Results 171 to 180 of about 57,844 (267)

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song, Jingyang Liu, Xue Wang, Minpu Zhang, Changgang Sun   +4 more
wiley   +1 more source

Next‐Generation Sustainable Food Production Through Integrative Biotechnology, AI, and Climate‐Resilient Innovations

Food and Energy Security, Volume 15, Issue 3, May/June 2026.
ABSTRACT By 2050, the global population is projected to reach ~10 billion, leading to 50% increase in food demand. This growth will place immense pressure on agricultural systems that are already struggling with the impacts of climate change and resource depletion.
Chaquayla Katam, Hajra Maqsood, Brooke Bucci, Sixue Chen   +3 more
wiley   +1 more source

The role of cell cycle regulation in cancer [PDF]

, 2008
During the past decades, cancer research has expanded rapidly due to the relatively high incidence rate of cancer and high death rate linked to it. The type and the extent of aggressiveness of particular cancers are determined by specific flaws in the ...
Blundell, Renald, Xuereb, J.
core  

JS-K activates G2/M checkpoints through the DNA damage response and induces autophagy via CAMKKβ/AMPKα/mTOR pathway in bladder cancer cells

Journal of Cancer
The aim of this study was to investigate the effects of JS-K, a nitric oxide donor prodrug, on DNA damage and autophagy in bladder cancer (BCa) cells and to explore the potential related mechanisms. Through detecting proliferation viability, cell morphology observation and colony formation assay low concentrations of JS-K significantly inhibited BCa ...
Zhao, Yuwan, Lin, Shanhong, Zeng, Wenfeng, Lin, Xinghua, Qin, Xingzhang, Miu, Bailiang, Gao, Sheng, Wu, Haokai, Liu, Jianjun, Chen, Xiaojun   +9 more
openaire   +2 more sources

Curcumin Nanoformulations for Dermatological Applications: From Nutraceuticals to Nanocarriers

Food Frontiers, Volume 7, Issue 3, May 2026.
Nanotechnology‐based delivery platforms enhance the cutaneous administration of curcumin. Loading free curcumin into polymeric micelles, metal‐based nanoparticles, nanogels/hydrogels, liposomes, polymeric nanoparticles, or nanoemulsions/nanocrystals helps address its low solubility, poor stability and limited skin permeation. As a result, these systems
Stephany Celeste Gutiérrez‐Ruiz, Alejandra Romero‐Montero, Hector Hernández‐Parra, Sheila I. Peña‐Corona, Héctor Adrián García‐Gasca, Katya Carbone, Fabio Gervasi, Shivaprasad Shetty Mangalpady, Rajesh Kaverikana, Mariia Shanaida, Volodymyr Shanaida, Daniela Calina, Javad Sharifi‐Rad, Gerardo Leyva‐Gómez   +13 more
wiley   +1 more source

Geminin deficiency enhances survival in a murine medulloblastoma model by inducing apoptosis of preneoplastic granule neuron precursors [PDF]

, 2017
Dearborn, Joshua, Kroll, Kristen L, Lewis, Emily M, Patterson, Ethan, Rubin, Joshua B, Sankar, Savita, Tong, Caili, Waller, Laura E, Wozniak, David   +8 more
core   +2 more sources

Saikosaponin A Inhibits Migration/Invasion and Triggers Cell‐Cycle Arrest and Autophagy‐Induced Cell Death in HCT116 Cells and In Vivo

Food Frontiers, Volume 7, Issue 3, May 2026.
Saikosaponin A from Radix Bupleuri inhibited colorectal cancer HCT116 cells with low toxicity. SSA induced S/G2‐M cell cycle arrest and triggered autophagy via mTOR inhibition. SSA suppressed metastasis by blocking PI3K/AKT signaling pathway. SSA significantly reduced tumor growth without apparent toxicity.
Xiu‐Xiu Zhang, Wang‐Wei Zhang, Run‐Hui Ma, Zhi‐Jing Ni, Kiran Thakur, Mohammad Rizwan Khan, Jian‐Guo Zhang, Zhao‐Jun Wei   +7 more
wiley   +1 more source

Resveratrol for Cancer Radio‐Sensitization: Ready for Prime Time or Future Perspective

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Resveratrol exerts antioxidant and anti‐inflammatory effects by reducing reactive oxygen species and suppressing NF‐κB and JAK/STAT signaling pathways. It modulates metabolic signaling through AMPK‐dependent inhibition of mTOR, influencing cell survival and inflammatory responses.
Maryam Fallah, Ali Soleimani, Ali Nouri, Melika Fallah, Alireza Haghighi, Ahmad Reza Dehpour, Abolfazl Zendehdel, Soraiya Ebrahimpour‐Koujan   +7 more
wiley   +1 more source

Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications

MedComm, Volume 7, Issue 5, May 2026.
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang, Xiaoqing Wang, Kai Luo, Tikam Chand Dakal, He Bai, Caiming Xu, Guixin Zhang   +6 more
wiley   +1 more source

A Novel Mechanism of Salvianolic Acid B in Postmyocardial Infarction Cardiac Protection: PHB1‐Driven Raf‐ERK Pathway Activation Promotes Cardiomyocyte Mitosis

MedComm, Volume 7, Issue 5, May 2026.
SalB binds to the C‐terminal of PHB1/2 heterodimer, inducing a conformational change that enhances Raf‐ERK pathway activation via Akt‐mediated phosphorylation, thereby promoting cardiomyocyte mitosis. ABSTRACT Heart failure (HF) following myocardial infarction remains a leading cause of global morbidity and mortality, necessitating novel therapeutic ...
Ce Cao, Bo Ma, Jian Zhang, Lili Yang, Zixin Liu, Haoran Li, Jianshu Song, Keer Zhang, Lei Li, Jianhua Fu, Jianxun Liu   +10 more
wiley   +1 more source