Results 91 to 100 of about 4,088 (175)

Fentanyl Promotes Breast Cancer Cell Stemness and Epithelial-Mesenchymal Transition by Upregulating α1, 6-Fucosylation via Wnt/β-Catenin Signaling Pathway

Frontiers in Physiology, 2017
Cancer pain is a common and severe complication of human breast cancer, and relieving pain is fundamental strategy in the treatment. Fentanyl, as an opioid analgesic, is widely used in breast cancer patients. However, little is known about its effects on
Hong-Fang Yang, Ming Yu, Hui-Dan Jin, Jia-Qi Yao, Zhi-Li Lu, Iddrisu B. Yabasin, Qiu Yan, Qing-Ping Wen   +7 more
doaj   +1 more source

Core fucosylation of IL-2RB is required for natural killer cell homeostasis

Cell Reports
Summary: Natural killer (NK) cell homeostasis and effector functions require context-dependent signaling via numerous receptors, including the interleukin-15 receptor (IL-15R).
Harrison Sudholz, Xiangpeng Meng, Hae-Young Park, Zihan Shen, Iva Nikolic, Joseph Cursons, Ethan D. Goddard-Borger, Iona S. Schuster, Christopher E. Andoniou, Mariapia A. Degli-Esposti, Nichollas E. Scott, Michael Chopin, Jai Rautela, Sebastian Scheer, Nicholas D. Huntington   +14 more
doaj   +1 more source

Double knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC

BMC Biotechnology, 2007
Background Antibody-dependent cellular cytotoxicity (ADCC) is greatly enhanced by the absence of the core fucose of oligosaccharides attached to the Fc, and is closely related to the clinical efficacy of anticancer activity in humans in vivo ...
Shitara Kenya, Iida Shigeru, Wakitani Masako, Inoue Miho, Mori Katsuhiro, Imai-Nishiya Harue, Satoh Mitsuo   +6 more
doaj   +1 more source

The Dual Role and Clinical Potential of Core Fucosylation in Liver Diseases

Shengwu huaxue yu shengwu wuli jinzhan
Core fucosylation, catalyzed exclusively by fucosyltransferase 8 (FUT8), is an evolutionarily conserved post-translational modification that has emerged as a central regulatory hub linking liver homeostasis, chronic disease progression, and malignant ...
LEI Zi-Han, XU Hui-Min, ZHAO De-Zhi, GUO Yong-Hong, DU Hao-Qi   +4 more
doaj   +1 more source

Clinicopathological characteristics of colorectal cancer patients according to FUT8 expression.

, 2018
Clinicopathological characteristics of colorectal cancer patients according to FUT8 expression.
Hirokazu Okayama (727077), Tomoyuki Momma (5485286), Masaru Noda (1595053), Shotaro Fujita (5485268), Motonobu Saito (237122), Shinji Ohki (5485292), Wataru Sakamoto (214289), Keita Aoto (5485271), Hisahito Endo (5485280), Shun Chida (5485289), Takeshi Tada (5485277), Takahiro Nakajima (61561), Mai Ashizawa (5485274), Katsuharu Saito (197101), Koji Kono (142779), Yasuhide Kofunato (5485295), Tomohiro Kikuchi (5485283)   +16 more
core   +1 more source

Roles of core fucosylation modification in immune system and diseases

Cell Insight
Core fucosylation, catalyzed by α1,6-fucosyltransferase (FUT8), is an important N-glycosylation modification process that attaches a fucose residue via an α1,6-linkage to the core N-acetylglucosamine of N-glycans in mammals.
Qiu Pan, Xiao-Lian Zhang
doaj   +1 more source

Activity of α 1,6-fucosyltransferase (FUT8) is reduced by depletion of oligosaccharyltransferase subunits

Glycobiology
Abstract Alpha-1,6-fucosyltransferase (FUT8) transfers fucose to the innermost GlcNAc residue of N-glycans, forming the core fucose structure. Core fucose critically regulates the functions of various glycoproteins and is associated with several diseases, including chronic obstructive pulmonary disease and cancer.
Seita Tomida, Takahiro Yamasaki, Daisuke Kohda, Yasuhiko Kizuka   +3 more
openaire   +2 more sources

Cloning of FUT8 gene and characterization of its expression in human cell lines [PDF]

, 2018
Altered glycosylation is a universal feature of cancer cells, and certain glycans are well-known markers of tumor progression. Glycans are involved in fundamental molecular and cell biology processes occurring in cancer, such as tumor cell dissociation ...
Freitas, Érica Nair André de
core  

Intron positions shared by S. frugiperda fut8 (inumberl) and with fut8 genes identified in chordata (inumberc).

, 2014
IS: Intronic Sequence.(X): Presence of lepidopteran intron insertion site.(+): Presence of chordata intron insertion site.(*) The gene is truncated and the 5′ exon is missing.Intron positions shared by S.
François Monjaret (647590), Sylvie Juliant (647588), Marie-Luce Violet (647592), Anne Harduin-Lepers (647589), Martine Duonor-Cérutti (647595), Annick Ozil (647594), Béatrice Catieau (647591), Pierre Cérutti (647593)   +7 more
core   +1 more source

FUT8 functions in lineage commitment in the human embryo.

We measured total transcription in the inner cell mass (ICM) and the trophectoderm (TE) of the human embryo to understand the mechanisms underlying TE commitment. We describe here discovery of FUT8 as a lineage commitment cooperating factor in embryonic stem cells of the human embryo. 
openaire   +2 more sources