Results 21 to 30 of about 14,047 (215)
Gq/G11- und G12/G13-Protein-vermittelte Signaltransduktion im Kontext kardiovaskulärer Erkrankungsprozesse [PDF]
, 2021 G-Protein-vermittelte Signalwege spielen eine zentrale Rolle bei einer Vielzahl physiologischer und pathologischer Prozesse. Der Fokus dieser Arbeit liegt auf den G-Protein-Familien Gq/G11 und G12/G13 und deren Funktion im Kontext kardiovaskulärer ...
Althoff, Till
core +1 more source
Helping to keep History relevant: Multimedia and authentic learning
Journal of Interactive Media in Education, 2009 The subject based curriculum attracts lively debate in many countries being accused of fragmenting teaching and learning, erecting artificial barriers and failing to teach the skills required in the twenty first century (Hazlewood 2005). Cross-curricular
Peter Hillis, Drew Calderhead
doaj +1 more source
Modeling S&P500 returns with GARCH models
Latin American Journal of Central Banking, 2023 This paper provides several estimates of the GARCH models’ parameters for the S&P500 index, based on returns and CBOE VIX. Using a daily sample collected from 2007 to 2022, we can conclude that adding the VIX information improves the estimates of the ...
Rodrigo Alfaro, Alejandra Inzunza
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Order imbalance and commonality: Evidence from the options market
Borsa Istanbul Review, 2022 Using a market model and principal component analysis, we investigate the existence of common effects in order imbalance in the Borsa Istanbul's option market.
John Omole, Ahmet Sensoy, Guzhan Gulay
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Economics and Business Review, 2020 In this paper an extension of the well-known binomial approach to option pricing is presented. The classical question is: What is the price of an option on the risky asset?
Bieta Volker, Broll Udo, Siebe Wilfried
doaj +1 more source
Insights into divalent cation regulation and G13-coupling of orphan receptor GPR35
Cell Discovery, 2022 Endogenous ions play important roles in the function and pharmacology of G protein-coupled receptors (GPCRs) with limited atomic evidence. In addition, compared with G protein subtypes Gs, Gi/o, and Gq/11, insufficient structural evidence is accessible ...
Jia Duan +12 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 The colchicine binding site of tubulin is a promising target for discovering novel antitumour agents. Previously, we identified 2-aryl-4-amide-quinoline derivatives displayed moderate tubulin polymerisation inhibitory activity and broad-spectrum in vitro
Wei Liu +8 more
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Conformational Activation of Radixin by G13 Protein α Subunit [PDF]
Journal of Biological Chemistry, 2000 G(13) protein, one of the heterotrimeric guanine nucleotide-binding proteins (G proteins), regulates diverse and complex cellular responses by transducing signals from the cell surface presumably involving more than one pathway. Yeast two-hybrid screening of a mouse brain cDNA library identified radixin, a member of the ERM family of three closely ...
R, Vaiskunaite +5 more
openaire +2 more sources
Rapid Fragment Screening by 19F Steady‐State Free Precession NMR
Angewandte Chemie, EarlyView.19F$^{19}{\rm F}$ SSFP NMR is a broadband and very sensitive experiment for detecting protein–ligand interactions. The method enables rapid fragment screening at low micromolar protein concentrations, even for challenging drug targets such as intrinsically disordered proteins.
Laura Ruduša +8 more
wiley +2 more sources
An Assessment of Wind Farm Construction Efficiency Using the Real Option Method
Folia Oeconomica Stetinensia, 2016 From a developer’s point of view the construction of a wind farm in Poland is an investment project assessed in terms of economic efficiency. This paper discusses the selection of methods to be used for the assessment of such investments: it proposes to ...
Łukaszewski Tomasz, Głoćko Wojciech
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