Results 121 to 130 of about 12,303,749 (312)

Neoadjuvant Strategies for Triple Negative Breast Cancer: Current Evidence and Future Perspectives

MedComm – Future Medicine
Triple‐negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer, characterized by poor prognosis and limited therapeutic options.
Zhenjun Huang, Qing Peng, Luhui Mao, Wenhao Ouyang, Yunjing Xiong, Yujie Tan, Haizhu Chen, Zebang Zhang, Tang Li, Yuanjia Hu, Ying Wang, Wei Zhang, Herui Yao, Yunfang Yu   +13 more
doaj   +1 more source

Evolutionary patterns and future perspectives of joint replacement in arthritis patients: a comprehensive analysis of findings over the past decades

EFORT Open Reviews
Purpose: This study aimed to comprehensively review the current research status and trends of joint replacement for arthritis patients worldwide. Methods: Literature related to joint replacement for arthritis patients from 2004 to 2024 was extracted from
Sha-Sha Tao, Jian Tang, Yu-Chen Liu, Shu-Zhen Xu, Zhu Chen, Hai-Feng Pan   +5 more
doaj   +1 more source

An Overview of Construction Occupational Accidents in Hong Kong: A Recent Trend and Future Perspectives

Applied Sciences, 2019
The construction industry is infamous for a high number of fatalities around the world. The Hong Kong construction industry is also one of the most hazardous industries for worker’s safety compared to all other industries.
Muhammad Shafique, Muhammad Rafiq
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

The Future of Vertical-Axis Wind Turbines: Opportunities, Challenges, and Sustainability Perspectives

Energies
This Vertical-axis wind turbines (VAWTs) are emerging as promising alternatives to conventional horizontal-axis wind turbines (HAWTs) for renewable energy generation, particularly in urban and offshore environments.
Mladen Bošnjaković, Robert Santa, Jelena Topić Božič, Simon Muhič   +3 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Editorial: New challenges and future perspectives in Alzheimer's disease and related dementias

Frontiers in Aging Neuroscience, 2023
Gong-Ping Liu, Gong-Ping Liu, Shuo Wang
doaj   +1 more source

A super massive black hole binary in 3C66B: future observational perspectives

, 2004
Supermassive black hole binaries (SMBHBs) may exist in the centers of galaxies and active galactic nuclei (AGN) and are expected to be fairly common in the Universe as a consequence of merging processes between galaxies.
A. A. Nucita, Abraham, Begelman, Boller, De Paolis, De Paolis, F. De Paolis, Fitchett, G. Ingrosso, Guainazzi, Hardcastle, Jenet, Kaspi, Kormendy, Leahy, Lehto, Lobanov, Matthews, Miller, Nakano, Ni, Parma, Peters, Pietila, Rees, Richstone, Rieger, Sadun, Schoenmakers, Sillanpää, Spada, Sudou, Urry, Wang, Wu, Yu   +35 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source