Results 111 to 120 of about 12,303,749 (312)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Current Situation and Future Perspectives of the Romanian Renewable Energy

Energies, 2018
In 2015, Romania was the first country in Europe that achieved EU targets regarding the share of renewables in the generation mix, far ahead of the 2020 deadline. Starting with the energy structure in Romania, the paper: (1) analyses the evolution of the
Ştefan Dragoş Cîrstea, Claudia Steluţa Martiş, Andreea Cîrstea, Anca Constantinescu-Dobra, Melinda Timea Fülöp   +4 more
doaj   +1 more source

Standardized exercise tests in horses : current situation and future perspectives [PDF]

, 2017
The purpose of this literature review is to clarify how exercise capacity can be measured in horses and which standardized exercise tests (SETs) exist. In this review, the measurement of the exercise capacity of horses is discussed and the standardized ...
Boshuizen, Berit, de Bruijn, Marco, De Maré, Lorie, Delesalle, Catherine, Plancke, Lukas   +4 more
core  

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Advancing autonomy through lifelong learning: a survey of autonomous intelligent systems

Frontiers in Neurorobotics
The combination of lifelong learning algorithms with autonomous intelligent systems (AIS) is gaining popularity due to its ability to enhance AIS performance, but the existing summaries in related fields are insufficient.
Dekang Zhu, Qianyi Bu, Zhongpan Zhu, Zhongpan Zhu, Yujie Zhang, Zhipeng Wang   +5 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

From Machine Learning to Patient Outcomes: A Comprehensive Review of AI in Pancreatic Cancer

Diagnostics
Pancreatic cancer is a highly aggressive and difficult-to-detect cancer with a poor prognosis. Late diagnosis is common due to a lack of early symptoms, specific markers, and the challenging location of the pancreas.
Satvik Tripathi, Azadeh Tabari, Arian Mansur, Harika Dabbara, Christopher P. Bridge, Dania Daye   +5 more
doaj   +1 more source

Future perspectives in psychotherapy [PDF]

, 2018
To date, the effectiveness of psychotherapy for the treatment of most mental disorders is empirically well documented. From an "evidence-based medicine” viewpoint, psychotherapy, as compared to other treatments in medicine, can be regarded as one of the ...
Schnyder, Ulrich
core  

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source