Results 31 to 40 of about 7,778 (203)

Performance of the CareStart™ G6PD deficiency screening test, a point-of-care diagnostic for primaquine therapy screening. [PDF]

PLoS ONE, 2011
Development of reliable, easy-to-use, rapid diagnostic tests (RDTs) to detect glucose-6-phosphate dehydrogenase (G6PD) deficiency at point of care is essential to deploying primaquine therapies as part of malaria elimination strategies. We assessed a kit
Saorin Kim, Chea Nguon, Bertrand Guillard, Socheat Duong, Sophy Chy, Sarorn Sum, Sina Nhem, Christiane Bouchier, Magali Tichit, Eva Christophel, Walter R J Taylor, John Kevin Baird, Didier Menard   +12 more
doaj   +1 more source

Molecular characterization of G6PD mutations reveals the high frequency of G6PD Aures in the Lao Theung population

Malaria Journal, 2021
Background The prevalence and genotypes of G6PD deficiency vary worldwide, with higher prevalence in malaria endemic areas. The first-time assessment of G6PD deficiency prevalence and molecular characterization of G6PD mutations in the Lao Theung ...
Amkha Sanephonasa, Chalisa Louicharoen Cheepsunthorn, Naly Khaminsou, Onekham Savongsy, Issarang Nuchprayoon, Kamonlak Leecharoenkiat   +5 more
doaj   +1 more source

Genotypes and phenotypes of G6PD deficiency among Indonesian females across diagnostic thresholds of G6PD activity guiding safe primaquine therapy of latent malaria

PLOS Neglected Tropical Diseases, 2021
Background Plasmodium vivax occurs as a latent infection of liver and a patent infection of red blood cells. Radical cure requires both blood schizontocidal and hypnozoitocidal chemotherapies. The hypnozoitocidal therapies available are primaquine and tafenoquine, 8-aminoquinoline drugs that can provoke threatening acute hemolytic anemia in patients ...
Satyagraha, AW, Sadhewa, A, Panggalo, LV, Subekti, D, Elyazar, I, Soebianto, S, Mahpud, N, Harahap, AR, Baird, JK   +8 more
openaire   +4 more sources

Relating mutant genotype to phenotype via quantitative behavior of the NADPH redox cycle in human erythrocytes. [PDF]

PLoS ONE, 2010
The NADPH redox cycle plays a key role in antioxidant protection of human erythrocytes. It consists of two enzymes: glucose-6-phosphate dehydrogenase (G6PD) and glutathione reductase.
Pedro M B M Coelho, Armindo Salvador, Michael A Savageau   +2 more
doaj   +1 more source

Protective effect of Mediterranean-type glucose-6-phosphate dehydrogenase deficiency against Plasmodium vivax malaria

eLife, 2021
X-linked glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy. The severe Mediterranean variant (G6PD Med) found across Europe and Asia is thought to confer protection against malaria, but its effect is unclear.
Ghulam R Awab, Fahima Aaram, Natsuda Jamornthanyawat, Kanokon Suwannasin, Watcharee Pagornrat, James A Watson, Charles J Woodrow, Arjen M Dondorp, Nicholas PJ Day, Mallika Imwong, Nicholas J White   +10 more
doaj   +1 more source

Correction to ‘Genotyping of Malaysian G6PD-deficient neonates by reverse dot blot flow-through hybridisation’ [PDF]

Journal of Human Genetics, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
M F, Alina, R Z, Azma, J, Norunaluwar, I, Azlin, A J, Darnina, F C, Cheah, A R, Noor-Farisah, A A, Siti-Hawa, X R K, Danny, Noor-Fadzilah, Zulkifli, O, Ainoon   +10 more
openaire   +2 more sources

Combined DNA extraction and antibody elution from filter papers for the assessment of malaria transmission intensity in epidemiological studies. [PDF]

, 2013
BACKGROUND: Informing and evaluating malaria control efforts relies on knowledge of local transmission dynamics. Serological and molecular tools have demonstrated great sensitivity to quantify transmission intensity in low endemic settings where the ...
Baidjoe, Amrish, Bousema, Teun, Cox, Jonathan, Drakeley, Chris, Grignard, Lynn, Kariuki, Simon, Makori, Euniah, Osoti, Victor, Ploemen, Ivo, Sauerwein, Robert, Shagari, Shehu, Stevenson, Jennifer, Stone, Will, Sutherland, Colin   +13 more
core   +3 more sources

Nutritional status of young children with inherited blood disorders in western Kenya. [PDF]

, 2014
To determine the association between a range of inherited blood disorders and indicators of poor nutrition, we analyzed data from a population-based, cross-sectional survey of 882 children 6–35 months of age in western Kenya.
Ruth, LJ, Suchdev, PS, Sullivan, KM, Tsang, BL, Williams, TN   +4 more
core   +1 more source

Incorporating genotyping to identify patients with G6PD deficiency

, 2021
Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common X-linked enzyme disorder associated with hemolytic anemia after exposure to certain medications or foods. Activity testing is the gold standard for detecting G6PD deficiency; however, this test is affected by various hematologic parameters.
Sarah Morris, Kristine Crews, Randall Hayden, Clifford Takemoto, Wenjian Yang, Donald Baker, Ulrich Broeckel, Mary Relling, Cyrine Haidar   +8 more
openaire   +1 more source

African glucose-6-phosphate dehydrogenase alleles associated with protection from severe malaria in heterozygous females in Tanzania [PDF]

, 2015
X-linked Glucose-6-phosphate dehydrogenase (G6PD) A- deficiency is prevalent in sub-Saharan Africa populations, and has been associated with protection from severe malaria.
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core   +7 more sources