Results 71 to 80 of about 7,092,513 (195)

Novel phase I study combining G1 phase, S phase, and G2/M phase cell cycle inhibitors in patients with advanced malignancies [PDF]

Cell Cycle, 2015
ABSTRACTPURPOSE: Cancer is a manifestation of aberrant cellular proliferation, and the cell cycle is one of the most successfully drugged targets in oncology. No prior study has been reported that simultaneously targets the three principal cell cycle phases populated by proliferating cells - G1, S, and G2/M.METHODS: Temsirolimus (G1 inhibitor ...
Rajul K, Jain, David S, Hong, Aung, Naing, Jennifer, Wheler, Thorunn, Helgason, Nai-Yi, Shi, Yash, Gad, Razelle, Kurzrock   +7 more
openaire   +2 more sources

Gatifloxacin Induces S and G2-Phase Cell Cycle Arrest in Pancreatic Cancer Cells via p21/p27/p53

PLoS ONE, 2012
Pancreatic cancer, despite being the most dreadful among gastrointestinal cancers, is poorly diagnosed, and further, the situation has been aggravated owing to acquired drug resistance against the single known drug therapy.
V. Yadav, S. Sultana, J. Yadav, Neeru Saini   +3 more
semanticscholar   +1 more source

RPA Accumulation during Class Switch Recombination Represents 5′–3′ DNA-End Resection during the S–G2/M Phase of the Cell Cycle

Cell Reports, 2013
Activation-induced cytidine deaminase (AID) promotes chromosomal translocations by inducing DNA double-strand breaks (DSBs) at immunoglobulin (Ig) genes and oncogenes in the G1 phase.
Arito Yamane, Davide F. Robbiani, Wolfgang Resch, Anne Bothmer, Hirotaka Nakahashi, Thiago Oliveira, Philipp C. Rommel, Eric J. Brown, Andre Nussenzweig, Michel C. Nussenzweig, Rafael Casellas   +10 more
doaj   +1 more source

Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway

Acta Pharmaceutica Sinica B, 2021
Glioblastoma multiforme (GBM) in the central nervous system is the most lethal advanced glioma and currently there is no effective treatment for it. Studies of sinomenine, an alkaloid from the Chinese medicinal plant, Sinomenium acutum, showed that it ...
Xiangjin Zheng, Wan Li, Huanli Xu, Jinyi Liu, Liwen Ren, Yihui Yang, Sha Li, Jinhua Wang, Tengfei Ji, Guanhua Du   +9 more
doaj   +1 more source

Heterogeneity of planarian stem cells in the S/G2/M phase

The International Journal of Developmental Biology, 2012
The planarian adult stem cell (pASC) population has a specific molecular signature and can be easily visualized and isolated by flow cytometry. However, the lack of antibodies against specific surface markers for planarian cells prevents a deeper analysis of specific cell populations.
Sören, Moritz, Franziska, Stöckle, Claudia, Ortmeier, Henning, Schmitz, Gustavo, Rodríguez-Esteban, Göran, Key, Luca, Gentile   +6 more
openaire   +3 more sources

Sodium Fluoride Arrests Renal G2/M Phase Cell-Cycle Progression by Activating ATM-Chk2-P53/Cdc25C Signaling Pathway in Mice

Cellular Physiology and Biochemistry, 2018
Background/Aims: Excessive fluoride intake can induce cytotoxicity, DNA damage and cell-cycle changes in many tissues and organs, including the kidney. However, the underlying molecular mechanisms of fluoride-induced renal cell-cycle changes are not well
Qin Luo, Hongrui Guo, Ping Kuang, Hengmin Cui, Huidan Deng, Huan Liu, Yujiao Lu, Qin Wei, Linlin Chen, Jing Fang, Zhicai Zuo, Junliang Deng, Yinglun Li, Xun Wang, Ling Zhao   +14 more
doaj   +1 more source

ER Stress Induces Cell Cycle Arrest at the G2/M Phase Through eIF2α Phosphorylation and GADD45α

International Journal of Molecular Sciences, 2019
Endoplasmic reticulum (ER) stress is known to influence various cellular functions, including cell cycle progression. Although it is well known how ER stress inhibits cell cycle progression at the G1 phase, the molecular mechanism underlying how ER ...
Duckgue Lee, Daniel Hokinson, Soyoung Park, Rosalie Elvira, Fedho Kusuma, Ji-Min Lee, Miyong Yun, Seok-Geun Lee, Jaeseok Han   +8 more
semanticscholar   +1 more source

Role of gamma-giardin in ventral disc formation of Giardia lamblia

Parasites & Vectors, 2019
Background Giardia lamblia, a protozoan pathogen causing diarrheal outbreaks, has characteristic cytoskeletal structures including eight flagella, a median body and a ventral disc.
Juri Kim, Soon-Jung Park
doaj   +1 more source

Coxsackievirus A6 Induces Cell Cycle Arrest in G0/G1 Phase for Viral Production

Frontiers in Cellular and Infection Microbiology, 2018
Recent epidemiological data indicate that outbreaks of hand, foot, and mouth disease (HFMD), which can be categorized according to its clinical symptoms as typical or atypical, have markedly increased worldwide. A primary causative agent for typical HFMD
Zengyan Wang, Yue Wang, Shaohua Wang, Xiangling Meng, Fengmei Song, Wenbo Huo, Shuxia Zhang, Junliang Chang, Jingliang Li, Baisong Zheng, Yanqiu Liu, Yahong Zhang, Wenyan Zhang, Jinghua Yu   +13 more
doaj   +1 more source

The topoisomerase II inhibitor VM-26 induces marked changes in histone H1 kinase activity, histones H1 and H3 phosphorylation, and chromosome condensation in G2 phase and mitotic BHK cells

Journal of Cell Biology, 1990
We have examined the effects of topoisomerase inhibitors on the phosphorylation of histones in chromatin during the G2 and the M phases of the cell cycle.
Michel Roberge, John Th 'ng, Joyce R. Hamaguchi, E. Morton Bradbury   +3 more
semanticscholar   +1 more source