Results 1 to 10 of about 517 (97)
Micromolar Affinity and Higher: Synthetic Host–Guest Complexes with High Stabilities
Angewandte Chemie International Edition, Volume 62, Issue 28, July 10, 2023., 2023 The review collects recent achievements in the design of 1 : 1 host–guest complexes with association constants exceeding 106 M−1. The relationships between the measured thermodynamic constants and the structural parameters of the interacting species are analyzed.
Sayan Sarkar +3 more
wiley +1 more source
Melanoma: Pathogenesis and Targeted Therapy. [PDF]
MedComm (2020)The treatment landscape for advanced melanoma has evolved significantly. BRAF–MEK inhibitor combinations are standard for BRAF‐mutant melanoma, whereas targeting NRAS mutations is more challenging, with MEK inhibitors like tunlametinib emerging as an option.
Fu Y +5 more
europepmc +2 more sources
RAS‐targeted cancer therapy: Advances in drugging specific mutations
MedComm, Volume 4, Issue 3, June 2023., 2023 Personalized therapeutic strategy targeting specific mut‐RAS‐induced cancers is essential. Cancer type, RAS mutation type, activation of downstream pathways, and clinicopathological background should be comprehensively considered when designing strategies for drug combinations.
Cen Liu +7 more
wiley +1 more source
Biological Reviews, Volume 97, Issue 1, Page 251-272, February 2022., 2022 ABSTRACT Sphingosine 1‐phosphate (S1P) is a bioactive sphingolipid metabolite, functioning as a signalling molecule in diverse cellular processes. Over the past few decades, studies of S1P signalling have revealed that the physiological activity of S1P largely depends on S1P metabolizing enzymes, transporters and receptors on the plasma membrane, as ...
Mengqiao Cui +2 more
wiley +1 more source
Ral GTPase–activating protein regulates the malignancy of pancreatic ductal adenocarcinoma
Cancer Science, Volume 112, Issue 8, Page 3064-3073, August 2021., 2021 Ral is a Ras family small GTPase that have recently been noted as a novel signaling factor that regulates progression of pancreatic ductal adenocarcinoma (PDAC). In this study, by characterizing newly generated RalGAP‐deficient PDAC cells, we first demonstrated that Ral GTPase–activating proteins played a critical role in not only cell migration and ...
Shingo Yoshimachi +15 more
wiley +1 more source
The effect of palmitoylation on the function of the alpha subunits of the guanine nucleotide binding proteins G11 and G0 [PDF]
, 1995 Heterotrimeric guanine nucleotide binding proteins function to couple seven transmembrane spanning serpentine receptors to effector systems governing the regulation of intracellular second messengers.
McCallum, John Fraser
core +1 more source
The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families. [PDF]
, 1996 Thyrotropin is the primary hormone that, via one heptahelical receptor, regulates thyroid cell functions such as secretion, specific gene expression, and growth.
Spicher, Karsten +8 more
core +1 more source
Targeting neurotransmitter receptors for central nervous system therapeutics: from molecular signalling to behavioural pharmacology [PDF]
, 2012 EThOS - Electronic Theses Online ServiceGBUnited ...
Newman-Tancredi, Adrian +1 more
core +1 more source
, 2021 ilustraciones, fotografías, gráficasEl litio se ha usado por décadas como estabilizador del estado de ánimo en trastornos bipolares, pero sus mecanismos de acción a nivel celular aun no se han esclarecido.
Mantilla Esparza, Fabián Andrés
core +1 more source