Results 11 to 20 of about 50,331 (195)

Chemical Synthesis of Pseudomonas aeruginosa, Staphylococcus aureus, and Acinetobacter baumannii Capsular Polysaccharide Fragments as Leads for Cross-Protection. [PDF]

Angew Chem Int Ed Engl
A total of 16 chemically synthesized capsular polysaccharide (CPS) fragments related to Pseudomonas aeruginosa, Staphylococcus aureus, and Acinetobacter baumannii were analyzed by glycan microarray. Comparative screening revealed three conserved epitopes that act as cross‐protective vaccine lead candidates against multidrug‐resistant (MDR) bacterial ...
Mishra AK, Reuber EE, Rai D, Sander LE, Duerr J, Graeber SY, Mall MA, Fries BC, Seeberger PH, Kulkarni SS.   +9 more
europepmc   +3 more sources

Serum-Based KRASG12/G13 Mutation Detection Using Droplet Digital PCR: Clinical Implications and Limitations in Colorectal Adenocarcinoma With Tumor Heterogeneity

Frontiers in Oncology, 2021
BackgroundCell-free DNA (cfDNA) has arisen as an alternative target for evaluating somatic mutations in cancer. KRAS mutation status is critical for targeted therapy in colorectal adenocarcinoma (CRAC).
Ju Seok Kim, Go Eun Bae, Seok-Hwan Kim, Min Kyung Choi, Min-Kyung Yeo   +4 more
doaj   +1 more source

Identification and Characterization of a Potential Probiotic, Clostridium butyricum G13, Isolated from the Intestine of the Mud Crab (Scylla paramamosain)

Microbiology Spectrum, 2023
The butyrate-producing bacterium Clostridium butyricum has been proven to be important in improving the growth and health benefits of aquatic animals. In this study, C.
Huifen Liang, Ngoc Tuan Tran, Taoqiu Deng, Jinkun Li, Yifan Lei, Mohammad Akibul Hasan Bakky, Ming Zhang, Rui Li, Wenxuan Chen, Yueling Zhang, Xiuli Chen, Shengkang Li   +11 more
doaj   +1 more source

G13-dependent Activation of MAPK by Thyrotropin [PDF]

Journal of Biological Chemistry, 2008
Stimulation of the thyrotropin receptor (TSHR) activates G proteins of all four subfamilies (G(s), G(i/o), G(q/11), and G(12/13)). Whereas G(s)/cAMP-dependent cellular responses upon TSHR stimulation are well established, other signaling pathways are less characterized.
Büch, Thomas R. H., Biebermann, Heike, Kalwa, Hermann, Pinkenburg, Olaf, Hager, Denise, Barth, Holger, Aktories, Klaus, Breit, Andreas, Gudermann, Thomas   +8 more
openaire   +3 more sources

Helping to keep History relevant: Multimedia and authentic learning

Journal of Interactive Media in Education, 2009
The subject based curriculum attracts lively debate in many countries being accused of fragmenting teaching and learning, erecting artificial barriers and failing to teach the skills required in the twenty first century (Hazlewood 2005). Cross-curricular
Peter Hillis, Drew Calderhead
doaj   +1 more source

Order imbalance and commonality: Evidence from the options market

Borsa Istanbul Review, 2022
Using a market model and principal component analysis, we investigate the existence of common effects in order imbalance in the Borsa Istanbul's option market.
John Omole, Ahmet Sensoy, Guzhan Gulay
doaj   +1 more source

Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VII [PDF]

, 2008
Regulation of intracellular cyclic adenosine 3’, 5’-monophosphate (cAMP) by multiple pathways enables differential function of this ubiquitous second messenger in a context dependent manner.
Collins, Julie, Davis, Richard, Fraser, Iain D., Jiang, Lily I., Sternweis, Paul C.   +4 more
core   +2 more sources

Discovery of potent tubulin inhibitors targeting the colchicine binding site via structure-based lead optimization and antitumor evaluation

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
The colchicine binding site of tubulin is a promising target for discovering novel antitumour agents. Previously, we identified 2-aryl-4-amide-quinoline derivatives displayed moderate tubulin polymerisation inhibitory activity and broad-spectrum in vitro
Wei Liu, Youyou He, Zhongjie Guo, Miaomiao Wang, Xiaodong Han, Hairui Jia, Jin He, Shanshan Miao, Shengzheng Wang   +8 more
doaj   +1 more source

Dynamic changes of the extracellular matrix after acute tako-tsubo cardiomyopathy [PDF]

, 2015
Funding Tenovus Scotland.
Ahearn, Trevor, Cameron, Donnie, Dawson, Dana K., Frenneaux, Michael P., Higgins, David M., Horowitz, John, Jagpal, Baljit, Ng, Bernice K., Scally, Caroline   +8 more
core   +1 more source

Modeling S&P500 returns with GARCH models

Latin American Journal of Central Banking, 2023
This paper provides several estimates of the GARCH models’ parameters for the S&P500 index, based on returns and CBOE VIX. Using a daily sample collected from 2007 to 2022, we can conclude that adding the VIX information improves the estimates of the ...
Rodrigo Alfaro, Alejandra Inzunza
doaj   +1 more source