Results 81 to 90 of about 393,484 (315)

The mutational landscape of human olfactory G protein-coupled receptors

BMC Biology, 2021
Background Olfactory receptors (ORs) constitute a large family of sensory proteins that enable us to recognize a wide range of chemical volatiles in the environment.
Ramón Cierco Jimenez, Nil Casajuana-Martin, Adrián García-Recio, Lidia Alcántara, Leonardo Pardo, Mercedes Campillo, Angel Gonzalez   +6 more
doaj   +1 more source

Plasma membrane preassociation drives β-arrestin coupling to receptors and activation

, 2023
β-arrestin plays a key role in G protein-coupled receptor (GPCR) signaling and desensitization. Despite recent structural advances, the mechanisms that govern receptor-β-arrestin interactions at the plasma membrane of living cells remain elusive.
O’Brien, Shannon L., Stepniewski, Tomasz M, Hill, Stephen J., Maria Makarova, Hoffmann, Carsten, Mistry, Ravi, Shannon L. O’Brien, Davide Calebiro, Stephen J. Hill, Carsten Hoffmann, Julia Drube, Jana Selent, Baidya, Mithu, Calebiro, Davide, Mithu Baidya, Lanoiselée, Yann, Medel-Lacruz, Brian, Owen, Dylan M., Owen, Dylan M, Stepniewski, Tomasz M., Tamara Miljus, Dylan M. Owen, Miljus, Tamara, Goulding, Joëlle, Stepniewski, Tomasz Maciej, 1988-, Grimes, Jak, Hill, Stephen J, Drube, Julia, Jak Grimes, Ravi Mistry, Medel Lacruz, Brian, Koszegi, Zsombor; id_orcid, Zsombor Koszegi, Arun K. Shukla, Koszegi, Zsombor, Makarova, Maria, Yann Lanoiselée, Selent, Jana, Brian Medel-Lacruz, O'Brien, Shannon L., Tomasz M. Stepniewski, O'Brien, Shannon L; id_orcid, Shukla, Arun K., Shukla, Arun K, Joëlle Goulding   +44 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

G-protein-coupled receptor kinases

Trends in Biochemical Sciences, 1991
Rhodopsin kinase and the beta-adrenergic receptor kinase (beta ARK) catalyse the phosphorylation of the activated forms of the G-protein-coupled receptors, rhodopsin and the beta 2-adrenergic receptor (beta 2AR), respectively. The interaction between receptor and kinase is independent of second messengers and appears to involve a multipoint attachment ...
Palczewskl, Krzvsztof, Benovic, Jeffrey L   +1 more
openaire   +4 more sources

RINGdb: An integrated database for G protein-coupled receptors and regulators of G protein signaling

BMC Genomics, 2006
Background Many marketed therapeutic agents have been developed to modulate the function of G protein-coupled receptors (GPCRs). The regulators of G-protein signaling (RGS proteins) are also being examined as potential drug targets.
Huang Hsien-Da, Wu Li-Cheng, Sun Wei-Hsin, Fang Yu-Ching, Juan Hsueh-Fen, Horng Jorng-Tzong   +5 more
doaj   +1 more source

Hierarchical classification of G-protein-coupled receptors with a PSO/ACO algorithm [PDF]

, 2006
In our previous work we have proposed a hybrid Particle Swarm Optimisation / Ant Colony Optimisation (PSO/ACO) algorithm for discovering classification rules.
Holden, Nicholas, Freitas, Alex A.
core  

Adhesion GPCRs are widely expressed throughout the subsections of the gastrointestinal tract [PDF]

, 2012
Background: G protein-coupled receptors (GPCRs) represent one of the largest families of transmembrane receptors and the most common drug target. The Adhesion subfamily is the second largest one of GPCRs and its several members are known to mediate ...
Schiöth, Helgi B,, Olszewski, Pawel K, Cedernaes, Jonathan,, Vergoni, Anna V, Schiöth, Helgi B, Jonathan Cedernaes, Schiöth, Helgi B., Anna V Vergoni, Pawel K Olszewski, Badiali, Luca, Luca Badiali, Olof Nylander, Badiali, Luca,, Helgi B Schiöth, Nylander, Olof, Nylander, Olof,, VERGONI, Anna Valeria, Olszewski, Pawel K., Vergoni, Anna V., Cedernaes, Jonathan, Olszewski, Pawel K,   +20 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Using green fluorescent protein to understand the mechanisms of G-protein-coupled receptor regulation

Brazilian Journal of Medical and Biological Research, 1998
G protein-coupled receptor (GPCR) activation is followed rapidly by adaptive changes that serve to diminish the responsiveness of a cell to further stimulation.
S.S.G. Ferguson
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source