Results 41 to 50 of about 7,092,513 (195)
Cell Cycle Regulation by Integrin-Mediated Adhesion
Cells, 2022 Cell cycle and cell adhesion are two interdependent cellular processes regulating each other, reciprocally, in every cell cycle phase. The cell adhesion to the extracellular matrix (ECM) via integrin receptors triggers signaling pathways required for the
Siamak A. Kamranvar +2 more
doaj +1 more source
Cell Discovery, 2017 Aurora-A kinase functions mainly in centrosome maturation, separation and spindle formation. It has also been found to be amplified or overexpressed in a range of solid tumors, which is linked with tumor progression and poor prognosis.
Fazhi Yu +11 more
semanticscholar +1 more source
Post-transcriptional regulation of cyclin D1 expression during G2 phase [PDF]
Oncogene, 2002 During continuous proliferation, cyclin D1 protein is induced to high levels in a Ras-dependent manner as cells progress from S phase to G2 phase. To understand the mechanism of the Ras-dependent cyclin D1 induction, cyclin D1 mRNA levels were determined by quantitative image analysis following fluorescent in situ hybridization.
Yang, Guo +2 more
openaire +2 more sources
Cyclizing-berberine A35 induces G2/M arrest and apoptosis by activating YAP phosphorylation (Ser127)
Journal of Experimental & Clinical Cancer Research, 2018 Background A35 is a novel synthetic cyclizing-berberine recently patented as an antitumor compound. Based on its dual targeting topoisomerase (top) activity, A35 might overcome the resistance of single-target top inhibitors and has no cardiac toxicity ...
Wuli Zhao +4 more
doaj +1 more source
p53-dependent polyploidisation after DNA damage in G2 phase [PDF]
, 2020 AbstractCell cycle progression in the presence of damaged DNA can lead to accumulation of mutations and pose a risk for tumour development. In response to DNA damage in G2 phase, human cells can be forced to exit the cell cycle in a p53-p21- and APC/CCdh1-dependent manner.
Anna Middleton +4 more
openaire +1 more source
Cell-Cycle-Dependent Regulation of Ca2+-Activated K+ Channel in Jurkat T-Lymphocyte
Journal of Pharmacological Sciences, 2007 Small-conductance Ca2+-activated K+ (SK2) channel plays an important role in the activation of Jurkat T-lymphocytes by maintaining electrical gradients for the sustained Ca2+ influx. Apamin-sensitive K+ current was significantly decreased with cell-cycle
Takashi Morimoto +4 more
doaj +1 more source
OncoTarget, 2015 Ribosome biogenesis is a fundamental cellular process and is elevated in cancer cells. As one of the most energy consuming cellular processes, it is highly regulated by signaling pathways in response to changing cellular conditions.
Sandeep S. Negi, P. Brown
semanticscholar +1 more source
Gene expression profiling of HeLa cells in G1 or G2 phases [PDF]
Oncogene, 2002 The cell division cycle is regulated through both transcriptional and post-transcriptional mechanisms. The altered expression of a number of genes at the mRNA level is known to be essential for progression through the cell cycle, however, a comprehensive gene expression profile of human cells remains to be completed.
Chaudhry, M +3 more
openaire +2 more sources
Effect of X-Irradiation at Different Stages in the Cell Cycle on Individual Cell-Based Kinetics in an Asynchronous Cell Population. [PDF]
PLoS ONE, 2015 Using an asynchronously growing cell population, we investigated how X-irradiation at different stages of the cell cycle influences individual cell-based kinetics.
Eri Tsuchida +6 more
doaj +1 more source
Huntingtin-Interacting Protein 1 Promotes Vpr-Induced G2 Arrest and HIV-1 Infection in Macrophages
Viruses, 2021 Human immunodeficiency virus type 1 (HIV-1) modulates the host cell cycle. The HIV-1 accessory protein Vpr arrests the cell cycle at the G2 phase in dividing cells, and the ability of Vpr to induce G2 arrest is well conserved among primate lentiviruses ...
Tomoyuki Murakami +4 more
doaj +1 more source