Results 161 to 170 of about 39,406 (258)

REV1 Loss Triggers a G2/M Cell-Cycle Arrest Through Dysregulation of Mitotic Regulators. [PDF]

Genes (Basel)
Buntin B, Guyette M, Gupta V, Ikeh K, Bhattacharya S, Lamkin EN, Lafuze A, Del Rio-Guerra R, Hong J, Zhou P, Chatterjee N.   +10 more
europepmc   +1 more source

Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice

Aging Cell, Volume 25, Issue 2, February 2026.
Comprehensive transcriptomic profiling of eight mouse organs across six ages reveals how aging reshapes biological processes. Trajectory and network analyses distinguish shared and organ‐specific signatures, charting the molecular landscape of systemic aging.
Sarah Morsy, Enzo Scifo, Kan Xie, Kristina Schaaf, Jenny Russ, Stefan Paulusch, Elena De Domenico, Paolo Salomoni, Daniele Bano, Dan Ehninger   +9 more
wiley   +1 more source

Targeting CDK12/13 Drives Mitotic Arrest to Overcome Resistance to KRASG12C Inhibitors. [PDF]

Cancer Res
Stern YE, Ghosh P, Peroza J, Solanki HS, Imbody D, Bridenstine L, Pandurangan T, Frydman SM, Nickens KN, Walker-Mimms HL, Suvarna K, Chaudhary N, Monastyrskyi A, Duckett D, Haura EB.   +14 more
europepmc   +1 more source

Role of Dot1-Dependent Histone H3 Methylation in G1 and S Phase DNA Damage Checkpoint Functions of Rad9

Molecular and Cellular Biology, 2005
R. Wysocki, A. Javaheri, S. Allard, Fei Sha, J. Côté, S. Kron   +5 more
semanticscholar   +1 more source

Rapamycin Exerts Its Geroprotective Effects in the Ageing Human Immune System by Enhancing Resilience Against DNA Damage

Aging Cell, Volume 25, Issue 2, February 2026.
Using in vitro DNA damage assays in human T cells, ex vivo profiling of aged immune subsets and a small placebo‐controlled in vivo study, authors show that low‐dose rapamycin, a potent life‐extending mTOR inhibitor, enhances resilience against DNA damage in the human immune system.
Loren Kell, Eleanor J. Jones, Nima Gharahdaghi, Daniel J. Wilkinson, Kenneth Smith, Philip J. Atherton, Anna K. Simon, Lynne S. Cox, Ghada Alsaleh   +8 more
wiley   +1 more source

Evidence for Quasi-High-LET Biological Effects in Clinical Proton Beams That Suppress c-NHEJ and Enhance HR and Alt-EJ. [PDF]

Cells
Mladenov E, Pressler M, Mladenova V, Soni A, Li F, Heinzelmann F, Esser JN, Hessenow R, Gkika E, Jendrossek V, Timmermann B, Stuschke M, Iliakis G.   +12 more
europepmc   +1 more source

TGM2 Regulates Radiosensitivity via POGZ‐Mediated Repair of DNA Double‐Strand Breaks in Cervical Cancer

Cancer Science, Volume 117, Issue 2, Page 429-444, February 2026.
The present study revealed for the first time that TGM2 could regulate the radiosensitivity of cervical cancer via POGZ‐mediated DNA DSB repair. Our findings revealed that TGM2 regulates the radiosensitivity of cervical cancer and demonstrated that POGZ serves as a bridge linking TGM2 to the DNA damage repair process, and suggested a novel mechanistic ...
Yunbo Chi, Peng Dong, Ning Zhang, Baocai Liu, Qian Wang, Guanghui Cheng   +5 more
wiley   +1 more source

MASTL Promotes Hepatocellular Carcinoma Progression and Paclitaxel Resistance Through Mitotic Catastrophe

Cancer Science, Volume 117, Issue 2, Page 377-392, February 2026.
MASTL drives hepatocellular carcinoma (HCC) progression and paclitaxel resistance by triggering mitotic catastrophe. Depletion of MASTL induces DNA damage and promotes mitotic catastrophe, leading to cell death in HCC. MASTL‐mediated mitotic catastrophe depends on PP2A‐B55α activity, suggesting a novel therapeutic target for overcoming chemotherapy ...
Ke Wang, Ziwei Fu, Chuan Xiong, Jing Zhang, Qiang Luo   +4 more
wiley   +1 more source

Overcoming Therapeutic Resistance in Triple-Negative Breast Cancer: Targeting the Undrugged Kinome. [PDF]

Int J Mol Sci
Lee CH, Minh Nguyen T, Lee Y, Choi SG, Nguyen PN, Park JH, Park MK.   +6 more
europepmc   +1 more source

The novel DNA damage checkpoint protein Ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast

EMBO Journal, 1997
M. P. Longhese, V. Paciotti, R. Fraschini, Raffaella Zaccarini, P. Plevani, G. Lucchini   +5 more
semanticscholar   +1 more source