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RNA G-Quadruplexes: G-quadruplexes with “U” Turns
Current Pharmaceutical Design, 2012G-quadruplexes are non canonical secondary structures held together by Hoogsteen bonded planar guanine quartets formed in G-rich sequences in DNA and RNA. Considerable research over the past three decades has contributed to a great deal of understanding of these unusual structures in DNA.
Tani, Agarwal +4 more
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Bulges in G-Quadruplexes: Broadening the Definition of G-Quadruplex-Forming Sequences
Journal of the American Chemical Society, 2013We report on the first solution structure of an intramolecular G-quadruplex containing a single bulge and present evidence for extensive occurrence of bulges in different G-quadruplex contexts. The NMR solution structure of the d(TTGTGGTGGGTGGGTGGGT) sequence reveals a propeller-type parallel-stranded G-quadruplex containing three G-tetrad layers ...
Anh Tuan Phan
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Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2017
G-quadruplexes (GQs) are four-stranded nucleic acid secondary structures formed by guanosine (G)-rich DNA and RNA sequences. It is becoming increasingly clear that cellular processes including gene expression and mRNA translation are regulated by GQs. GQ structures have been extensively characterized, however little attention to date has been paid to ...
Robert W, Harkness +1 more
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G-quadruplexes (GQs) are four-stranded nucleic acid secondary structures formed by guanosine (G)-rich DNA and RNA sequences. It is becoming increasingly clear that cellular processes including gene expression and mRNA translation are regulated by GQs. GQ structures have been extensively characterized, however little attention to date has been paid to ...
Robert W, Harkness +1 more
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Luminescent G-quadruplex Probes
Current Pharmaceutical Design, 2012G-quadruplexes have found increasing potential in applications such as molecular therapeutics, diagnostics, and sensing. As a consequence, small molecules capable of selectively detecting G-quadruplexes have received significant attention in recent literature.
Yang, H +4 more
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Macrocyclic G-Quadruplex Ligands
Current Medicinal Chemistry, 2010G-quadruplex stabilizing compounds have recently received increased interest due to their potential application as anticancer therapeutics. A significant number of structurally diverse G-quadruplex ligands have been developed. Some of the most potent and selective ligands currently known are macrocyclic structures which have been modeled after the ...
Nielsen, M C, Ulven, Trond
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Biochimie, 2008
Whilst DNA spends much of its time in the double-stranded form, frequently in storage, wrapped around histones and packaged as chromatin, it can also form other complex structures, which may play a role in natural regulation and gene control. These alternative structures therefore also present an interesting novel series of targets for artificial ...
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Whilst DNA spends much of its time in the double-stranded form, frequently in storage, wrapped around histones and packaged as chromatin, it can also form other complex structures, which may play a role in natural regulation and gene control. These alternative structures therefore also present an interesting novel series of targets for artificial ...
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Current Protocols in Nucleic Acid Chemistry, 2009
AbstractAbsorbance versus temperature curves can provide information on the thermal stability of DNA or RNA quadruplexes. Quadruplex denaturation or renaturation can be followed by recording absorbance at 295 nm rather than 260 nm, the wavelength used to monitor duplex denaturation. This unit describes the use of absorbance versus temperature curves to
Jean-Louis, Mergny, Laurent, Lacroix
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AbstractAbsorbance versus temperature curves can provide information on the thermal stability of DNA or RNA quadruplexes. Quadruplex denaturation or renaturation can be followed by recording absorbance at 295 nm rather than 260 nm, the wavelength used to monitor duplex denaturation. This unit describes the use of absorbance versus temperature curves to
Jean-Louis, Mergny, Laurent, Lacroix
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Human Papillomavirus G-Quadruplexes
Biochemistry, 2013Infection with human papillomaviruses (HPVs) is one of the most common sexually transmitted infections and can lead to development of head and neck, skin, and anogenital cancer, including cervical cancer, which represents one of the world's most significant health problems.
Katarína Tluková +6 more
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WIREs RNA, 2012
AbstractG‐quadruplexes are noncanonical structures formed by G‐rich DNA and RNA sequences that fold into a four‐stranded conformation. Experimental studies and computational predictions show that RNA G‐quadruplexes are present in transcripts associated with telomeres, in noncoding sequences of primary transcripts and within mature transcripts.
Stefania, Millevoi +2 more
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AbstractG‐quadruplexes are noncanonical structures formed by G‐rich DNA and RNA sequences that fold into a four‐stranded conformation. Experimental studies and computational predictions show that RNA G‐quadruplexes are present in transcripts associated with telomeres, in noncoding sequences of primary transcripts and within mature transcripts.
Stefania, Millevoi +2 more
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Organic & Biomolecular Chemistry, 2015
The RNA secondary structure G-quadruplex with its malleable nature can execute diverse biological functions and can be manipulated and used for various applications.
Prachi, Agarwala +2 more
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The RNA secondary structure G-quadruplex with its malleable nature can execute diverse biological functions and can be manipulated and used for various applications.
Prachi, Agarwala +2 more
openaire +2 more sources