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Agonistic and antagonistic properties of CD40 mAb G28-5 are dependent on binding valency.
Circulatory shock, 1995CD40 functional responses can be triggered by binding of mAb G28-5. Here we show that G28-5 induces partial CD40 responses and functions as a partial antagonist of natural CD40 ligand, gp39, by preventing gp39 binding. Fab fragments of G28-5 retain inhibitory activity but lose crosslinking-dependent stimulatory activity.
J A, Ledbetter +4 more
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The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements. They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
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The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements. They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
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The “Dragon” Nebula G28.34+0.06
2014This chapter presents new SMA and JVLA observations of an infrared dark cloud G28.34+0.06. Located in the quiescent southern part of the G28.34 cloud, the region of interest is a massive (\(>\) \(10^3\) \(M_{\odot }\)) molecular clump P1 with a luminosity of \(\sim \) \(10^3\) \(L_{\odot }\), where our previous SMA observations at 1.3 mm have revealed ...
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Critical reviews in immunology, 1998
A single-chain Fv (sFv) was expressed from the variable regions of the CD40-specific mAb G28-5. The molecule bound CD40 with a high affinity (2.2 nM) and was a monomer in solution. Surprisingly, G28-5 sFv was a potent CD40 agonist that rapidly crosslinked CD40 on the cell surface but did not crosslink CD40-Ig in solution.
J A, Ledbetter +14 more
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A single-chain Fv (sFv) was expressed from the variable regions of the CD40-specific mAb G28-5. The molecule bound CD40 with a high affinity (2.2 nM) and was a monomer in solution. Surprisingly, G28-5 sFv was a potent CD40 agonist that rapidly crosslinked CD40 on the cell surface but did not crosslink CD40-Ig in solution.
J A, Ledbetter +14 more
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Eine saluretische Wirkungskomponente des Uricosuricums G28 315 (Anturan®)
Pharmacology, 1959openaire +2 more sources

