Results 1 to 10 of about 499 (82)
Melanoma: Pathogenesis and Targeted Therapy. [PDF]
MedComm (2020)The treatment landscape for advanced melanoma has evolved significantly. BRAF–MEK inhibitor combinations are standard for BRAF‐mutant melanoma, whereas targeting NRAS mutations is more challenging, with MEK inhibitors like tunlametinib emerging as an option.
Fu Y +5 more
europepmc +2 more sources
Micromolar Affinity and Higher: Synthetic Host–Guest Complexes with High Stabilities
Angewandte Chemie International Edition, Volume 62, Issue 28, July 10, 2023., 2023 The review collects recent achievements in the design of 1 : 1 host–guest complexes with association constants exceeding 106 M−1. The relationships between the measured thermodynamic constants and the structural parameters of the interacting species are analyzed.
Sayan Sarkar +3 more
wiley +1 more source
RAS‐targeted cancer therapy: Advances in drugging specific mutations
MedComm, Volume 4, Issue 3, June 2023., 2023 Personalized therapeutic strategy targeting specific mut‐RAS‐induced cancers is essential. Cancer type, RAS mutation type, activation of downstream pathways, and clinicopathological background should be comprehensively considered when designing strategies for drug combinations.
Cen Liu +7 more
wiley +1 more source
Biological Reviews, Volume 97, Issue 1, Page 251-272, February 2022., 2022 ABSTRACT Sphingosine 1‐phosphate (S1P) is a bioactive sphingolipid metabolite, functioning as a signalling molecule in diverse cellular processes. Over the past few decades, studies of S1P signalling have revealed that the physiological activity of S1P largely depends on S1P metabolizing enzymes, transporters and receptors on the plasma membrane, as ...
Mengqiao Cui +2 more
wiley +1 more source
Ral GTPase–activating protein regulates the malignancy of pancreatic ductal adenocarcinoma
Cancer Science, Volume 112, Issue 8, Page 3064-3073, August 2021., 2021 Ral is a Ras family small GTPase that have recently been noted as a novel signaling factor that regulates progression of pancreatic ductal adenocarcinoma (PDAC). In this study, by characterizing newly generated RalGAP‐deficient PDAC cells, we first demonstrated that Ral GTPase–activating proteins played a critical role in not only cell migration and ...
Shingo Yoshimachi +15 more
wiley +1 more source
Role of miRNA Let-7 and Its Major Targets in Prostate Cancer
BioMed Research International, Volume 2014, Issue 1, 2014., 2014 Prostate cancer is worldwide the sixth leading cause of cancer related death in men thus early detection and successful treatment are still of major interest. The commonly performed screening of the prostate‐specific antigen (PSA) is controversially discussed, as in many patients the prostate‐specific antigen levels are chronically elevated in the ...
Siegfried Wagner +4 more
wiley +1 more source
Role of G Protein‐Coupled Receptors in Control of Dendritic Cell Migration
BioMed Research International, Volume 2014, Issue 1, 2014., 2014 Dendritic cells (DCs) are highly efficient antigen‐presenting cells. The migratory properties of DCs give them the capacity to be a sentinel of the body and the vital role in the induction and regulation of adaptive immune responses. Therefore, it is important to understand the mechanisms in control of migration of DCs to lymphoid and nonlymphoid ...
Yuan Liu, Guixiu Shi, Mina Hur
wiley +1 more source
Genetic and Biochemical Alterations in Non‐Small Cell Lung Cancer
Biochemistry Research International, Volume 2012, Issue 1, 2012., 2012 Despite significant advances in the detection and treatment of lung cancer, it causes the highest number of cancer‐related mortality. Recent advances in the detection of genetic alterations in patient samples along with physiologically relevant animal models has yielded a new understanding of the molecular etiology of lung cancer.
Jackie L. Johnson +3 more
wiley +1 more source
Signal Protein‐Derived Peptides as Functional Probes and Regulators of Intracellular Signaling
Journal of Amino Acids, Volume 2011, Issue 1, 2011., 2011 The functionally important regions of signal proteins participating in their specific interaction and responsible for transduction of hormonal signal into cell are rather short in length, having, as a rule, 8 to 20 amino acid residues. Synthetic peptides corresponding to these regions are able to mimic the activated form of full‐size signal protein and
Alexander O. Shpakov, Andrei Malkov
wiley +1 more source