Results 51 to 60 of about 15,824,629 (262)

Survival After Hematopoietic Stem Cell Transplantation in Diamond–Blackfan Anemia Syndrome: The Role of Iron Overload—A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We assessed the effect of iron overload (IO) on mortality and complications following hematopoietic stem cell transplantation (HSCT) in patients with Diamond–Blackfan anemia syndrome (DBAS) in a systematic review of individual participant data and cohort data from observational studies.
Geoffrey Z. L. Kuppens, Evangelia Kiakou, Lieke de Zwart, Maurizio Miano, Eduard J. van Beers, Marc Bierings, Marije Bartels   +6 more
wiley   +1 more source

Fever-like temperature modification differentially affects in vitro signaling of bradykinin B-1 and B-2 receptors [PDF]

, 2011
The bradykinin (BK) B-2 and B-1 receptors (B2R, B1R) belong to the rhodopsin-like G protein-coupled receptors (GPCRs) and are involved in (patho)physiological processes such as blood pressure regulation or inflammation.
Dinkel, Klaus, Faussner, Alexander, Marianne Jochum, Jasmin Leschner, Alexander Faussner, Jochum, Marianne, Leschner, Jasmin, Larisa Ring, Ring, Larisa, Jens Feierler, Feierler, Jens, Klaus Dinkel   +11 more
core   +1 more source

Plasma membrane preassociation drives β-arrestin coupling to receptors and activation [PDF]

, 2023
β-arrestin plays a key role in G protein-coupled receptor (GPCR) signaling and desensitization. Despite recent structural advances, the mechanisms that govern receptor-β-arrestin interactions at the plasma membrane of living cells remain elusive.
O’Brien, Shannon L., Stepniewski, Tomasz M, Hill, Stephen J., Maria Makarova, Hoffmann, Carsten, Mistry, Ravi, Shannon L. O’Brien, Davide Calebiro, Stephen J. Hill, Carsten Hoffmann, Julia Drube, Jana Selent, Baidya, Mithu, Calebiro, Davide, Mithu Baidya, Lanoiselée, Yann, Medel-Lacruz, Brian, Owen, Dylan M., Owen, Dylan M, Stepniewski, Tomasz M., Tamara Miljus, Dylan M. Owen, Miljus, Tamara, Goulding, Joëlle, Stepniewski, Tomasz Maciej, 1988-, Grimes, Jak, Hill, Stephen J, Drube, Julia, Jak Grimes, Ravi Mistry, Medel Lacruz, Brian, Koszegi, Zsombor; id_orcid, Zsombor Koszegi, Arun K. Shukla, Koszegi, Zsombor, Makarova, Maria, Yann Lanoiselée, Selent, Jana, Brian Medel-Lacruz, O'Brien, Shannon L., Tomasz M. Stepniewski, O'Brien, Shannon L; id_orcid, Shukla, Arun K., Shukla, Arun K, Joëlle Goulding   +44 more
core   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Frizzled Proteins are bona fide G Protein-Coupled Receptors [PDF]

, 2009
Receptors of the Frizzled family initiate Wnt ligand-dependent signaling controlling multiple steps in organism development and highly conserved in evolution. Misactivation of the Wnt/Frizzled signaling is cancerogenic.
Silke Buestorf, Vladimir L. Katanaev
core  

An artificial immune system for clustering amino acids in the context of protein function classification [PDF]

, 2009
This paper addresses the classification task of data mining (a form of supervised learning) in the context of an important bioinformatics problem, namely the prediction of protein functions.
Timmis, Jon, Clark, Edward, Flower, Darren R., Secker, Andrew D., Davies, Matthew N., Freitas, Alex A.   +5 more
core   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Inferring the lifetime of endosomal protein complexes by fluorescence recovery after photobleaching [PDF]

, 2008
Cellular signal transduction is dynamic, with signaling proteins continually associating and dissociating into and from protein complexes. Here we present a fluorescence recovery after photobleaching technique to determine the lifetime of protein ...
Gousseva, Veronika, Laporte, Stéphane A., Swain, Peter S, Swain, Peter S., Simaan, May, Laporte, Stéphane A   +5 more
core   +1 more source

G-Protein Coupled Receptors Targeted by Analgesic Venom Peptides

Toxins, 2017
Chronic pain is a complex and debilitating condition associated with a large personal and socioeconomic burden. Current pharmacological approaches to treating chronic pain such as opioids, antidepressants and anticonvulsants exhibit limited efficacy in ...
James T. Daniel, Richard J. Clark
doaj   +1 more source