Results 241 to 250 of about 7,531,916 (333)

Reprogramming the pluripotent cell cycle: Restoration of an abbreviated G1 phase in human induced pluripotent stem (iPS) cells

Journal of Cellular Physiology, 2011
Prachi N. Ghule, R. Medina, C. Lengner, M. Mandeville, Meng Qiao, Z. Dominski, J. Lian, J. Stein, A. V. van Wijnen, G. Stein   +9 more
semanticscholar   +1 more source

Endometrial Epithelial Lactate Deficiency Drives CD8+ T‐Cells Dysregulation in Unexplained Recurrent Implantation Failure

Advanced Science, EarlyView.
Unexplained recurrent implantation failure (RIF) represents a significant clinical challenge. Our results demonstrate that reduced lactate production in the RIF endometrium impairs the suppression of cytotoxic CD8+ T‑cells, allowing their proliferation and thereby disrupting the local immune balance essential for successful embryo implantation.
Yuanlin He, Kang Ke, Qingxia Meng, Yichun Guan, Jichun Tan, Hong Lv, Boxian Huang, Chan Tian, Qinyan Zou, Mingxing An, Yao Gao, Jingjing Chen, Xiaoyu Wei, Xi Wang, Hongxia Ma, Yuan Lin, Feiyang Diao, Yayun Gu, Zhibin Hu   +18 more
wiley   +1 more source

A Hydrogen‐Releasing Nanozyme Engineers a Mitochondrial ROS Amplifier for Self‐Sustaining Catalytic Immunotherapy

Advanced Science, EarlyView.
We developed a RhPd‐H nanozyme that integrates enhanced POD‐mimetic catalytic activity with thermally triggered H2 release. H2 shields and reprograms mitochondria to continuously leak endogenous ·O2−. This dual‐path ROS spatially and temporally disrupts redox homeostasis, inducing persistent oxidative stress for tumor suppression and antitumor immunity,
Mingfan Shi, Jingrui Cao, Tong Wu, Guang Yang, YaWen Yang, Shixin Zhang, Wenwen Su, Hongyu Chu, Yangyang Zhao, Shan Jiang, Qiong Wu, Dongxu Jiao, Fangfang Chen   +12 more
wiley   +1 more source

H3.3 is deposited at centromeres in S phase as a placeholder for newly assembled CENP-A in G1 phase

The Nucleus, 2011
Elaine M. Dunleavy, G. Almouzni, G. Karpen   +2 more
semanticscholar   +1 more source

Cells Dynamically Adapt Their Nuclear Volumes and Proliferation Rates During Single to Multicellular Transitions

Advanced Science, EarlyView.
It is currently not well understood how cells regulate basic properties, e.g., volume and mechanics within dense multicellular environments like tumors. Here, we show that different cell types of cancer and also normal cells largely decrease their nuclear and cellular volumes in emerging cell clusters and that this is partly driven by cell cycle shifts.
Vaibhav Mahajan, Keshav Gajendra Babu, Markus Mukenhirn, Antje Garside, Vinita Ajit Kini, Trishla Adhikari, Timon Beck, Byung Ho Lee, Kyoohyun Kim, Carsten Werner, Raimund Schlüßler, Alf Honigmann, Sebastian Aland, Anna Verena Taubenberger   +13 more
wiley   +1 more source

Bioactivity-Guided Fractionation and Mechanistic Insights into <i>Aristolochia ringens</i> Root Extract-Induced G₁ Phase Arrest and Mitochondria-Mediated Apoptosis in Human Colon Adenocarcinoma Cells. [PDF]

Pharmaceuticals (Basel)
Anifowose SO, Salih AM, Oladejo MK, Rady A, Al Mosallam MS, Aljohi HA, Almansour MI, Alkahtani SH, Alanazi IO, Al-Dahmash BA.   +9 more
europepmc   +1 more source

Arbitrary Orthogonal Polarization Decomposition and Routing With Complex Amplitude Modulation via Wheel‐of‐Fortune‐Inspired Metasurfaces

Advanced Science, EarlyView.
This work demonstrates a receiver‐transmitter‐integrated metasurface that decomposes an incident wave into orthogonal components and routes them into separate channels. Inspired by a “Wheel‐of‐Fortune” mechanism, it enables independent control over the amplitude, phase, and polarization of the transmitted wave.
Tong Liu, Changhong Dai, Weike Feng, Yanzhao Wang, Wenxin Liu, Wentao Zhang, Chao Tian, Guangwei Hu, He‐Xiu Xu   +8 more
wiley   +1 more source

Acyl-coenzyme A: cholesterol acyltransferase inhibitor avasimibe suppresses tumorigenesis and induces G1-phase cell-cycle arrest by activating PPARγ signaling pathway in bladder cancer. [PDF]

J Cancer
Peng T, Xiong K, He Z, Cheng S, Chen S, Chen S, Yang Z, Xiang W, Ju L, Zhang Y, Qian K, Xiao Y, Wang G.   +12 more
europepmc   +1 more source

Cell Cycle‐Specific Regulation of Centrosome Clustering Dynamics in Cancer Cells by the Multifunctional Kinesin HSET

Advanced Science, EarlyView.
CDK5RAP2 associates with the kinesin HSET and forms co‐condensates. HSET motors drive the directional transport of CDK5RAP2 condensates toward microtubule minus ends. During mitosis, HSET self‐assembly further stabilizes clustered centrosomes, thereby enabling pseudo‐bipolar spindle formation in cancer cells with supernumerary centrosomes. Upon mitotic
Po‐Pang Chen, Athira Saju, Chia‐Chou Wu, Tzu‐Han Weng, Su‐Yi Tsai, Tzu‐Lun Huang, Jia‐Ying Su, Chien‐Ling Lin, Yu‐Chun Lin, See‐Yeun Ting, Sheng‐hong Chen, Kuo‐Chiang Hsia   +11 more
wiley   +1 more source

Bisphenol A suppresses colon epithelial cell responses via G₀/G₁-phase arrest, MAPK and PI3K/AKT pathway modulation, and MMP-2/9 Inhibition by upregulating p21WAF1. [PDF]

Sci Rep
Song JH, Lee D, Hwang B, Kim S, Kim J, Park S, Choo S, Hwang SK, Kim H, Yun SJ, Choi YH, Kim WJ, Moon SK.   +12 more
europepmc   +1 more source