Results 61 to 70 of about 7,092,513 (195)
Aurora A polyubiquitinates the BRCA1-interacting protein OLA1 to promote centrosome maturation
Cell Reports, 2023 Summary: The BRCA1-interacting protein Obg-like ATPase 1 (OLA1) functions in centriole duplication. In this study, we show the role of the mitotic kinase Aurora A in the reduction of centrosomal OLA1.
Zhenzhou Fang +13 more
doaj +1 more source
BAC-G2 Predictions of Thermochemistry for Gas-Phase Aluminum Compounds [PDF]
The Journal of Physical Chemistry A, 2001 A self-consistent set of thermochemical data for 55 molecules in the Al-H-C-O-F-Cl system are obtained from ab initio quantum-chemistry calculations using the BAC-G2 method. Calculations were performed for both stable and radical species. Good agreement is found between the calculations and experimental heats of formation in most cases where data are ...
Mark D. Allendorf +3 more
openaire +3 more sources
Journal of Integrative Agriculture, 2014 Isolated ruminal epithelia from caudal blind sacs of dairy goats were incubated with butyrate and insulin-like growth factor-1 (IGF-1) at different concentrations.
Da-cheng LIU +4 more
doaj +1 more source
Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling
Cells, 2021 The cell cycle is the series of events that take place in a cell, which drives it to divide and produce two new daughter cells. The typical cell cycle in eukaryotes is composed of the following phases: G1, S, G2, and M phase.
Zhixiang Wang
doaj +1 more source
Preparation for mitosis requires gradual CDK1 activation
iScienceSummary: G2 phase is considered as a time in which cells prepare for the large structural changes in the following mitosis. Starting at completion of DNA replication, CDK1 and PLK1 kinase activities gradually increase throughout G2 phase until reaching ...
Karen Akopyan, Zhiyu Hao, Arne Lindqvist
doaj +1 more source
Cdk activity drives senescence from G2 phase
, 2016 AbstractIn response to DNA damage a cell can be forced to permanently exit the cell cycle and become senescent. Senescence provides an early barrier against tumor development by preventing proliferation of cells with damaged DNA. By studying single cells, we show that Cdk activity is retained after DNA damage until terminal cell cycle exit.
Müllers, Erik +3 more
openaire +1 more source
MOF Phosphorylation by ATM Regulates 53BP1-Mediated Double-Strand Break Repair Pathway Choice
Cell Reports, 2014 Cell-cycle phase is a critical determinant of the choice between DNA damage repair by nonhomologous end-joining (NHEJ) or homologous recombination (HR).
Arun Gupta +15 more
doaj +1 more source
Staphylococcus aureus-induced G2/M phase transition delay in host epithelial cells increases bacterial infective efficiency. [PDF]
PLoS ONE, 2013 Staphylococcus aureus is a highly versatile, opportunistic pathogen and the etiological agent of a wide range of infections in humans and warm-blooded animals. The epithelial surface is its principal site of colonization and infection.
Ludmila Alekseeva +11 more
doaj +1 more source
Elevated radiation-induced γH2AX foci in G2 phase heterozygous BRCA2 fibroblasts
Radiotherapy and Oncology, 2011 About 5-10% of all breast cancer cases are associated with heterozygous germ-line mutations in the genes encoding BRCA1 and BRCA2. Carriers of such mutations are highly predisposed for developing breast or ovarian cancer and, thus, are advised to undergo regular radio-diagnostic examinations.
Beucher, Andrea +5 more
openaire +3 more sources
E2F activity determines mitosis versus whole-genome duplication in G2-arrested cells
Nature CommunicationsWhile mitogenic signaling is known to regulate cell-cycle entry during the G1 phase, its function in the G2 phase remains elusive. Here we show that mitogenic signaling controls whether G2-arrested cells proceed through mitosis or undergo whole-genome ...
Kibum Kim +3 more
doaj +1 more source