Results 241 to 250 of about 601,530 (360)

Extracellular ATP increases agonist potency and reduces latency at class B G protein-coupled receptors. [PDF]

Mol Pharmacol
Zhu S, Yuan A, Duffy T, Kim BH, Ozawa T, Dixon SJ, Chidiac P.   +6 more
europepmc   +1 more source

Lipid-mediated Regulation of G Protein-coupled Receptor Kinases 2 and 3 [PDF]

, 1995
Shubhik DebBurman, Judy Ptasienski, Evan Boetticher, Jon W. Lomasney, Jeffrey Benovic, Marie Thérèse Hosey   +5 more
openalex   +1 more source

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

G proteins of the Gq family couple the H2 histamine receptor to phospholipase C. [PDF]

, 1996
Bernhard Kühn, Andrea Schmid, Christian Harteneck, Thomas Gudermann, G. Schultz   +4 more
openalex   +1 more source

Microglia limit brain tumor development by restricting tumor cell proliferation and inducing T‐cell immunity

Molecular Oncology, EarlyView.
Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun, Ching‐Fang Yu, Sheng‐Yan Wu, Wei‐Chung Cheng, Chi‐Shiun Chiang, Fang‐Hsin Chen   +5 more
wiley   +1 more source

The regulatory functions of G protein-coupled receptors signaling pathways in B cell differentiation and development contributing to autoimmune diseases. [PDF]

Cell Biosci
Shao Y, Mei Y, Tan Y, Yang M, Wu H.
europepmc   +1 more source

The GRK4 Subfamily of G Protein-coupled Receptor Kinases [PDF]

, 1999
Richard T. Premont, Alexander D. Macrae, Samuel Aparício, Humphrey E. Kendall, Jeffrey E. Welch, Robert J. Lefkowitz   +5 more
openalex   +1 more source

A single gene mutation predicts response to immune checkpoint blockade in ovarian clear cell carcinoma

Molecular Oncology, EarlyView.
Loss‐of‐function mutations in the scaffold subunit of protein phosphatase 2A (PP2A), PPP2R1A, sensitize ovarian clear cell carcinoma to immune checkpoint blockade (ICB) by enhancing the interferon gamma response and promoting antitumor immune cell infiltration.
Matheus Henrique Dias, René Bernards
wiley   +1 more source

Emerging modes of regulation of neuromodulatory G protein-coupled receptors. [PDF]

Trends Neurosci
Gonzalez-Hernandez AJ, Munguba H, Levitz J.   +2 more
europepmc   +1 more source

Regulation of the G-Protein-Coupled α-Factor Pheromone Receptor by Phosphorylation [PDF]

, 1996
Qijun Chen, James B. Konopka
openalex   +1 more source