Results 91 to 100 of about 616 (125)
Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion
Advanced ScienceGlycosylation, the covalent attachment of glycans to proteins, lipids, and RNAs, is fundamental in regulating diverse biological processes. Glycosylation patterns are aberrantly altered in the tumor microenvironment and closely associated with tumor ...
Yuting Cao +8 more
doaj +1 more source
Regulatory Mechanisms of FUT8 Activity and Expression in Cells
Trends in Glycoscience and Glycotechnologyopenaire +1 more source
Highly Glycosylated Mucins and FUT8 in Ulcerative Colitis
Trends in Glycoscience and Glycotechnologyopenaire +1 more source
FUT8 Alpha-(1,6)-Fucosyltransferase in Cancer [PDF]
International Journal of Molecular Sciences, 2021 Aberrant glycosylation is a universal feature of cancer cells that can impact all steps in tumour progression from malignant transformation to metastasis and immune evasion. One key change in tumour glycosylation is altered core fucosylation. Core fucosylation is driven by fucosyltransferase 8 (FUT8), which catalyses the addition of α1,6-fucose to the ...
Emma Scott +2 more
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The Multifaceted Role of FUT8 in Tumorigenesis: From Pathways to Potential Clinical Applications
International Journal of Molecular SciencesFUT8, the sole glycosyltransferase responsible for N-glycan core fucosylation, plays a crucial role in tumorigenesis and development. Aberrant FUT8 expression disrupts the function of critical cellular components and triggers the abnormality of tumor signaling pathways, leading to malignant transformations such as proliferation, invasion, metastasis ...
Baoqin Liu
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Effect and Mechanism Analysis of Pig FUT8 Gene on Resistance to Escherichia coli F18 Infection
International Journal of Molecular Sciences, 2022 Post-weaning diarrhea caused by enterotoxigenic Escherichia coli F18 (E. coli F18) causes significant economic losses for pig producers. Fucosyltransferase 8 (FUT8) is a glycosyltransferase that catalyzes core fucosylation; however, its role in mediating
Wenbin Bao, Shenglong Wu
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A Systems Biology Approach Identifies FUT8 as a Driver of Melanoma Metastasis
Cancer Cell, 2017 Association of aberrant glycosylation with melanoma progression is based mainly on analyses of cell lines. Here we present a systems-based study of glycomic changes and corresponding enzymes associated with melanoma metastasis in patient samples.
David Fenyo +2 more
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Association of Fucosyltransferase 8 (FUT8) Polymorphism Thr267Lys With Pulmonary Emphysema [PDF]
Journal of Human Genetics, 2011 The fucosyltransferase 8 gene (FUT8) encodes an enzyme that transfers fucose to the innermost N-acetylglucosamine unit of N-glycan chains. Recent study showed that fut8-deficient mice develop pathological and physiological phenotypes resembling pulmonary emphysema (PE). The role of FUT8 in human PE is not known.
Takeo Ishii +2 more
exaly +3 more sources
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FUT8 Remodeling of EGFR Regulates Epidermal Keratinocyte Proliferation During Psoriasis Development
Journal of Investigative Dermatology, 2021α-(1,6)-fucosyltransferase 8 (FUT8) is implicated in the pathogenesis of several malignancies, but its role in psoriasis is poorly understood. In this study, we show that FUT8 remodeling of EGFR plays a critical role in the development of psoriasis phenotypes.
Pi-Hui Liang, Fu-Yu Wu
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