Results 81 to 90 of about 616 (125)

Schematic illustration of the correlation between animal fut8 gene phylogeny, intron gain/loss and intron position (gene organization).

, 2014
This analysis was carried out by considering only the intron insertion sites in the fut8 gene sequences encoding the conserved region of FUT8 proteins, between i3l and the stop codon.
François Monjaret (647590), Sylvie Juliant (647588), Marie-Luce Violet (647592), Anne Harduin-Lepers (647589), Martine Duonor-Cérutti (647595), Annick Ozil (647594), Béatrice Catieau (647591), Pierre Cérutti (647593)   +7 more
core   +1 more source

Structure-based prioritization of marine natural products as candidate FUT8 binders

In Silico Research in Biomedicine
Protein glycosylation is one of the most common post-translational modifications and plays an important role in maintaining protein structure and function. Aberrant glycosylation can alter the structural profile of glycoproteins in colorectal cancer (CRC)
Khandu Wadhonkar, Faaiza Siddiqi, Aurelia Rughetti, Mirza S Baig   +3 more
doaj   +1 more source

The Dual Role and Clinical Potential of Core Fucosylation in Liver Diseases

Shengwu huaxue yu shengwu wuli jinzhan
Core fucosylation, catalyzed exclusively by fucosyltransferase 8 (FUT8), is an evolutionarily conserved post-translational modification that has emerged as a central regulatory hub linking liver homeostasis, chronic disease progression, and malignant ...
LEI Zi-Han, XU Hui-Min, ZHAO De-Zhi, GUO Yong-Hong, DU Hao-Qi   +4 more
doaj   +1 more source

Immunohistochemical staining with Fut8 and lectin-histochemical staining with LCA in typical gastric tumor tissues and adjacent non-tumor tissues.

, 2014
(A) Immunohistochemical staining with Fut8 in tumor cells (200×), the expression of Fut8 is weakly positive. (B) Immunohistochemical staining with Fut8 in non-tumor gastric cells (200×), the expression of Fut8 is strongly positive.
Xin-Yun Xu (551338), Meng Fang (473455), Chang-Hong Yi (551339), Yun-Peng Zhao (551337), Jun Ji (82053), Chun-Fang Gao (5658838), Xing Gu (551340), Ping-Ting Zhou (551341), Qing You (494016), Cheng Cheng (68821), Hao Wang (39217)   +10 more
core   +1 more source

Roles of core fucosylation modification in immune system and diseases

Cell Insight
Core fucosylation, catalyzed by α1,6-fucosyltransferase (FUT8), is an important N-glycosylation modification process that attaches a fucose residue via an α1,6-linkage to the core N-acetylglucosamine of N-glycans in mammals.
Qiu Pan, Xiao-Lian Zhang
doaj   +1 more source

The expression of FUT8 mRNA in multiple cohorts of colorectal cancer.

, 2018
(A) FUT8 mRNA expression was significantly upregulated in primary tumors compared to normal colon mucosa. (B) In five independent datasets of colorectal cancer, higher levels of FUT8 mRNA expression were consistently observed in tumors with wild-type p53
Hirokazu Okayama (727077), Tomoyuki Momma (5485286), Masaru Noda (1595053), Shotaro Fujita (5485268), Motonobu Saito (237122), Shinji Ohki (5485292), Wataru Sakamoto (214289), Keita Aoto (5485271), Hisahito Endo (5485280), Shun Chida (5485289), Takeshi Tada (5485277), Takahiro Nakajima (61561), Mai Ashizawa (5485274), Katsuharu Saito (197101), Koji Kono (142779), Yasuhide Kofunato (5485295), Tomohiro Kikuchi (5485283)   +16 more
core   +1 more source

Exploiting human fucosyltransferase 8 allostery with a covalent inhibitor for core fucosylation suppression

Nature Communications
Core fucosylation, catalyzed by fucosyltransferase 8 (FUT8), plays critical roles in cancer progression, immune evasion, and drug resistance, making it a compelling therapeutic target.
Jiheng Jiang, Dongyang He, Mengyu Ke, Jinhua Qin, Guang Yang, Biao Yu, Jing Wang, Pengfei Fang   +7 more
doaj   +1 more source

cFUT8 promotes liver cancer progression by miR-548c/FUT8 axis [PDF]

Signal Transduction and Targeted Therapy, 2021
Chong Li, Zhuoyuan Xin, Luyun He, Jing Ning, Kaisu Lin, Jiahui Pan, Jagannatha Rao, Guoqing Wang, Hong Zhu   +8 more
openaire   +3 more sources

Effects of miR-122 and miR-34a on FUT8 and ALDOA 3′UTRs in a luciferase reporter assay.

, 2013
For each experiment, HeLa cells were seeded in 96 plates (six replicates for each condition) and they were then co-transfected with either miR-122 or miR-34a mimics and with empty pMiR-Report, with pMiR-Report containing downstream FUT8 3′UTR (pMiR ...
Ugo Soffientini (468675), Cinzia Bernardi (468674), Francesco Piacente (468676), Michela G. Tonetti (468677)   +3 more
core   +1 more source

FUT8 functions in lineage commitment in the human embryo.

We measured total transcription in the inner cell mass (ICM) and the trophectoderm (TE) of the human embryo to understand the mechanisms underlying TE commitment. We describe here discovery of FUT8 as a lineage commitment cooperating factor in embryonic stem cells of the human embryo. 
openaire   +2 more sources