Effects of ganglioside G(M1) and erythropoietin on spinal cord lesions in rats: functional and histological evaluations [PDF]
Clinics, 2016 OBJECTIVE: To evaluate the functional and histological effects of ganglioside G(M1) and erythropoietin after experimental spinal cord contusion injury.
Raphael Martus Marcon +4 more
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Cytotoxic Effects of G Ganglioside and Amyloid β-Peptide on Mouse Embryonic Neural Stem Cells [PDF]
ASN Neuro, 2010 AD (Alzheimer's disease) is a neurodegenerative disease and the most common form of dementia. One of the pathological hallmarks of AD is the aggregation of extracellular Aβs (amyloid β-peptides) in senile plaques in the brain.
Makoto Yanagisawa +2 more
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AAV-Mediated Gene Delivery in Adult GM1-Gangliosidosis Mice Corrects Lysosomal Storage in CNS and Improves Survival [PDF]
, 2010 Background: GM1-gangliosidosis is a glycosphingolipid (GSL) lysosomal storage disease caused by a genetic deficiency of acid β-galactosidase (βgal), which results in the accumulation of GM1-ganglioside and its asialo-form (GA1) primarily in the CNS.
Baek, Rena C. +7 more
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THE EFFECT OF MONOSIALOGANGLYOSIDE (GM-1) ADMINISTRATION IN SPINAL CORD INJURY [PDF]
Acta Ortopédica Brasileira, 2016 Objective: To evaluate the effect of monosialoganglioside (GM-1) in spinal cord trauma patients seen in our service who have not been treated with methylprednisolone. Methods: Thirty patients with acute spinal cord trauma were randomly divided into two
TARCÍSIO ELOY PESSOA BARROS FILHO +4 more
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C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy [PDF]
, 2016 Introduction Guillain-Barré syndrome (GBS) is an autoimmune disease that results in acute paralysis through inflammatory attack on peripheral nerves, and currently has limited, non-specific treatment options.
Barrie, Jennifer A. +8 more
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PLoS Computational Biology, 2012 As an advanced approach to identify suitable targeting molecules required for various diagnostic and therapeutic interventions, we developed a procedure to devise peptides with customizable features by an iterative computer-assisted optimization strategy.
Niels Röckendorf +2 more
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Landmark-Based Registration of Curves via the Continuous Wavelet Transform [PDF]
, 2006 This paper is concerned with the problem of the alignment of multiple sets of curves. We analyze two real examples arising from the biomedical area for which we need to test whether there are any statistically significant differences between two subsets ...
Bigot, Jérémie
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Exosomes promote pre-metastatic niche formation in ovarian cancer. [PDF]
, 2019 Ovarian cancer is one of the most common gynecological malignancies. Upon initial diagnosis, the majority of patients present with widespread metastatic growth within the peritoneal cavity. This metastatic growth occurs in stages, with the formation of a
Dean, Dylan C +4 more
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The B subunit of Escherichia coli heat-labile toxin alters the development and antigen-presenting capacity of dendritic cells [PDF]
, 2015 Escherichia coli’s heat-labile enterotoxin (Etx) and its non-toxic B subunit (EtxB) have been characterized as adjuvants capable of enhancing T cell responses to co-administered antigen.
Griffiths, Kristin L. +4 more
core +1 more source
Coluna/Columna, 2011 OBJETIVO: Avaliar a eficácia do GM1, administrado por via intraperitoneal, após lesão medular experimental em ratos. MÉTODOS: Foram utilizados 20 ratos da raça Wistar machos, adultos jovens, com média de idade de 20 semanas, pesando em torno de 350 g ...
Fabiano Inácio de Souza +2 more
doaj +1 more source