Results 151 to 160 of about 7,092,513 (195)

Downregulation of Cyclin B1 mediates nagilactone E‐induced G2 phase cell cycle arrest in non‐small cell lung cancer cells

European Journal of Pharmacology, 2018
Non‐small cell lung cancer (NSCLC) is one of the most common forms and leading causes of cancer‐related mortality worldwide, and discovery of new effective drugs still remains imperative to improve the survival rate.
Le-le Zhang, Zhe-ling Feng, Min-xia Su, Xiao-ming Jiang, Xiuping Chen, Yitao Wang, Ao Li, Ligen Lin, Jin-jian Lu   +8 more
semanticscholar   +1 more source

Wnt Signaling Couples G2 Phase Control with Differentiation During Hematopoiesis

2023
SummaryDuring homeostasis, a critical balance is maintained between myeloid-like progenitors and their differentiated progeny, which function to mitigate stress and innate immune challenges. The molecular mechanisms that help achieve this balance are not fully understood. Using genetic dissection inDrosophila, we show that a Wnt6/EGFR-signaling network
Lauren M. Goins, Juliet R. Girard, Bama Charan Mondal, Sausan Buran, Chloe C. Su, Ruby Tang, Titash Biswas, Utpal Banerjee   +7 more
openaire   +1 more source

Gas-phase acidities: a comparison of density functional, MP2, MP4, F4, G2(MP2, SVP), G2(MP2) and G2 procedures

Chemical Physics Letters, 1995
Abstract A comparison of several methods for calculating gas-phase acidities is reported. Methods examined include density functional theory with the B-LYP, B-P86, B3-LYP and B3-P86 non-local functionals, second-order [MP2] and fourth-order [MP4] Moller-Plesset and fourth-order Feenberg [F4] theories, quadratic configuration interaction (QCISD(T ...
Brian J. Smith, Leo Radom
openaire   +1 more source

Prolonged G2 phase of breast cancer cells and chromosome damage

European Journal of Cancer and Clinical Oncology, 1991
5-bromodeoxyuridine incorporation was studied in metaphase chromosomes from 24 breast tumour specimens, including 23 adenocarcinomas. In these 23 cases, a slow cell cycle was observed, with a long (8 h) G2 phase. This slowing of the cell cycle, which was poorly related to the degree of polyploidy, was significantly related to the number of chromosome ...
B, Dutrillaux, M, Gerbault-Seureau, B, Zafrani, M, Prieur   +3 more
openaire   +2 more sources

Resveratrol Arrests the Cell Division Cycle at S/G2 Phase Transition

Biochemical and Biophysical Research Communications, 1998
Resveratrol (3,5,4'-trihydroxystilbene) is a naturally occurring phytoalexin, found in grapes and wine, which has been reported to exert a variety of important pharmacological effects. We have investigated the activity of resveratrol on proliferation and differentiation of the promyelocitic cell line HL-60.
DELLA RAGIONE, Fulvio, CUCCIOLLA V., BORRIELLO, Adriana, DELLA PIETRA V., RACIOPPI L., SOLDATI G., MANNA, Caterina, GALLETTI P., ZAPPIA V.   +8 more
openaire   +4 more sources

Interference with S and G2 phase progression by polyamine synthesis inhibitors

Experimental Cell Research, 1978
Abstract The distribution of Ehrlich ascites tumor cells in the cell cycle was studied by flow cytometry following treatment with α-methyl ornithine (αMO) or methylglyoxal- bis (guanylhydrazone) (MeGAG). αMO and MeGAG are potent inhibitors of ornithine decarboxylase (putrescine synthesis) and S-adenosyl-methionine decarboxylase (spermidine and ...
O, Heby, G, Andersson, J W, Gray
openaire   +2 more sources

Radiation sensitivity of bloom's syndrome lymphocytes during S and G2 phases

Cancer Genetics and Cytogenetics, 1985
In order to study chromosome sensitivity of Bloom's syndrome (BS) cells in relation to the replication stage, gamma-ray irradiation was performed immediately before adding bromodeoxyuridine (BrdU) to lymphocyte cultures of one BS patient and of one control.
A, Aurias, J L, Antoine, R, Assathiany, M, Odievre, B, Dutrillaux   +4 more
openaire   +2 more sources

Specific G2 phase toxicity of chloramphenicol on mouse leukemic cells (L5178Y)

Experimental Cell Research, 1973
Abstract The effect of chloramphenicol on progression through the cell cycle of L5178Y cells was investigated. Using eosin staining as a viability index, G2 cells were shown to be specifically killed at a concentration of chloramphenicol generally used to study mitochondrial protein synthesis. Pretreating cells with chloramphenicol induced resistance
Liberman, D F, Roti, J L, Lange, C S
openaire   +2 more sources

Phase diagram and dilution experiments in the crystallization of carboxypeptidase G2

Acta Crystallographica Section D Biological Crystallography, 1994
The automated microbatch technique developed at Imperial College has been used to establish a phase diagram for crystallization. The concentrations of the protein (carboxypeptidase G2) and precipitant (PEG 4000) were varied, while pH and temperature were kept constant.
E E, Saridakis, P D, Stewart, L F, Lloyd, D M, Blow   +3 more
openaire   +2 more sources

Trichomonas vaginalis: Dominant G2 Period and G2 Phase Arrest in a Representative of an Early Branching Eukaryotic Lineage

Journal of Eukaryotic Microbiology, 1994
ABSTRACT. Eukaryotic mitotic cell cycles have been extensively studied in yeasts and vertebrate cells but little is known about cell cycle mechanisms in early branches of the eukaryotic lineage. Trichomonas vaginalis represents one of the earliest branching eukaryotic lineages available for study. In contrast with most yeasts and vertebrate cells, the
D E, Riley, J N, Krieger, D, Miner, P S, Rabinovitch   +3 more
openaire   +2 more sources