Results 181 to 190 of about 57,844 (267)

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

L1CAM Promotes the Infiltrative Properties of Patient‐Derived Glioblastoma Cells

Cancer Science, Volume 117, Issue 5, Page 1380-1396, May 2026.
In vivo validation of L1CAM‐mediated GBM infiltration. Orthotopic transplantation of L1CAM‐expressing GBM cells into mouse brains demonstrated that L1CAM significantly promotes tumor cell infiltration and expansion in the brain parenchyma, confirming its critical role in the aggressive progression of GBM.
Asako Katsuma, Daisuke Kanematsu, Yukako Handa, Tomoko Shofuda, Atsuyo Yamamoto, Kayo Nishitani, Zhize Xiao, Daisuke Kawauchi, Kentarou Baba, Naoyuki Inagaki, Yonehiro Kanemura   +10 more
wiley   +1 more source

SCL15 Promotes Seed Longevity Acquisition in Arabidopsis thaliana by Enhancing Antioxidant and Repair Mechanisms During Maturation

Physiologia Plantarum, Volume 178, Issue 3, May/June 2026.
ABSTRACT To ensure seed longevity and successful germination, orthodox seeds acquire protective and repair mechanisms during the late stage of seed development to counteract the detrimental effects of desiccation and subsequent rehydration, processes often associated with oxidative stress.
Ming‐Jun Gao, Cathy Coutu, Qi Chen, Myrtle Harrington, Rong Zhou, Dwayne Hegedus   +5 more
wiley   +1 more source

The principles of systems biology

Experimental Physiology, Volume 111, Issue 5, Page 2438-2448, 1 May 2026.
Abstract Physiological interpretations of Systems Biology have made many advances since the Principles of Systems Biology were first published in this journal in 2008. Those advances show that the main principle, Biological Relativity, is a logical necessity since no system can exist without the form of the system.
Denis Noble, Reine Bourret
wiley   +1 more source

p21 Knockdown as a Therapeutic Strategy for Focal Cartilage Injury Repair

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Intraarticular injection of lentiviral p21 shRNA (targeting Cdkn1a) into murine knees with full‐thickness cartilage defects reduces chondrocyte senescence while enhancing matrix repair with minimal hepatic off‐target effects. ABSTRACT Focal articular cartilage defects lack intrinsic regenerative capacity and can progress to osteoarthritis as no ...
Leila Larijani, Aria Ahadzadeh Ardebili, Nini Ortiz Vales, Andreas T. Stürmer, Roman J. Krawetz   +4 more
wiley   +1 more source

Slx4 and Fun30/SMARCAD1 coordinate S-phase checkpoint regulation and replication fork protection in response to Top1-DNA crosslinks. [PDF]

Nucleic Acids Res
Courtes M, Boissière T, Barthe A, Pasero P, Pardo B.   +4 more
europepmc   +1 more source

Investigating the role of higher order chromatin structure and DNA damage complexity on ATM signalling and G2/M checkpoint arrest [PDF]

, 2011
In response to DNA double stranded breaks (DSBs), mammalian cells have evolved two major repair pathways, DNA Non Homologous End Joining (NHEJ) and Homologous Recombination (HR). The majority of DSB repair in G1 and G2 phase is repaired with fast kinetics by NHEJ in a pathway that involves the core NHEJ factors: Ku, DNA-PKcs, XLF, DNA Ligase IV and ...
openaire  

Tumor cell cycle regulation: integrated perspective of stage characteristics, regulatory networks, and signaling pathway intervention strategies. [PDF]

Mol Biomed
Wan Q, Yang Z, Huang L, Xia Y, Long L, Xu Z, Li J.   +6 more
europepmc   +1 more source

Acrylamide disrupts meiotic G2/M transition and SAC activity during oocyte maturation. [PDF]

Biol Direct
Chen S, Wang PX, Wang YT, Ke XH, Ou M, Sun SC, Liao BY, Chen X.   +7 more
europepmc   +1 more source

The Multifaceted Role of Rad9 in the DNA Damage Response of Saccharomyces cerevisiae. [PDF]

Yeast
Kiely A, O'Halloran F, Young P, Lowndes NF, Grenon M, Finn K.   +5 more
europepmc   +1 more source