Results 11 to 20 of about 517 (97)
, 2009 Integrin-mediated adhesion plays a central role in T cell trafficking and activation. Genetic inactivation of the guanine nucleotide-binding (G) protein alpha-subunits Galpha(12) and Galpha(13) resulted in an increased activity of integrin leukocyte ...
Herroeder, S;Reichardt, P;Sassmann, A;Zimmermann, B;Jaeneke, D;Hoeckner, J;Hollmann, MW;Fischer, KD;Vogt, S;Grosse, R;Hogg, N;Gunzer, M;Offermanns, S;Wettschureck, N
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Role of miRNA Let-7 and Its Major Targets in Prostate Cancer
BioMed Research International, Volume 2014, Issue 1, 2014., 2014 Prostate cancer is worldwide the sixth leading cause of cancer related death in men thus early detection and successful treatment are still of major interest. The commonly performed screening of the prostate‐specific antigen (PSA) is controversially discussed, as in many patients the prostate‐specific antigen levels are chronically elevated in the ...
Siegfried Wagner +4 more
wiley +1 more source
Involvement of the Microtubule-Regulated RhoGEF GEF-H1 in the G12 family signaling pathways [PDF]
, 2014 [cat] Les proteïnes G heterotrimèriques són reguladores de l'homeòstasi cel•lular. Coordinen la senyalització entre els receptors acoblats a proteïnes G (GPCR) i els seus efectors intracel.lulars. Hi ha 4 subfamflies de proteïnes G: G-alfa(i), G-alfa(q),
Garrido Antequera, Georgina
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Role of G Protein‐Coupled Receptors in Control of Dendritic Cell Migration
BioMed Research International, Volume 2014, Issue 1, 2014., 2014 Dendritic cells (DCs) are highly efficient antigen‐presenting cells. The migratory properties of DCs give them the capacity to be a sentinel of the body and the vital role in the induction and regulation of adaptive immune responses. Therefore, it is important to understand the mechanisms in control of migration of DCs to lymphoid and nonlymphoid ...
Yuan Liu, Guixiu Shi, Mina Hur
wiley +1 more source
Genetic and Biochemical Alterations in Non‐Small Cell Lung Cancer
Biochemistry Research International, Volume 2012, Issue 1, 2012., 2012 Despite significant advances in the detection and treatment of lung cancer, it causes the highest number of cancer‐related mortality. Recent advances in the detection of genetic alterations in patient samples along with physiologically relevant animal models has yielded a new understanding of the molecular etiology of lung cancer.
Jackie L. Johnson +3 more
wiley +1 more source
Signal Protein‐Derived Peptides as Functional Probes and Regulators of Intracellular Signaling
Journal of Amino Acids, Volume 2011, Issue 1, 2011., 2011 The functionally important regions of signal proteins participating in their specific interaction and responsible for transduction of hormonal signal into cell are rather short in length, having, as a rule, 8 to 20 amino acid residues. Synthetic peptides corresponding to these regions are able to mimic the activated form of full‐size signal protein and
Alexander O. Shpakov, Andrei Malkov
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Genome-Wide Proteomics and Quantitative Analyses on Halophilic Archaea [PDF]
, 2008 The aerobic, haloalkaliphilic archaeon Natronomonas pharaonis is able to survive in salt-saturated lakes of pH 11. With genome-wide shotgun proteomics, 886 soluble proteins (929 proteins in total) of the theoretical Natronomonas pharaonis soluble ...
Konstantinidis, Konstantinos +1 more
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Advanced Science, Volume 12, Issue 30, August 14, 2025.KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma +9 more
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Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
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, 2009 Data source: Supplementary data, https://doi.org/10.1016/j.bbalip.2009.01.019Sphingosine-1-phosphate (S1P), formed by sphingosine kinases (SphKs), regulates cellular proliferation and migration by acting as an agonist at specific receptors or ...
Liphardt, K. +8 more
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