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Thermodynamics of G-quadruplexes
2012In 1910 Ivar Bang reported that concentrated solutions of guanylic acid formed a gel. It took half a century before Gellert et al. in 1962 discovered the structural motif, a guanine-quartet, to be the basis for guanylic acid gelation. This chapter starts with a historical overview and gives credit to Ivar Bang and several other pioneers in the field ...
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NMR spectroscopy of G-quadruplexes
Methods, 2012G-rich DNA and RNA sequences can form four-stranded structures called G-quadruplexes. Such structures have gained significant interest in the past decade with increasing evidence of their biological role. G-quadruplex structures can be polymorphic and dynamic. NMR spectroscopy has played an important role in G-quadruplex research. Here we review on the
Michael, Adrian +2 more
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Transposable elements and G-quadruplexes
Chromosome Research, 2015A significant part of eukaryotic genomes is formed by transposable elements (TEs) containing not only genes but also regulatory sequences. Some of the regulatory sequences located within TEs can form secondary structures like hairpins or three-stranded (triplex DNA) and four-stranded (quadruplex DNA) conformations.
Eduard, Kejnovsky +2 more
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G-quadruplexes as therapeutic targets
Biopolymers, 2000The ends of chromosomes (telomeres) consist of tandem repeats of guanine-rich sequences. In eukaryotics, telomeric DNA is single stranded for the final few hundred bases. These single-stranded sequences can fold into a variety of four-stranded structures (quadruplexes) held together by quartets of hydrogen-bonded guanine bases.
S, Neidle, M A, Read
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Modulation of histone modifications and G-quadruplex structures by G-quadruplex-binding proteins
Biochemical and Biophysical Research Communications, 2020The functions of local conformations of non-B form DNA and RNA, such as the G-quadruplex, are thought to be regulated by their specific binding proteins. They regulate the formation of G-quadruplexes in cells and affect the biological functions of G-quadruplexes.
Takanori, Oyoshi, Tatsuki, Masuzawa
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Nonaqueous G-Quadruplex Ionogels
LangmuirSupramolecular ionogels, as an emerging class of materials, utilize the intriguing properties of ionic liquids (ILs) and offer a promising method for constructing functional materials in anhydrous solvents. G-Quadruplex, assembled from guanine-rich nucleic acid building blocks, is an important structure closely associated with life and leads to the ...
Zeyi Wang +4 more
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2011
Metal ions stabilize quadruplex nucleic acids by coordinating the O6 guanine atoms from G-quartets. These quartets form the basic motif of quadruplex structures. This article systematically surveys the available crystallographic data on native quadruplexes, their ligand complexes and (in one instance) a protein complex.
Nancy H, Campbell, Stephen, Neidle
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Metal ions stabilize quadruplex nucleic acids by coordinating the O6 guanine atoms from G-quartets. These quartets form the basic motif of quadruplex structures. This article systematically surveys the available crystallographic data on native quadruplexes, their ligand complexes and (in one instance) a protein complex.
Nancy H, Campbell, Stephen, Neidle
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Unlocking G-quadruplex: Effect of unlocked nucleic acid on G-quadruplex stability
Biochimie, 2011G-quadruplexes are common structural motifs in aptamers. UNA or unlocked nucleic acid is the latest nucleic acid modification. We have attempted to evaluate the impact of UNA modification on the structure and stability of G-quadruplex oligonucleotides for application in aptamer design.
Tani, Agarwal +2 more
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A Topological Classification of G-Quadruplex Structures
Nucleosides, Nucleotides & Nucleic Acids, 2007A topological classification of most quadruplex structures is proposed, based on two main characteristics: 1) the relative orientation of the strands and 2) the nature of the loops connecting the strands.
ESPOSITO, VERONICA +5 more
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A hitchhiker's guide to G-quadruplex ligands
Org. Biomol. Chem., 2008Over the past decade, nucleic acid chemists have seen the spectacular emergence of molecules designed to interact efficiently and selectively with a peculiar DNA structure named G-quadruplex. Initially derived from classical DNA intercalators, these G-quadruplex ligands progressively became the focal point of new excitement since they appear to inhibit
Monchaud, David +1 more
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