Results 261 to 270 of about 13,927,214 (311)

Luminescent G-quadruplex Probes

Current Pharmaceutical Design, 2012
G-quadruplexes have found increasing potential in applications such as molecular therapeutics, diagnostics, and sensing. As a consequence, small molecules capable of selectively detecting G-quadruplexes have received significant attention in recent literature.
Yang, H, Chan, DSH, Ma, DL, Leung, CH, He, HZ   +4 more
openaire   +4 more sources

Macrocyclic G-Quadruplex Ligands

Current Medicinal Chemistry, 2010
G-quadruplex stabilizing compounds have recently received increased interest due to their potential application as anticancer therapeutics. A significant number of structurally diverse G-quadruplex ligands have been developed. Some of the most potent and selective ligands currently known are macrocyclic structures which have been modeled after the ...
Nielsen, M C, Ulven, Trond
openaire   +3 more sources

G-Quadruplex-Induced Liquid-Liquid Phase Separation in Biomimetic Protocells.

Journal of the American Chemical Society, 2021
Biomolecular condensates comprised of specific proteins and nucleic acids are now recognized as one of the key organizing mechanisms in eukaryotic cells.
Xuejiao Liu, Yansong Xiong, Chunjuan Zhang, Rongji Lai, Hui Liu, Ruizi Peng, Ting Fu, Qiaoling Liu, X. Fang, S. Mann, W. Tan   +10 more
semanticscholar   +1 more source

G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies.

Trends in Molecular Medicine, 2020
The clinical applicability of G-quadruplexes (G4s) as anticancer drugs is currently being evaluated. Several G4 ligands and aptamers are undergoing clinical trials following the notable examples of quarfloxin and AS1411, respectively.
Josué Carvalho, J. Mergny, G. Salgado, J. Queiroz, C. Cruz   +4 more
semanticscholar   +1 more source

A Sensitive Aptasensor Based on a Hemin/G-Quadruplex-Assisted Signal Amplification Strategy for Electrochemical Detection of Gastric Cancer Exosomes.

Small, 2019
Emerging evidence indicates that exosomes derived from gastric cancer cells enhance tumor migration and invasion through the modulation of the tumor microenvironment. However, it remains a major problem to detect cancer-specific exosomes due to technical
Rongrong Huang, Lei He, Yanyan Xia, Hongpan Xu, Chang Liu, Hui Xie, Su Wang, Lijun Peng, Yufeng Liu, Yuan Liu, N. He, Zhiyang Li   +11 more
semanticscholar   +1 more source

Bulges in G-Quadruplexes: Broadening the Definition of G-Quadruplex-Forming Sequences

Journal of the American Chemical Society, 2013
We report on the first solution structure of an intramolecular G-quadruplex containing a single bulge and present evidence for extensive occurrence of bulges in different G-quadruplex contexts. The NMR solution structure of the d(TTGTGGTGGGTGGGTGGGT) sequence reveals a propeller-type parallel-stranded G-quadruplex containing three G-tetrad layers ...
Vineeth Thachappilly, Mukundan, Anh Tuân, Phan   +1 more
openaire   +2 more sources

Hunting G-quadruplexes

Biochimie, 2008
Whilst DNA spends much of its time in the double-stranded form, frequently in storage, wrapped around histones and packaged as chromatin, it can also form other complex structures, which may play a role in natural regulation and gene control. These alternative structures therefore also present an interesting novel series of targets for artificial ...
openaire   +2 more sources

UV Melting of G‐Quadruplexes

Current Protocols in Nucleic Acid Chemistry, 2009
AbstractAbsorbance versus temperature curves can provide information on the thermal stability of DNA or RNA quadruplexes. Quadruplex denaturation or renaturation can be followed by recording absorbance at 295 nm rather than 260 nm, the wavelength used to monitor duplex denaturation. This unit describes the use of absorbance versus temperature curves to
Jean-Louis, Mergny, Laurent, Lacroix
openaire   +2 more sources

Human Papillomavirus G-Quadruplexes

Biochemistry, 2013
Infection with human papillomaviruses (HPVs) is one of the most common sexually transmitted infections and can lead to development of head and neck, skin, and anogenital cancer, including cervical cancer, which represents one of the world's most significant health problems.
Katarína Tluková, Maja Maruai, Petra Tóthová, Lubos Bauer, Primo~ `ket, Janez Plavec, Viktor Viglasky   +6 more
openaire   +2 more sources

Amplified Electrochemical Hydrogen Peroxide Sensing Based on Cu-porphyrin Metal Organic Framework Nanofilm and G-quadruplex-hemin DNAzyme.

ACS Applied Materials and Interfaces, 2020
A novel electrochemical hydrogen peroxide (H2O2) sensor based on Cu-porphyrin(Cu-TCPP)/G-quadruplex-hemin nanocomposite was constructed by assembling two-dimensional Cu-TCPP metal organic framework nanofilm and G-quadruplex-hemin DNAzyme.
Junping Ma, Guozhen Chen, Wushuang Bai, Jianbin Zheng   +3 more
semanticscholar   +1 more source