Results 31 to 40 of about 7,092,513 (195)
Frontiers in Cell and Developmental Biology, 2020 Cubic membranes (CMs) represent unique biological membrane structures with highly curved three-dimensional periodic minimal surfaces, which have been observed in a wide range of cell types and organelles under various stress conditions (e. g., starvation,
Deqin Kong +8 more
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The Cell Cycle Timing of Human Papillomavirus DNA Replication. [PDF]
PLoS ONE, 2015 Viruses manipulate the cell cycle of the host cell to optimize conditions for more efficient viral genome replication. One strategy utilized by DNA viruses is to replicate their genomes non-concurrently with the host genome; in this case, the viral ...
Tormi Reinson +4 more
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NQO1 regulates cell cycle progression at the G2/M phase
Theranostics, 2023 Rationale: Overexpression of NAD(P)H:quinone oxidoreductase 1 (NQO1) is associated with tumor cell proliferation and growth in several human cancer types. However, the molecular mechanisms underlying the activity of NQO1 in cell cycle progression are currently unclear.
Oh, Eun-Taex +7 more
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Insects, 2021 Understanding virus–host interaction is very important for delineating the mechanism involved in viral replication and host resistance. Baculovirus, an insect virus, can cause S or G2/M phase arrest in insect cells.
Qin Xiao +8 more
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Scientific Reports, 2019 Using data generated with cells exposed to ionizing-radiation (IR) in G2-phase of the cell cycle, we describe dose-dependent interactions between ATM, ATR and DNA-PKcs revealing unknown mechanistic underpinnings for two key facets of the DNA damage ...
E. Mladenov +4 more
semanticscholar +1 more source
CDK1 inhibitor controls G2/M phase transition and reverses DNA damage sensitivity.
Biochemical and Biophysical Research Communications - BBRC, 2021 CDK1 plays key roles in cell cycle progression through the G2/M phase transition and activation of homologous recombination (HR) DNA repair pathway. Accordingly, various CDK1 inhibitors have been developed for cancer therapy that induce prolonged G2 ...
Shigeaki Sunada +4 more
semanticscholar +1 more source
Cell cycle G2/M arrest through an S phase-dependent mechanism by HIV-1 viral protein R
Retrovirology, 2010 Background Cell cycle G2 arrest induced by HIV-1 Vpr is thought to benefit viral proliferation by providing an optimized cellular environment for viral replication and by skipping host immune responses.
Liang Dong +3 more
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Cells, 2020 Cells recovering from the G2/M DNA damage checkpoint rely more on Aurora A-PLK1 signaling than cells progressing through an unperturbed G2 phase, but the reason for this discrepancy is not known.
Lorenzo Lafranchi +3 more
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S-phase, G2, and nuclear division mutants of Aspergillus nidulans [PDF]
Journal of Bacteriology, 1984 Twenty-two temperature-sensitive cell cycle mutants of the fungus Aspergillus nidulans, which block in interphase at restrictive temperature, were analyzed by the reciprocal shift method of Jarvik and Botstein (Proc. Nath Acad. Sci. U.S.A. 70:2046-2050, 1973) and Hereford and Hartwell (J. Mol. Biol.
L G, Bergen, A, Upshall, N R, Morris
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Re-investigating PLK1 inhibitors as antimitotic agents
Molecular & Cellular Oncology, 2017 Polo-like kinase 1 (PLK1) plays key roles during mitosis, prompting the development of PLK1 inhibitors for anticancer therapy. We recently determined that PLK1 is crucially required for entry into mitosis.
Quentin Delacour, Olivier Gavet
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