Results 101 to 110 of about 7,778 (203)

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Prevalence of G6PD deficiency and molecular characterization of G202A, A376G and C563T polymorphisms in newborns in Southeastern Brazil

Einstein (São Paulo)
Objective To evaluate the prevalence of G6PD deficiency and characterize G202A, A376G and C563T polymorphisms in neonates using molecular assays. Methods A total of one thousand samples were tested through quantitative analysis of enzyme activity ...
Lucas Luís Meigre Dias Pereira, Cristina Augusta Bravin, Terezinha Sarquis Cintra, Wélida Santos Portela Cassa, Thainá Altoé Santos, Armando Fonseca, Rodrigo Pratte-Santos   +6 more
doaj   +1 more source

Dynamics of G6PD activity in patients receiving weekly primaquine for therapy of Plasmodium vivax malaria.

PLoS Neglected Tropical Diseases, 2021
BackgroundAcute Plasmodium vivax malaria is associated with haemolysis, bone marrow suppression, reticulocytopenia, and post-treatment reticulocytosis leading to haemoglobin recovery. Little is known how malaria affects glucose-6-phosphate dehydrogenase (
Walter R J Taylor, Saorin Kim, Sim Kheng, Sinoun Muth, Pety Tor, Eva Christophel, Mavuto Mukaka, Alexandra Kerleguer, Lucio Luzzatto, J Kevin Baird, Didier Menard   +10 more
doaj   +1 more source

Analytical Validation of an Annotation Tool for WGS‐Based Pharmacogenomics: Preparing for Clinical Implementation in Pediatric Oncology

Clinical and Translational Science, Volume 19, Issue 4, April 2026.
Selection and validation of a whole genome sequencing pharmacogenomics annotation tool. ABSTRACT Whole genome sequencing (WGS) is increasingly accessible in clinical practice, enabling pharmacogenomics (PGx) integration, including in pediatric oncology.
Meta H. M. Diekstra, Nienke Biesot, Julie Donders, Eugène T. P. Verwiel, Alex Janse, Alwin D. R. Huitema, Lidwien M. Hanff, Bastiaan B. J. Tops, Patrick Kemmeren, Jayne Y. Hehir‐Kwa   +9 more
wiley   +1 more source

Genetic spectrum and clinical early natural history of glucose-6-phosphate dehydrogenase deficiency in Mexican children detected through newborn screening

Orphanet Journal of Rare Diseases, 2021
Background Glucose-6-phosphate dehydrogenase deficiency (G6PDd) newborn screening is still a matter of debate due to its highly heterogeneous birth prevalence and clinical expression, as well as, the lack of enough knowledge on its natural history ...
Marcela Vela-Amieva, Miguel Angel Alcántara-Ortigoza, Ariadna González-del Angel, Leticia Belmont-Martínez, Carlos López-Candiani, Isabel Ibarra-González   +5 more
doaj   +1 more source

Molecular Testing in Sickle Cell Disease: From Newborn Screening to Transfusion Care

International Journal of Laboratory Hematology, Volume 48, Issue 2, Page 295-304, April 2026.
ABSTRACT Sickle cell disease (SCD) is one of the most frequent monogenic diseases worldwide and a highly heterogeneous and complex disease. SCD care carries several challenges. This includes early and accurate diagnosis as well as optimal red blood cell transfusion matching in this population carrying a high risk of alloimmunization.
Thomas Pincez, Yves D. Pastore
wiley   +1 more source

Evaluation of the Diagnostic Accuracy of the Quantitative Point‐of‐Care SD Biosensor Standard G6PD Test for Assessment of G6PD Deficiency in Infectious Diseases

International Journal of Laboratory Hematology, Volume 48, Issue 2, Page 440-446, April 2026.
ABSTRACT Background G6PD deficiency affects about 500 million people worldwide and is prevalent in many malaria‐endemic settings. People with G6PD deficiency are at risk of hemolysis when exposed to certain medications, including 8‐aminoquinoline drugs used to treat Plasmodium vivax malaria.
Flavia Regina Medeiros da Silva, Alexandre Gomes Vizzoni, Daniela Mendes‐de‐Almeida, Joanna Bokel, Raquel de Vasconcellos Carvalhaes de Oliveira, André Machado Siqueira, Yasmine Rangel Vieira, Simone da Costa Cruz Silva   +7 more
wiley   +1 more source

Distribution of msp1, msp2 and eba175 Allelic Family According to Hemoglobin Genotype and G6PD Type from Children with Uncomplicated Malaria in Banfora Heath District (Burkina Faso)

Journal of Scientific Research and Reports, 2020
Aim: The present study aimed to evaluate the Plasmodium falciparum genetic diversity according to the host hemoglobin and G6PD genetic variants during the course of malaria in infected children aged from 2 to 10 years and living in endemic area in Burkina Faso. Study Design: The study was designed as a longitudinal follow up conducted between May
Issiaka Soulama, Youssef Idaghdour, Sodiomon Bienvenu Sirima, Alfred B. Tiono, Alfred Sababeni Traoré, Désiré Kargougou, Aissata Barry, Wael Said Abdrabou, Noelie Henry/Béré, Sam Aboubacar Coulibaly, Emilie S. Badoum, Amidou Diarra, Mame Massar Dieng, Aïssatou Diawara, Samuel Sindié Sermé, Salif Sombié   +15 more
openaire   +2 more sources

Evaluating the relationship between Clinical G6PD enzyme activity and gene variants [PDF]

PeerJ
Glucose-6-phosphate dehydrogenase (G6PD) is a the first and rate-limiting enzyme that plays a critical role in G6PD deficiency, the most common enzyme disorder worldwide, is related to intravascular hemolysis.
Xinyi Zhou, Zheng Qiang, Sufen Zhang, Yuqiu Zhou, Qizhi Xiao, Gongjun Tan   +5 more
doaj   +2 more sources

Fundamentals of big data and artificial intelligence in transfusion medicine

Vox Sanguinis, Volume 121, Issue 4, Page 430-440, April 2026.
Abstract Within the digital transformation of medicine, transfusion medicine has quietly become a big‐data discipline. The long‐standing tradition of blood product standardization (e.g., ISBT‐128) and large donor cohorts being followed over years—some of which are sampled in national biobank projects, build a favourable setting.
Amin T. Turki, Christian Martin Brieske, Umut A. Gurkan, Katja M. Scheidler, O. Berk Usta, Esa Turkulainen, Kamyar Arzideh, Christian Temme, René Hosch, Peter A. Horn, Mikko Arvas   +10 more
wiley   +1 more source