PLoS ONE, 2013 Silica nanoparticles have become promising carriers for drug delivery or gene therapy. Endothelial cells could be directly exposed to silica nanoparticles by intravenous administration. However, the underlying toxic effect mechanisms of silica nanoparticles on endothelial cells are still poorly understood.
Junchao Duan +7 more
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PLK1 or WEE1 inhibition targets homologous recombination repair proficiency in BRCA1/2 wild-type high-grade serous ovarian cancer [PDF]
Cell Death and DiseaseHigh-grade serous ovarian cancer (HGSOC) is a poor prognostic disease, especially in BRCA1/2 wild-type (BRCA-WT) patients with homologous recombination (HR) proficiency.
Qian Xi +16 more
doaj +2 more sources
Cdk1 Protein-mediated Phosphorylation of Receptor-associated Protein 80 (RAP80) Serine 677 Modulates DNA Damage-induced G2/M Checkpoint and Cell Survival [PDF]
Journal of Biological Chemistry, 2012 Post-translational phosphorylation plays critical roles in the assembly of signaling and repair proteins in the DNA damage response pathway. RAP80, a component of the BRCA1-A complex, is crucial in cell cycle checkpoint activation and DNA damage repair. However, its molecular mechanism is unclear.
Hyun Jung Cho +8 more
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Deoxycytidine kinase regulates the G2/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damage [PDF]
Nucleic Acids Research, 2012 Deoxycytidine kinase (dCK) is a rate limiting enzyme critical for phosphorylation of endogenous deoxynucleosides for DNA synthesis and exogenous nucleoside analogues for anticancer and antiviral drug actions. dCK is activated in response to DNA damage; however, how it functions in the DNA damage response is largely unknown.
Chunying Yang +11 more
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DNA Damage-induced G2/M Checkpoint in SV40 Large T Antigen-immortalized Embryonic Fibroblast Cells Requires SHP-2 Tyrosine Phosphatase [PDF]
Journal of Biological Chemistry, 2003 DNA damage induced by radiation or DNA-damaging agents leads to apoptosis and cell cycle arrest. However, DNA damage-triggered signal transduction involved in these cellular responses is not well understood. We previously demonstrated an important role for SHP-2, a ubiquitously expressed SH2 domain-containing tyrosine phosphatase, in the DNA damage ...
Liangping Yuan +2 more
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The BRCA1 ring domain is essential for DNA damage repair and G2/M checkpoint activation
, 2014 The BRCA1 (breast cancer 1, early onset) tumor suppressor gene is involved in a variety of cellular pathways, and is an essential factor for normal DNA repair by homologous recombination. The BRCA1 protein has a number of conserved domains, including a coiled-coil domain, two BRCT domains and an N-terminal RING (Really Interesting New Gene) domain ...
Ali Al Hamza
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c-Abl Phosphorylates Plk1 in Facilitating DNA Damage-Induced G2/M Checkpoint Release with a Trade-off of Micronuclei Formation [PDF]
AbstractDNA double-strand breaks (DSBs) pose a critical threat to cellular proliferation and genomic integrity. Upon genotoxic stress, the DNA damage response (DDR) rapidly activates repair pathways and halts cell cycle progression through checkpoint activation.
V Meltser +4 more
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Investigating the role of higher order chromatin structure and DNA damage complexity on ATM signalling and G2/M checkpoint arrest [PDF]
, 2011 In response to DNA double stranded breaks (DSBs), mammalian cells have evolved two major repair pathways, DNA Non Homologous End Joining (NHEJ) and Homologous Recombination (HR). The majority of DSB repair in G1 and G2 phase is repaired with fast kinetics by NHEJ in a pathway that involves the core NHEJ factors: Ku, DNA-PKcs, XLF, DNA Ligase IV and ...
Holly Brunton
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ZGRF1 promotes end resection of DNA homologous recombination via forming complex with BRCA1/EXO1
Cell Death Discovery, 2021 To maintain genomic stability, the mammalian cells has evolved a coordinated response to DNA damage, including activation of DNA repair and cell cycle checkpoint processes.
Shuang Yan +9 more
doaj +1 more source