Results 251 to 260 of about 32,953 (312)

Impact of G-quadruplex RNA oxidation on its conformational dynamics and interaction with ALS-associated TDP-43. [PDF]

Sci Rep
Ishiguro A.
europepmc   +1 more source

Scalable Platform Enabling Reservoir Computing With Nanoporous Oxide Memristors for Image Recognition and Time Series Prediction

Advanced Intelligent Systems, EarlyView.
The approach of physical in materia computing incorporates parallel computing within the medium itself. A scalable and energy‐efficient, oxide‐based computational platform is realized in form of a nanoporous network of volatile niobium oxide memristors sandwiched between top and bottom metallic electrodes, and then tested for prediction and ...
Joshua Donald, Ben A. Johnson, Amir Mehrnejat, Alex Gabbitas, Arthur G. T. Coveney, Alexander G. Balanov, Sergey Savel’ev, Pavel Borisov   +7 more
wiley   +1 more source

G-quadruplex structural motifs modulate protein-RNA interactions within the transcriptome. [PDF]

Genome Biol
Bhatt U, Evans CW, Cucchiarini A, Gros J, Iyer KS, Mergny JL, Smith NM.   +6 more
europepmc   +1 more source

Integrating Artificial Intelligence With Droplet‐Based Microfluidics: Advances, Challenges, and Emerging Opportunities

Advanced Intelligent Systems, EarlyView.
Droplet‐based microfluidics enables precise, high‐throughput microscale reactions but continues to face challenges in scalability, reproducibility, and data complexity. This review examines how artificial intelligence enhances droplet generation, detection, sorting, and adaptive control and discusses emerging opportunities for clinical and industrial ...
Junyan Lai, Sukrit Gaira, Rongfeng Wang, Qingtian Zhang, Ming Li, Liao Wu, Diangeng Li, Yi Li, Chengchen Zhang, Jinhong Guo, Shi‐Yang Tang   +10 more
wiley   +1 more source

BMI1 represses G-quadruplex DNA formation to maintain genomic stability during replication. [PDF]

J Biol Chem
Hanna R, Deneault E, Bernier G.
europepmc   +1 more source

Natural Aging of Biomaterials in Ambient and Physiological Environments

Advanced NanoBiomed Research, EarlyView.
Biomaterials used in biomedical applications can change their physical properties over time, even under ambient and physiological conditions. This review highlights key studies on the natural aging of materials ranging from soft hydrogels to metals and ceramics, emphasizing how time‐dependent changes influence function and performance.
Shuyu Zhang, Anne E. Staples
wiley   +1 more source

Destabilizing Interactions in Human Telomeric G-Quadruplex Multimers. [PDF]

J Phys Chem Lett
Bertini L, Trapella M, Mostarac D, Libera V, Petrillo C, De Michele C, Comez L, Paciaroni A.   +7 more
europepmc   +1 more source

NUAK2 Inhibition Enhances Macromolecular Drug Delivery in a 3D Fibrotic Model of the Pancreatic Tumor Microenvironment

Advanced NanoBiomed Research, EarlyView.
Using a 3D cell culture model of the fibrotic barrier in pancreatic cancer, this work shows that inhibiting NUAK2 kinase in pancreatic stellate cells enhances macromolecular drug delivery. Mechanistically, NUAK2 inhibition disrupted actin stress fiber assembly to downregulate collagen I expression, thus enhancing macromolecular permeability.
Misaki Nakamura, Hiroyoshi Y. Tanaka, Mayu Ohira, Haruko Ohta‐Okano, Reika Nakamura, Yu Seno, Saaya Yara, Sakura Fujita, Daichi Shibata, Masaya Yamamoto, Shinichi Toyooka, Kensuke Osada, Horacio Cabral, Atsushi Masamune, Mitsunobu R. Kano   +14 more
wiley   +1 more source

Functional and Structural Analyses of Diverse G-Quadruplex and Non-G-Quadruplex Structures Formed by Guanine-Rich Nucleic Acids: A Study on the Insulin Aptamer. [PDF]

Small
Iwano N, Oyama T, Tomizawa M, Inaba S, Mori R, Nakazawa Y, Sode K, Tsukakoshi K, Nakano T, Ikebukuro K.   +9 more
europepmc   +1 more source

Minimal ATP‐Independent N2‐Reducing Systems Defined by L‐Cluster‐Bound Nitrogenase Assembly Platforms

Angewandte Chemie, EarlyView.
Association of the L‐cluster with the nitrogenase assembly proteins NifEN (NifENL) or NifB (NifBL) intrinsically endows these proteins with N2‐reducing activity, enabling in vitro N2‐reduction by NifENL and NifBL when supplied with chemical reductants or photoexcited quantum dots while supporting in vivo N2‐fixation in NifENL‐ and NifENL‐expressing ...
Robert Quechol, Yimo Yang, Chi Chung Lee, Markus W. Ribbe, Yilin Hu   +4 more
wiley   +1 more source