Results 41 to 50 of about 39,406 (258)

AMPK Activity Contributes to G2 Arrest and DNA Damage Decrease via p53/p21 Pathways in Oxidatively Damaged Mouse Zygotes

Frontiers in Cell and Developmental Biology, 2020
In zygotes, the capacity of G2/M checkpoint and DNA repair mechanisms to respond to DNA damage varies depending on different external stressors. In our previous studies, we found that mild oxidative stress induced a G2/M phase delay in mouse zygotes ...
Pei He, Pei He, Pei He, Zhiling Li, Zhiling Li, Zhiling Li, Feng Xu, Gaizhen Ru, Yue Huang, En Lin, Sanfeng Peng   +10 more
doaj   +1 more source

Programmed cell death 11 modulates but not entirely relies on p53-HDM2 loop to facilitate G2/M transition in colorectal cancer cells

Oncogenesis, 2023
We previously described a nucleolar protein RSL1D1 but distributed throughout the nucleus in HCT116 colorectal cancer (CRC) cells to facilitate G1/S transition by inhibiting p53 signaling.
Li Ding, Yujie Xu, Lin Xu, Chenhong Zhao, Zhiping Zhang, Jie Zhang, Kai Liao, Yuerou Chen, Jingwen Li, Xinyu Mei, Xinyue Zhang   +10 more
doaj   +1 more source

Myt1 overexpression mediates resistance to cell cycle and DNA damage checkpoint kinase inhibitors

Frontiers in Cell and Developmental Biology, 2023
Cell cycle checkpoint kinases serve as important therapeutic targets for various cancers. When they are inhibited by small molecules, checkpoint abrogation can induce cell death or further sensitize cancer cells to other genotoxic therapies. Particularly
Sargun Sokhi, C. W. Lewis, Amirali B. Bukhari, Joanne D. Hadfield, Edric J. Xiao, Jeremy Fung, Yea Jin Yoon, Wen-Hsin Hsu, A. Gamper, Gordon K. Chan   +9 more
semanticscholar   +1 more source

FRET-Based Sorting of Live Cells Reveals Shifted Balance between PLK1 and CDK1 Activities During Checkpoint Recovery

Cells, 2020
Cells recovering from the G2/M DNA damage checkpoint rely more on Aurora A-PLK1 signaling than cells progressing through an unperturbed G2 phase, but the reason for this discrepancy is not known.
Lorenzo Lafranchi, Erik Müllers, Dorothea Rutishauser, Arne Lindqvist   +3 more
doaj   +1 more source

NFBD1/MDC1 is phosphorylated by PLK1 and controls G2/M transition through the regulation of a TOPOIIα-mediated decatenation checkpoint. [PDF]

PLoS ONE, 2013
Although it has been established that nuclear factor with BRCT domain 1/ mediator of the DNA damage checkpoint protein 1 (NFBD1/MDC1) is closely involved in DNA damage response, its possible contribution to the regulation of cell- cycle progression is ...
Kiyohiro Ando, Toshinori Ozaki, Toru Hirota, Akira Nakagawara   +3 more
doaj   +1 more source

Blocking CHK1 Expression Induces Apoptosis and Abrogates the G2 Checkpoint Mechanism

Neoplasia: An International Journal for Oncology Research, 2001
Checkpoint kinase 1 (Chki) is a checkpoint gene that is activated after DNA damage. It phosphorylates and inactivates the Cdc2 activating phosphatase Cdc25C. This in turn inactivates Cdc2, which leads to G2/M arrest.
Yan Luo, Shayna K. Rockow-Magnone, Paul E. Kroeger, Leigh Frost, Zehan Chen, Edward K.-H. Han, Shi-Chung Ng, Robert L. Simmer, Vincent L. Giranda   +8 more
doaj   +1 more source

Pathways for Genome Integrity in G2 Phase of the Cell Cycle

Biomolecules, 2012
The maintenance of genome integrity is important for normal cellular functions, organism development and the prevention of diseases, such as cancer. Cellular pathways respond immediately to DNA breaks leading to the initiation of a multi-facetted DNA ...
Claus Storgaard Sørensen, Tobias Menzel, Arne Nedergaard Kousholt   +2 more
doaj   +1 more source

Ddc2 mediates Mec1 activation through a Ddc1- or Dpb11-independent mechanism.

PLoS Genetics, 2014
The protein kinase Mec1 (ATR ortholog) and its partner Ddc2 (ATRIP ortholog) play a key role in DNA damage checkpoint responses in budding yeast. Previous studies have established the model in which Ddc1, a subunit of the checkpoint clamp, and Dpb11 ...
Amitava Bandhu, John Kang, Kenzo Fukunaga, Greicy Goto, Katsunori Sugimoto   +4 more
doaj   +1 more source

WEE1 kinase is a therapeutic vulnerability in CIC-DUX4 undifferentiated sarcoma

JCI Insight, 2022
CIC-DUX4 rearrangements define an aggressive and chemotherapy-insensitive subset of undifferentiated sarcomas. The CIC-DUX4 fusion drives oncogenesis through direct transcriptional upregulation of cell cycle and DNA replication genes.
Rovingaile Kriska M. Ponce, Nicholas J. Thomas, Nam Q. Bui, Tadashi Kondo, Ross A. Okimoto   +4 more
doaj   +1 more source

Impairment of RAD17 Functions by miR-506-3p as a Novel Synthetic Lethal Approach Targeting DNA Repair Pathways in Ovarian Cancer

Frontiers in Oncology, 2022
Epithelial ovarian cancer (EOC) remains the most lethal gynecological cancer and development of chemo-resistance is a major factor in disease relapse.
Marina Bagnoli, Roberta Nicoletti, Monica Valitutti, Andrea Rizzo, Alessandra Napoli, Rafaela Montalvão De Azevedo, Antonella Tomassetti, Delia Mezzanzanica   +7 more
doaj   +1 more source