The Apparent Requirement for Protein Synthesis during G2 Phase Is due to Checkpoint Activation [PDF]
Cell Reports, 2020 Summary: Protein synthesis inhibitors (e.g., cycloheximide) block mitotic entry, suggesting that cell cycle progression requires protein synthesis until right before mitosis.
Sarah Lockhead +7 more
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Parvovirus B19 NS1 protein induces cell cycle arrest at G2-phase by activating the ATR-CDC25C-CDK1 pathway. [PDF]
PLoS Pathogens, 2017 Human parvovirus B19 (B19V) infection of primary human erythroid progenitor cells (EPCs) arrests infected cells at both late S-phase and G2-phase, which contain 4N DNA.
Peng Xu +11 more
doaj +3 more sources
Pathways for Genome Integrity in G2 Phase of the Cell Cycle [PDF]
Biomolecules, 2012 The maintenance of genome integrity is important for normal cellular functions, organism development and the prevention of diseases, such as cancer. Cellular pathways respond immediately to DNA breaks leading to the initiation of a multi-facetted DNA ...
Claus Storgaard Sørensen +2 more
doaj +5 more sources
Loss of CDK4/6 activity in S/G2 phase leads to cell cycle reversal. [PDF]
Nature, 2023 We uncover the mechanism underlying the restriction point phenomenon, suggest a role for cyclin-dependent kinase 4 and 6 activity in S and G2 phases, and explain the behaviour of cells following loss of mitogen signalling.
Cornwell JA +5 more
europepmc +2 more sources
Negative Regulation of G2 Phase [PDF]
Definitions, 2020 G2 Phase Arrest consists of interference with, or restraint of, activities that regulate the cellular capacity to transit the cell cycle phase preceding mitosis (Gap 2 phase). The chromosomes are tetraploid in this phase.
semanticscholar +2 more sources
FGF19 induces the cell cycle arrest at G2-phase in chondrocytes. [PDF]
Cell Death Discov, 2023 AbstractFibroblast growth factor 19 (FGF19) has appeared as a new possible avenue in the treatment of skeletal metabolic disorders. However, the role of FGF19 on cell cycle progression in skeletal system is poorly understood. Here we demonstrated that FGF19 had the ability to reduce the proliferation of chondrocytes and cause cell cycle G2 phase arrest
Chen H +6 more
europepmc +4 more sources
Cohesin-mediated DNA loop extrusion resolves sister chromatids in G2 phase. [PDF]
EMBO J, 2023 Abstract Genetic information is stored in linear DNA molecules, which are highly folded inside cells. DNA replication along the folded template path yields two sister chromatids that initially occupy the same nuclear region in an intertwined arrangement.
Batty P +6 more
europepmc +4 more sources
Cyclin F-dependent degradation of E2F7 is critical for DNA repair and G2-phase progression. [PDF]
EMBO J, 2019 E2F7 and E2F8 act as tumor suppressors via transcriptional repression of genes involved in S‐phase entry and progression. Previously, we demonstrated that these atypical E2Fs are degraded by APC/CCdh1 during G1 phase of the cell cycle.
Yuan R +7 more
europepmc +2 more sources
Quercetin induces G2 phase arrest and apoptosis with the activation of p53 in an E6 expression‑independent manner in HPV‑positive human cervical cancer‑derived cells. [PDF]
Mol Med Rep, 2019 Cervical cancer is the second most common cancer in women worldwide. Human papillomavirus (HPV) infection appears to be a necessary factor in the development of almost all cases (>95%) of cervical cancer.
Clemente-Soto AF +5 more
europepmc +2 more sources
Apigenin impedes cell cycle progression at G2 phase in prostate cancer cells [PDF]
Discover Oncology, 2022 As a natural flavone, apigenin is abundantly present in vegetables, fruits, oregano, tea, chamomile, wheat sprout and is regarded as a major component of the Mediterranean diet. Apigenin is known to inhibit proliferation in different cancer cell lines by
Su Su Thae Hnit +8 more
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