Results 11 to 20 of about 49,842 (194)

Comparative Liquid Biopsy Testing for KRAS Mutations From Plasma Cell-Free DNA (cfDNA) and Extracellular Vesicles in Lung Adenocarcinoma. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background Liquid biopsy has emerged as a promising, minimally invasive tool to detect cancer biomarkers. Extracellular vesicles (EVs) are secreted into biofluids to transport cargo such as DNA and are a potential biosource for liquid biopsy biomarkers.
Zahra CJ, Chee TM, Stephens EKH, Keir EJ, Parris BA, O'Farrell HE, Goldsworthy AF, Bowman RV, Yang IA, Fong KM.   +9 more
europepmc   +2 more sources

Serum-Based KRASG12/G13 Mutation Detection Using Droplet Digital PCR: Clinical Implications and Limitations in Colorectal Adenocarcinoma With Tumor Heterogeneity

Frontiers in Oncology, 2021
BackgroundCell-free DNA (cfDNA) has arisen as an alternative target for evaluating somatic mutations in cancer. KRAS mutation status is critical for targeted therapy in colorectal adenocarcinoma (CRAC).
Ju Seok Kim, Go Eun Bae, Seok-Hwan Kim, Min Kyung Choi, Min-Kyung Yeo   +4 more
doaj   +1 more source

Identification and Characterization of a Potential Probiotic, Clostridium butyricum G13, Isolated from the Intestine of the Mud Crab (Scylla paramamosain)

Microbiology Spectrum, 2023
The butyrate-producing bacterium Clostridium butyricum has been proven to be important in improving the growth and health benefits of aquatic animals. In this study, C.
Huifen Liang, Ngoc Tuan Tran, Taoqiu Deng, Jinkun Li, Yifan Lei, Mohammad Akibul Hasan Bakky, Ming Zhang, Rui Li, Wenxuan Chen, Yueling Zhang, Xiuli Chen, Shengkang Li   +11 more
doaj   +1 more source

G13-dependent Activation of MAPK by Thyrotropin [PDF]

Journal of Biological Chemistry, 2008
Stimulation of the thyrotropin receptor (TSHR) activates G proteins of all four subfamilies (G(s), G(i/o), G(q/11), and G(12/13)). Whereas G(s)/cAMP-dependent cellular responses upon TSHR stimulation are well established, other signaling pathways are less characterized.
Büch, Thomas R. H., Biebermann, Heike, Kalwa, Hermann, Pinkenburg, Olaf, Hager, Denise, Barth, Holger, Aktories, Klaus, Breit, Andreas, Gudermann, Thomas   +8 more
openaire   +3 more sources

Helping to keep History relevant: Multimedia and authentic learning

Journal of Interactive Media in Education, 2009
The subject based curriculum attracts lively debate in many countries being accused of fragmenting teaching and learning, erecting artificial barriers and failing to teach the skills required in the twenty first century (Hazlewood 2005). Cross-curricular
Peter Hillis, Drew Calderhead
doaj   +1 more source

Modeling S&P500 returns with GARCH models

Latin American Journal of Central Banking, 2023
This paper provides several estimates of the GARCH models’ parameters for the S&P500 index, based on returns and CBOE VIX. Using a daily sample collected from 2007 to 2022, we can conclude that adding the VIX information improves the estimates of the ...
Rodrigo Alfaro, Alejandra Inzunza
doaj   +1 more source

Dynamic changes of the extracellular matrix after acute tako-tsubo cardiomyopathy [PDF]

, 2015
Funding Tenovus Scotland.
Ahearn, Trevor, Cameron, Donnie, Dawson, Dana K., Frenneaux, Michael P., Higgins, David M., Horowitz, John, Jagpal, Baljit, Ng, Bernice K., Scally, Caroline   +8 more
core   +1 more source

TSH Activates Macrophage Inflammation by G13- and G15-dependent Pathways

Endocrinology, 2021
AbstractThyroid-stimulating hormone (TSH) treatment activates inhibitor of NF-κB/nuclear factor κB (IκB/NFκB) and extracellular signal-regulated kinase (ERK)–P38 in macrophages, but how these pathways are activated, and how they contribute to the proinflammatory effect of TSH on macrophages remain unknown.
Chongbo Yang, Zhao He, Qunye Zhang, Ming Lu, Jiajun Zhao, Wenbin Chen, Ling Gao   +6 more
openaire   +2 more sources

Discovery of potent tubulin inhibitors targeting the colchicine binding site via structure-based lead optimization and antitumor evaluation

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
The colchicine binding site of tubulin is a promising target for discovering novel antitumour agents. Previously, we identified 2-aryl-4-amide-quinoline derivatives displayed moderate tubulin polymerisation inhibitory activity and broad-spectrum in vitro
Wei Liu, Youyou He, Zhongjie Guo, Miaomiao Wang, Xiaodong Han, Hairui Jia, Jin He, Shanshan Miao, Shengzheng Wang   +8 more
doaj   +1 more source

Oddities of Quantum Colorings [PDF]

, 2016
The main purpose of this work is to collect some interesting facts related to quantum graph coloring. We consider the orthogonality graph of the three-dimensional vectors with entries from the set {-1, 0, 1}. If we ignore the overall sign of the vectors,
Mancinska, Laura, Roberson, David E.
core   +2 more sources