especially cancer ...
Tingting Shen, Jiarui Liang, Xuyu Li, Xiaoxie Xu, Liqiong Li, Yinjuan Xu, Shanshui Zeng, Bingyu Li, Hui Li, Mengyao Hu, Lang Zhou, Siqi Yan, Ya Zhang, Ziwei Zhou, Huaaishi Liang, Shulei Chen, Zhikun Liang, Congrong Wang, Hongwei Zhou, Dongxin Zhang   +19 more
doaj   +1 more source

Fusobacterium nucleatum induces oxaliplatin resistance by inhibiting ferroptosis through E-cadherin/β-catenin/GPX4 axis in colorectal cancer.

Free Radical Biology & Medicine
Fusobacterium (F.) nucleatum is a carcinogenesis microbiota in colorectal cancer (CRC). Growing evidence shows that F. nucleatum contributes to chemoresistance.
Bowen Li, Zixian Wei, Zhiyue Wang, Fangqi Xu, Jinhua Yang, Baiqiang Lin, Yu Chen, Hubin Wenren, Lingli Wu, Xiao Guo, Yang Liu, Yunwei Wei   +11 more
semanticscholar   +1 more source

Fusobacterium nucleatum promotes colorectal cancer cells adhesion to endothelial cells and facilitates extravasation and metastasis by inducing ALPK1/NF-κB/ICAM1 axis

Gut microbes, 2022
Metastasis is the leading cause of death for colorectal cancer (CRC) patients, and the spreading tumor cells adhesion to endothelial cells is a critical step for extravasation and further distant metastasis. Previous studies have documented the important
Ying Zhang, Lu Zhang, Sheng Zheng, Mengjie Li, Chaochao Xu, Dingjiacheng Jia, Yadong Qi, Tongyao Hou, Lan Wang, Boya Wang, Aiqing Li, Shujie Chen, Jianmin Si, W. Zhuo   +13 more
semanticscholar   +1 more source

FomA‐Containing Outer Membrane Vesicles of Fusobacterium Nucleatum Facilitate Bladder Cancer Lymphatic Metastasis via IL‐6‐Dependent M2b Macrophage Polarization

Advanced Science, EarlyView.
Urinary Fusobacterium nucleatum–derived outer membrane vesicles are shown to promote bladder cancer lymphatic metastasis. The vesicle protein FomA activates TLR2/NF‐κB signaling in tumor cells, induces IL‐6 secretion, and drives M2b macrophage polarization and VEGF‐C–dependent lymphangiogenesis, revealing a microbiota‐driven mechanism linking tumor ...
Wentai Shangguan, Weijia Li, Wenxue Huang, Jilin Wu, Yao Yu, Yiyao Huang, Lin Yang, Ming Xie, Qishen Yang, Jun Zheng, Yuexuan Zhu, Qi Sun, Biao Li, Leqian Li, Zongwei Wang, Jie Zhao, Peng Wu, Bisheng Cheng   +17 more
wiley   +1 more source

Exploring the role of Fusobacterium nucleatum in colorectal cancer: implications for tumor proliferation and chemoresistance

Cell Communication and Signaling
Fusobacterium nucleatum (Fn) has been extensively studied for its connection to colorectal cancer (CRC) and its potential role in chemotherapy resistance.
Leila Dadgar-Zankbar, Zahra Elahi, A. Shariati, A. Khaledi, Shabnam Razavi, Amin Khoshbayan   +5 more
semanticscholar   +1 more source

Outer Membrane Proteins of Fusobacterium nucleatum Fev1 [PDF]

Microbiology, 1986
Outer membrane enriched material from six strains of Fusobacterium nucleatum was analysed by SDS-PAGE. The protein profiles of all the strains were dominated by proteins with molecular masses of about 40 kDa, and a very high degree of homology in relation to apparent molecular masses was observed.
V, Bakken, H B, Jensen
openaire   +2 more sources