Results 81 to 90 of about 19,960,264 (249)

Transitions and multistability in macroevolutionary dynamics of large mammals [PDF]

Acta Palaeontologica Polonica
On multi-million-year timescales, the climate system of the Earth exhibits complex wandering behaviour. We investigate the evolutionary impacts of long-term climate change by analysing the dynamics of Cenozoic mammal evolution, looking for the presence ...
Simona Bekeraitė, Robertas Stankevič, Ivona Juchnevičiūtė, Kristian Agasøster Haaga, Andrej Spiridonov   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Reverend J. G. Robinson letter to Warren G. Harding, February 21, 1920

, 1920
In this letter dated February 21, 1920, Reverend J. G. Robinson writes to Senator Warren G. Harding offering his help with campaign strategy planning for winning African American votes and support from areas that will elect African American delegates to ...
Robinson, J. G.
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Legitimación procesal infantil y acceso a la justicia en contextos de inacción parental [PDF]

En primer lugar, y antes de adentrarnos en el análisis del fallo, es fundamental señalar que dentro de los grupos vulnerables se encuentran niñas, niños y adolescentes (NNA), quienes requieren una especial atención y protección para garantizar el pleno ...
Romero, Analía Julieta
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

“El equilibro entre las garantías del imputado y la revictimización del niño” [PDF]

Para la presente tesis final de grado, elegí: “Recurso de hecho deducido por la querella en la causa G. G. E. s/ abuso sexual agravado por la convivencia y el parentesco” debido a mi interés por analizar las respuestas del sistema judicial frente a los ...
Bustos, Carlos Isidro
core  

Diffusion of activated ATM explains γH2AX and MDC1 spread beyond the DNA damage site

iScience
Summary: During DNA repair, ATM-induced H2AX histone phosphorylation and MDC1 recruitment spread megabases beyond the damage site. While loop extrusion has been suggested to drive this spread, the underlying mechanism remains unclear.
Georgi Danovski, Greta Panova, Bradley Keister, Georgi Georgiev, Aleksandar Atemin, Sonya Uzunova, Rumen Stamatov, Petar-Bogomil Kanev, Radoslav Aleksandrov, Krastan B. Blagoev, Stoyno S. Stoynov   +10 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Adopción. Entrega directa y el interés superior del niño. [PDF]

La presente nota a fallo tratará sobre los autos “Recurso de hecho deducido por E. L. G. K. y A. C. G. en la causa G., A. C. y otro s/ guarda con fines de adopción”, para decidir sobre su procedencia. Con fecha 20 de abril de 2023.
Canal, Soledad Patricia
core