Results 71 to 80 of about 616 (125)

Systematic strategy for the development of glycosyltransferase inhibitors: diversity-oriented synthesis of FUT8 inhibitors

Glycans control various biological processes, depending on their structures. Particularly, core fucose, formed by α1,6-fucosyltransferase (FUT8), has a substantial influence on multiple biological processes. In this study, we investigated the development
Manabe, Yoshiyuki, Hizume, Koki, Hurtado-Guerrero, Ramón, Kamad, Yoshihiro, Kamada, Yoshihiro, Takakura, Yohei, Hurtado-Guerrer, Ramón, Fukase, Koichi, Takamatsu, Shinji, Miyoshi, Eiji   +9 more
core   +1 more source

Advances in cancer research on FUT8 molecular mechanisms and clinical applications

International Journal of Surgery
Fucosyltransferase 8 (FUT8) catalyzes core fucosylation, a critical post-translational modification influencing cellular processes. Aberrant core fucosylation is linked to tumor progression, including proliferation, metastasis, and immune evasion. This review integrates the transcriptional and post-transcriptional regulation of FUT8, its interactions ...
Qiancheng Ma, Yan Liu, Qing Fan, Xinqing Zhu, Deyong Yang, Ziqi Zhao   +5 more
openaire   +3 more sources

Analysis of intron positions shared with S. frugiperda fut8 (inumberl) in arthropoda and chordata orthologs fut8 genes.

, 2014
IS: intronic sequence, Nb: number. The intron phase was defined as follows: phase 0 introns are inserted between two codons; phase 1 introns are inserted after the first nucleotide of the codon, and phase 2 introns are inserted between the second and the
François Monjaret (647590), Sylvie Juliant (647588), Marie-Luce Violet (647592), Anne Harduin-Lepers (647589), Martine Duonor-Cérutti (647595), Annick Ozil (647594), Béatrice Catieau (647591), Pierre Cérutti (647593)   +7 more
core   +1 more source

Core fucosylation regulates the ovarian response via FSH receptor during follicular development

Journal of Advanced Research
Introduction: Ovarian low response to follicle-stimulating hormone (FSH) causes infertility featuring hypergonadotropic hypogonadism, ovarian failure, and/or defective ovarian response.
Tiantong Wang, Zhiwei Zhang, Changduo Qu, Wanli Song, Ming Li, Xiaoguang Shao, Tomohiko Fukuda, Jianguo Gu, Naoyuki Taniguchi, Wenzhe Li   +9 more
doaj   +1 more source

Characterizing human α-1,6-fucosyltransferase (FUT8) substrate specificity and structural similarities with related fucosyltransferases [PDF]

, 2020
Mammalian Asn-linked glycans are extensively processed as they transit the secretory pathway to generate diverse glycans on cell surface and secreted glycoproteins.
Wang, Lai-Xi, Zong, Guanghui, Ramiah, Annapoorani, Moremen, Kelley W, Boruah, Bhargavi M, Bosman, Gerlof P, Wood, Zachary A, Kadirvelraj, Renuka, Yang, Jeong-Yeh, Li, Chao, Liu, Lin, Boons, Geert-Jan, Afd Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery, Sub Chemical Biology and Drug Discovery   +14 more
core  

Fentanyl Promotes Breast Cancer Cell Stemness and Epithelial-Mesenchymal Transition by Upregulating α1, 6-Fucosylation via Wnt/β-Catenin Signaling Pathway

Frontiers in Physiology, 2017
Cancer pain is a common and severe complication of human breast cancer, and relieving pain is fundamental strategy in the treatment. Fentanyl, as an opioid analgesic, is widely used in breast cancer patients. However, little is known about its effects on
Hong-Fang Yang, Ming Yu, Hui-Dan Jin, Jia-Qi Yao, Zhi-Li Lu, Iddrisu B. Yabasin, Qiu Yan, Qing-Ping Wen   +7 more
doaj   +1 more source

Activity of α 1,6-fucosyltransferase (FUT8) is reduced by depletion of oligosaccharyltransferase subunits

Glycobiology
Abstract Alpha-1,6-fucosyltransferase (FUT8) transfers fucose to the innermost GlcNAc residue of N-glycans, forming the core fucose structure. Core fucose critically regulates the functions of various glycoproteins and is associated with several diseases, including chronic obstructive pulmonary disease and cancer.
Seita Tomida, Takahiro Yamasaki, Daisuke Kohda, Yasuhiko Kizuka   +3 more
openaire   +2 more sources

Representative images of immunohistochemistry for FUT8 and p53 expression in colorectal cancer.

, 2018
(A) FUT8 protein expression in colon carcinoma [T] and adjacent colon mucosa [N]. (B) FUT8 was not expressed by non-neoplastic colon mucosal cells. (C) FUT8 staining was typically found in cytoplasm of tumor cells.
Hirokazu Okayama (727077), Tomoyuki Momma (5485286), Masaru Noda (1595053), Shotaro Fujita (5485268), Motonobu Saito (237122), Shinji Ohki (5485292), Wataru Sakamoto (214289), Keita Aoto (5485271), Hisahito Endo (5485280), Shun Chida (5485289), Takeshi Tada (5485277), Takahiro Nakajima (61561), Mai Ashizawa (5485274), Katsuharu Saito (197101), Koji Kono (142779), Yasuhide Kofunato (5485295), Tomohiro Kikuchi (5485283)   +16 more
core   +1 more source

Core fucosylation of IL-2RB is required for natural killer cell homeostasis

Cell Reports
Summary: Natural killer (NK) cell homeostasis and effector functions require context-dependent signaling via numerous receptors, including the interleukin-15 receptor (IL-15R).
Harrison Sudholz, Xiangpeng Meng, Hae-Young Park, Zihan Shen, Iva Nikolic, Joseph Cursons, Ethan D. Goddard-Borger, Iona S. Schuster, Christopher E. Andoniou, Mariapia A. Degli-Esposti, Nichollas E. Scott, Michael Chopin, Jai Rautela, Sebastian Scheer, Nicholas D. Huntington   +14 more
doaj   +1 more source

FUT8: AN EMERGING DRIVER OF METASTASIS

Pakistan Journal of Medicine and Dentistry
This critical research periodical is mainly based on critical review of research article titled “A Systems Biology Approach Identifies FUT8 as a Driver of Melanoma Metastasis” published in Cancer Cell by Agrawal et al1. Glycosylation is the distinct cell and microenvironment relatedmechanism establishing glycosidic linkages with major nutrients by the ...
Zil-e-Rubab PJMD, Hussain Shah
openaire   +1 more source