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NMR spectroscopy of G-quadruplexes
Methods, 2012G-rich DNA and RNA sequences can form four-stranded structures called G-quadruplexes. Such structures have gained significant interest in the past decade with increasing evidence of their biological role. G-quadruplex structures can be polymorphic and dynamic. NMR spectroscopy has played an important role in G-quadruplex research. Here we review on the
Michael, Adrian +2 more
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Thermodynamics of G-quadruplexes
2012In 1910 Ivar Bang reported that concentrated solutions of guanylic acid formed a gel. It took half a century before Gellert et al. in 1962 discovered the structural motif, a guanine-quartet, to be the basis for guanylic acid gelation. This chapter starts with a historical overview and gives credit to Ivar Bang and several other pioneers in the field ...
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Human Papillomavirus G-Quadruplexes
Biochemistry, 2013Infection with human papillomaviruses (HPVs) is one of the most common sexually transmitted infections and can lead to development of head and neck, skin, and anogenital cancer, including cervical cancer, which represents one of the world's most significant health problems.
Katarína Tluková +6 more
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ACS Applied Materials and Interfaces, 2020
A novel electrochemical hydrogen peroxide (H2O2) sensor based on Cu-porphyrin(Cu-TCPP)/G-quadruplex-hemin nanocomposite was constructed by assembling two-dimensional Cu-TCPP metal organic framework nanofilm and G-quadruplex-hemin DNAzyme.
Junping Ma +3 more
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A novel electrochemical hydrogen peroxide (H2O2) sensor based on Cu-porphyrin(Cu-TCPP)/G-quadruplex-hemin nanocomposite was constructed by assembling two-dimensional Cu-TCPP metal organic framework nanofilm and G-quadruplex-hemin DNAzyme.
Junping Ma +3 more
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WIREs RNA, 2012
AbstractG‐quadruplexes are noncanonical structures formed by G‐rich DNA and RNA sequences that fold into a four‐stranded conformation. Experimental studies and computational predictions show that RNA G‐quadruplexes are present in transcripts associated with telomeres, in noncoding sequences of primary transcripts and within mature transcripts.
Stefania, Millevoi +2 more
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AbstractG‐quadruplexes are noncanonical structures formed by G‐rich DNA and RNA sequences that fold into a four‐stranded conformation. Experimental studies and computational predictions show that RNA G‐quadruplexes are present in transcripts associated with telomeres, in noncoding sequences of primary transcripts and within mature transcripts.
Stefania, Millevoi +2 more
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Transposable elements and G-quadruplexes
Chromosome Research, 2015A significant part of eukaryotic genomes is formed by transposable elements (TEs) containing not only genes but also regulatory sequences. Some of the regulatory sequences located within TEs can form secondary structures like hairpins or three-stranded (triplex DNA) and four-stranded (quadruplex DNA) conformations.
Eduard, Kejnovsky +2 more
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G-quadruplex DNA for construction of biosensors
, 2020DNA-based biosensors have been widely used for its stable chemical properties, cost-effectiveness, and easy modification. G-quadruplex (G4) DNA has attracted growing interest since it can be used for both target recognition and signal transduction.
Hualin Yang, Yu Zhou, Juewen Liu
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G-quadruplexes as therapeutic targets
Biopolymers, 2000The ends of chromosomes (telomeres) consist of tandem repeats of guanine-rich sequences. In eukaryotics, telomeric DNA is single stranded for the final few hundred bases. These single-stranded sequences can fold into a variety of four-stranded structures (quadruplexes) held together by quartets of hydrogen-bonded guanine bases.
S, Neidle, M A, Read
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Modulation of histone modifications and G-quadruplex structures by G-quadruplex-binding proteins
Biochemical and Biophysical Research Communications, 2020The functions of local conformations of non-B form DNA and RNA, such as the G-quadruplex, are thought to be regulated by their specific binding proteins. They regulate the formation of G-quadruplexes in cells and affect the biological functions of G-quadruplexes.
Takanori, Oyoshi, Tatsuki, Masuzawa
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Content Detection of G-Quadruplex DNA in Live Cells Based on Photon Counts and Complex Structures.
Angewandte Chemie, 2020G-quadruplex DNA undergoes structural polymorphism, leading challenging around using selectively recognizing probe to accurately detect G-quadruplexes in vivo .
Liu‐Yi Liu +6 more
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