Results 11 to 20 of about 4,171 (132)

Associations between red cell polymorphisms and Plasmodium falciparum infection in the middle belt of Ghana. [PDF]

PLoS ONE, 2014
BACKGROUND: Red blood cell (RBC) polymorphisms are common in malaria endemic regions and are known to protect against severe forms of the disease. Therefore, it is important to screen for these polymorphisms in drugs or vaccines efficacy trials.
Nicholas Amoako, Kwaku Poku Asante, George Adjei, Gordon A Awandare, Langbong Bimi, Seth Owusu-Agyei   +5 more
doaj   +1 more source

Performance of the CareStart™ G6PD deficiency screening test, a point-of-care diagnostic for primaquine therapy screening. [PDF]

PLoS ONE, 2011
Development of reliable, easy-to-use, rapid diagnostic tests (RDTs) to detect glucose-6-phosphate dehydrogenase (G6PD) deficiency at point of care is essential to deploying primaquine therapies as part of malaria elimination strategies. We assessed a kit
Saorin Kim, Chea Nguon, Bertrand Guillard, Socheat Duong, Sophy Chy, Sarorn Sum, Sina Nhem, Christiane Bouchier, Magali Tichit, Eva Christophel, Walter R J Taylor, John Kevin Baird, Didier Menard   +12 more
doaj   +1 more source

Molecular characterization of G6PD mutations reveals the high frequency of G6PD Aures in the Lao Theung population

Malaria Journal, 2021
Background The prevalence and genotypes of G6PD deficiency vary worldwide, with higher prevalence in malaria endemic areas. The first-time assessment of G6PD deficiency prevalence and molecular characterization of G6PD mutations in the Lao Theung ...
Amkha Sanephonasa, Chalisa Louicharoen Cheepsunthorn, Naly Khaminsou, Onekham Savongsy, Issarang Nuchprayoon, Kamonlak Leecharoenkiat   +5 more
doaj   +1 more source

Relating mutant genotype to phenotype via quantitative behavior of the NADPH redox cycle in human erythrocytes. [PDF]

PLoS ONE, 2010
The NADPH redox cycle plays a key role in antioxidant protection of human erythrocytes. It consists of two enzymes: glucose-6-phosphate dehydrogenase (G6PD) and glutathione reductase.
Pedro M B M Coelho, Armindo Salvador, Michael A Savageau   +2 more
doaj   +1 more source

Protective effect of Mediterranean-type glucose-6-phosphate dehydrogenase deficiency against Plasmodium vivax malaria

eLife, 2021
X-linked glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy. The severe Mediterranean variant (G6PD Med) found across Europe and Asia is thought to confer protection against malaria, but its effect is unclear.
Ghulam R Awab, Fahima Aaram, Natsuda Jamornthanyawat, Kanokon Suwannasin, Watcharee Pagornrat, James A Watson, Charles J Woodrow, Arjen M Dondorp, Nicholas PJ Day, Mallika Imwong, Nicholas J White   +10 more
doaj   +1 more source

Genotypic and phenotypic characterization of glucose-6-phosphate dehydrogenase (G6PD) deficiency in Guangzhou, China

Human Genomics, 2023
Background G6PD deficiency is a common inherited disorder worldwide and has a higher incidence rate in southern China. Many variants of G6PD result from point mutations in the G6PD gene, leading to decreased enzyme activity.
Ziyan Li, Zhenyi Huang, Yanxia Liu, Yunshan Cao, Yating Li, Yanping Fang, Meiying Huang, Zixi Liu, Lijuan Lin, Lingxiao Jiang   +9 more
doaj   +1 more source

Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials

Malaria Journal, 2011
Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency is common in populations living in malaria endemic areas. G6PD genotype and phenotype were determined for malaria patients enrolled in the chlorproguanil-dapsone-artesunate (CDA) phase III ...
Duparc Stephan, Pamba Allan, Carter Nick, Waitumbi John N   +3 more
doaj   +1 more source

Prevalence and distribution of G6PD deficiency: implication for the use of primaquine in malaria treatment in Ethiopia

Malaria Journal, 2019
Background G6PD enzyme deficiency is a common enzymatic X-linked disorder. Deficiency of the G6PD enzyme can cause free radical-mediated oxidative damage to red blood cells, leading to premature haemolysis.
Eugenia Lo, Daibin Zhong, Beka Raya, Kareen Pestana, Cristian Koepfli, Ming-Chieh Lee, Delenasaw Yewhalaw, Guiyun Yan   +7 more
doaj   +1 more source

Glucose-6-phosphate dehydrogenase mutations in malaria endemic area of Thailand by multiplexed high‐resolution melting curve analysis

Malaria Journal, 2021
Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency, the most common enzymopathy in humans, is prevalent in tropical and subtropical areas where malaria is endemic.
Usa Boonyuen, Duantida Songdej, Sasipa Tanyaratsrisakul, Suparat Phuanukoonnon, Kamonwan Chamchoy, Aun Praoparotai, Phonchanan Pakparnich, Sirapapha Sudsumrit, Thomas Edwards, Christopher T. Williams, Rachel L. Byrne, Emily R. Adams, Mallika Imwong   +12 more
doaj   +1 more source

Genetic Variants of Glucose-6-Phosphate Dehydrogenase and Their Associated Enzyme Activity: A Systematic Review and Meta-Analysis

Pathogens, 2022
Low glucose-6-phosphate dehydrogenase enzyme (G6PD) activity is a key determinant of drug-induced haemolysis. More than 230 clinically relevant genetic variants have been described.
Daniel A. Pfeffer, Ari Winasti Satyagraha, Arkasha Sadhewa, Mohammad Shafiul Alam, Germana Bancone, Yap Boum, Marcelo Brito, Liwang Cui, Zeshuai Deng, Gonzalo J. Domingo, Yongshu He, Wasif A. Khan, Mohammad Golam Kibria, Marcus Lacerda, Didier Menard, Wuelton Monteiro, Sampa Pal, Sunil Parikh, Arantxa Roca-Feltrer, Michelle Roh, Mahmoud M. Sirdah, Duoquan Wang, Qiuying Huang, Rosalind E. Howes, Ric N. Price, Benedikt Ley   +25 more
doaj   +1 more source