Results 111 to 120 of about 5,149 (183)

A Systematic Framework to Derive N-glycan Biosynthesis Process and the Automated Construction of Glycosylation Networks [PDF]

, 2016
published_or_final_versio
Akoi-Kinoshita, K, Ching, WK, Hashimoto, N, HOU, W, QIU, Y   +4 more
core   +1 more source

Double knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC

BMC Biotechnology, 2007
Background Antibody-dependent cellular cytotoxicity (ADCC) is greatly enhanced by the absence of the core fucose of oligosaccharides attached to the Fc, and is closely related to the clinical efficacy of anticancer activity in humans in vivo ...
Shitara Kenya, Iida Shigeru, Wakitani Masako, Inoue Miho, Mori Katsuhiro, Imai-Nishiya Harue, Satoh Mitsuo   +6 more
doaj   +1 more source

Pathway landscape and regulatory networks of epigenetically modified Breast Cancer genes [PDF]

Epigenetic changes are a key regulator of gene expression in different cancer histotypes. After investigating the differentially expressed genes upon treatment with a demethylating agent, e.g.
Capobianco, Enrico, Cinti, Caterina, El Baroudi, Mariama, La Sala, Dario   +3 more
core  

Core fucosylation of IL-2RB is required for natural killer cell homeostasis

Cell Reports
Summary: Natural killer (NK) cell homeostasis and effector functions require context-dependent signaling via numerous receptors, including the interleukin-15 receptor (IL-15R).
Harrison Sudholz, Xiangpeng Meng, Hae-Young Park, Zihan Shen, Iva Nikolic, Joseph Cursons, Ethan D. Goddard-Borger, Iona S. Schuster, Christopher E. Andoniou, Mariapia A. Degli-Esposti, Nichollas E. Scott, Michael Chopin, Jai Rautela, Sebastian Scheer, Nicholas D. Huntington   +14 more
doaj   +1 more source

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis [PDF]

, 2017
Multiple sclerosis (MS), a chronic disorder of the central nervous system and common cause of neurological disability in young adults, is characterized by moderate but complex risk heritability.
Angelakopoulou, Aspasia, Baranzini, Sergio E., Barkhof, Frederik, Caillier, Stacy J., Cree, Bruce A. C., Galwey, Nicholas, Gass, Achim, George, Michaela F., Geurts, Jeroen J.G., Gibson, Rachel A., Gomez, Refujia, Goodin, Douglas S., Green, Ari J., Guerrero, Rosa, Hall, Leslie, Hauser, Stephen L., Johnson, Michael R., Kappos, Ludwig, Kragt, Jolijn, Lincoln, Robin R., Lindberg, Raija L.P., Matthews, Paul M., Mousavi, Hourieh, Naegelin, Yvonne, Oksenberg, Jorge R., Okuda, Darin T., Pelletier, Daniel, Polman, Chris H., Prinjha, Rab K., Qualley, Pamela, Radue, Ernst-Wilhelm, Richardson, Jill C., Sombekke, Madeleine, Uitdehaag, Bernard M.G., Vrenken, Hugo, Wang, Joanne, Waubant, Emmanuelle   +36 more
core  

The Multifaceted Role of FUT8 in Tumorigenesis: From Pathways to Potential Clinical Applications

International Journal of Molecular Sciences
FUT8, the sole glycosyltransferase responsible for N-glycan core fucosylation, plays a crucial role in tumorigenesis and development. Aberrant FUT8 expression disrupts the function of critical cellular components and triggers the abnormality of tumor signaling pathways, leading to malignant transformations such as proliferation, invasion, metastasis ...
Meng Shi, Xin-Rui Nan, Bao-Qin Liu
openaire   +2 more sources

Retour sur 50 ans de coopération franco-allemande : le traité de l'Élysée à l'épreuve du temps [PDF]

, 2013
Texte publié dans le Bulletin de l'ADEAF no 123 / mars 2014 (p. 44-51)Der fünfzigste Jahrestag der Unterzeichnung des Vertrages über die deutsch-französische Zusammenarbeit (Élysée-Vertrag) bietet Gelegenheit, die deutsch-französischen Beziehungen einer ...
Charrier, Landry
core   +1 more source

FUT8: AN EMERGING DRIVER OF METASTASIS

Pakistan Journal of Medicine and Dentistry
This critical research periodical is mainly based on critical review of research article titled “A Systems Biology Approach Identifies FUT8 as a Driver of Melanoma Metastasis” published in Cancer Cell by Agrawal et al1. Glycosylation is the distinct cell and microenvironment relatedmechanism establishing glycosidic linkages with major nutrients by the ...
Zil-e-Rubab PJMD, Hussain Shah
openaire   +1 more source

Cloning of FUT8 gene and characterization of its expression in human cell lines [PDF]

, 2018
Altered glycosylation is a universal feature of cancer cells, and certain glycans are well-known markers of tumor progression. Glycans are involved in fundamental molecular and cell biology processes occurring in cancer, such as tumor cell dissociation ...
Freitas, Érica Nair André de
core  

Testing a measurement model of multidimensional intrinsic motivation in studying for examination [PDF]

, 2012
Intrinsic motivation is seen as a stronger driver for academic success compared to extrinsic motivation. This study proposed a comprehensive framework for intrinsic motivation by incorporating five different theories in a measurement model. The reason is
Elias, Habibah, Mohd Noah, Sidek, Roslan, Samsilah, Syed Mustafa, Syarifah Muzlia   +3 more
core