Results 21 to 30 of about 7,092,513 (195)
Two pathways recruit telomerase to Saccharomyces cerevisiae telomeres. [PDF]
PLoS Genetics, 2008 The catalytic subunit of yeast telomerase, Est2p, is a telomere associated throughout most of the cell cycle, while the Est1p subunit binds only in late S/G2 phase, the time of telomerase action.
Angela Chan +2 more
doaj +1 more source
G2 phase chromatin lacks determinants of replication timing [PDF]
Journal of Cell Biology, 2010 DNA replication in all eukaryotes follows a defined replication timing program, the molecular mechanism of which remains elusive. Using a Xenopus laevis egg extract replication system, we previously demonstrated that replication timing is established during early G1 phase of the cell cycle (timing decision point [TDP]), which is coincident with the ...
Lu, Junjie +4 more
openaire +2 more sources
A G2-Phase Microtubule-Damage Response in Fission Yeast [PDF]
Genetics, 2008 AbstractMicrotubules assume a variety of structures throughout the different stages of the cell cycle. Ensuring the correct assembly of such structures is essential to guarantee cell division. During mitosis, it is well established that the spindle assembly checkpoint monitors the correct attachment of sister chromatids to the mitotic spindle. However,
Balestra, F. R. +1 more
openaire +3 more sources
Inhibition of S/G2 phase CDK4 reduces mitotic fidelity [PDF]
Melanoma Research, 2006 Cyclin-dependent kinase 4 (CDK4)/cyclin D has a key role in regulating progression through late G(1) into S phase of the cell cycle. CDK4-cyclin D complexes then persist through the latter phases of the cell cycle, although little is known about their potential roles.
Burgess, A +6 more
openaire +4 more sources
Acta Biochimica et Biophysica Sinica, 2022 The presence of senescent cells is associated with renal fibrosis. This study aims to investigate the effect of albumin-induced premature senescence on tubulointerstitial fibrosis and its possible mechanism in vitro.
Lu Wen +6 more
doaj +1 more source
G2 phase-specific proteins of HeLa cells. [PDF]
Proceedings of the National Academy of Sciences, 1978 The objective of this study was to determine if HeLa cells irreversibly arrested in G2 phase of the cell cycle by a brief exposure to a nitrosourea compound were deficient in certain proteins when compared with G2-synchronized cells. Total cellular proteins of G2-synchronized, G2-arrested, and S phase-synchronized cells were compared by two-dimensional
A A, Al-Bader, A, Orengo, P N, Rao
openaire +2 more sources
c-Myb regulates cell cycle-dependent expression of Erbin: an implication for a novel function of Erbin. [PDF]
PLoS ONE, 2012 In the present study, we demonstrated the cell cycle periodicity of Erbin expression with the maximal expression of Erbin in G2/M phase. A significant increase in Erbin promoter activity was observed in G2/M phase-synchronized cells.
Dan Liu +10 more
doaj +1 more source
A novel single virus infection system reveals that influenza virus preferentially infects cells in g1 phase. [PDF]
PLoS ONE, 2013 BackgroundInfluenza virus attaches to sialic acid residues on the surface of host cells via the hemagglutinin (HA), a glycoprotein expressed on the viral envelope, and enters into the cytoplasm by receptor-mediated endocytosis.
Ryuta Ueda +12 more
doaj +1 more source
Partial inhibition of Cdk1 in G2 phase overrides the SAC and decouples mitotic events
Cell Cycle, 2014 Entry and progression through mitosis has traditionally been linked directly to the activity of cyclin-dependent kinase 1 (Cdk1). In this study we utilized low doses of the Cdk1-specific inhibitor, RO3306 from early G2 phase onwards.
R. McCloy +5 more
semanticscholar +1 more source
A Cyclin D-Cdk4 Activity Required for G2 Phase Cell Cycle Progression Is Inhibited in Ultraviolet Radiation-induced G2 Phase Delay [PDF]
Journal of Biological Chemistry, 1999 Cyclin D-Cdk4 complexes have a demonstrated role in G1 phase, regulating the function of the retinoblastoma susceptibility gene product (Rb). Previously, we have shown that following treatment with low doses of UV radiation, cell lines that express wild-type p16 and Cdk4 responded with a G2 phase cell cycle delay.
Gabrielli, B. +6 more
openaire +3 more sources