Results 281 to 290 of about 13,927,214 (311)

G-Quadruplexes and Metal Ions

2011
Metal ions stabilize quadruplex nucleic acids by coordinating the O6 guanine atoms from G-quartets. These quartets form the basic motif of quadruplex structures. This article systematically surveys the available crystallographic data on native quadruplexes, their ligand complexes and (in one instance) a protein complex.
Nancy H, Campbell, Stephen, Neidle
openaire   +2 more sources

Unlocking G-quadruplex: Effect of unlocked nucleic acid on G-quadruplex stability

Biochimie, 2011
G-quadruplexes are common structural motifs in aptamers. UNA or unlocked nucleic acid is the latest nucleic acid modification. We have attempted to evaluate the impact of UNA modification on the structure and stability of G-quadruplex oligonucleotides for application in aptamer design.
Tani, Agarwal, Santosh, Kumar, Souvik, Maiti   +2 more
openaire   +2 more sources

A Topological Classification of G-Quadruplex Structures

Nucleosides, Nucleotides & Nucleic Acids, 2007
A topological classification of most quadruplex structures is proposed, based on two main characteristics: 1) the relative orientation of the strands and 2) the nature of the loops connecting the strands.
ESPOSITO, VERONICA, GALEONE, ALDO, MAYOL, LUCIANO, OLIVIERO, GIORGIA, RANDAZZO, LOREDANA, VIRGILIO, ANTONELLA   +5 more
openaire   +3 more sources

G-quadruplex DNAzyme as peroxidase mimetic in a colorimetric biosensor for ultrasensitive and selective detection of trace tetracyclines in foods.

Food Chemistry, 2021
Yue Tang, Xiaohuan Huang, Xueli Wang, Chunxiao Wang, Han Tao, Yuangen Wu   +5 more
semanticscholar   +1 more source

A hitchhiker's guide to G-quadruplex ligands

Org. Biomol. Chem., 2008
Over the past decade, nucleic acid chemists have seen the spectacular emergence of molecules designed to interact efficiently and selectively with a peculiar DNA structure named G-quadruplex. Initially derived from classical DNA intercalators, these G-quadruplex ligands progressively became the focal point of new excitement since they appear to inhibit
Monchaud, David, Teulade-Fichou, Marie-Paule   +1 more
openaire   +3 more sources

Selective discrimination and classification of G-quadruplex structures with a host–guest sensing array

Nature Chemistry, 2021
Junyi Chen, Briana L Hickey, Linlin Wang, Jiwon Lee, Adam D. Gill, Alessia Favero, R. Pinalli, E. Dalcanale, R. Hooley, Wenwan Zhong   +9 more
semanticscholar   +1 more source

Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription

Proceedings of the National Academy of Sciences of the United States of America, 2002
Adam Siddiqui-Jain, C. Grand, D. Bearss, L. Hurley   +3 more
semanticscholar   +1 more source

G-quadruplex structures mark human regulatory chromatin

Nature Genetics, 2016
Robert Hänsel-Hertsch, D. Beraldi, Stefanie V. Lensing, Giovanni Marsico, Katherine G. Zyner, Aled J. Parry, M. Di Antonio, J. Pike, H. Kimura, M. Narita, D. Tannahill, S. Balasubramanian   +11 more
semanticscholar   +1 more source

High-throughput sequencing of DNA G-quadruplex structures in the human genome

Nature Biotechnology, 2015
V. S. Chambers, Giovanni Marsico, J. M. Boutell, M. Di Antonio, G. P. Smith, S. Balasubramanian   +5 more
semanticscholar   +1 more source

Reversible Photoswitching of a G‐Quadruplex

Angewandte Chemie, 2009
Shinzi, Ogasawara, Mizuo, Maeda
openaire   +2 more sources