Results 21 to 30 of about 11,803,234 (178)

Ultrastructural localization of cell membrane G _M1 ganglioside by cholera toxin [PDF]

Proceedings of the National Academy of Sciences, 1977
An immunoelectron microscopic method is described for sensitive high-resolution visualization of tissuebound cholera toxin. The principle is to incubate cells or tissue sections with toxin and then to localize the bound toxin with toxin-specific peroxidase (donor:hydrogen-peroxide oxidoreductase; EC 1.11.1.7)-conjugated antibody ...
H A, Hansson, J, Holmgren, L, Svennerholm   +2 more
openaire   +2 more sources

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology. [PDF]

Adv Sci (Weinh)
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Pilotto F, Toth TD, Bond S, Schmitz A, Diab R, Tenlep SYN, Mooney B, Erni S, Schobesberger M, Scheidegger O, Peitsch C, Saxena S.   +11 more
europepmc   +2 more sources

Incorporation of Novel Synthetic Glycolipids in Liposomal Nanoparticles Affects Opsonization and In Vivo Clearance

Angewandte Chemie, Volume 138, Issue 28, 6 July 2026.
We prepared five glycosylated liposomal nanoparticles (G‐LNPs) to investigate the role of glycosylation and protein corona in modulating the in vivo behavior of G‐LNPs. We show that IgG and complement C3 adsorption enhanced liposomal nanoparticle clearance, with IgG promoting subsequent C3 binding.
Yingjie Yu, Xuehan Li, Yu Gao, Shijia Tao, Xiaofei Li, Lemei Zhao, Wenshuai Han, Hao Fan, Ying Qiu, Man Wang, Luying Zhou, Xiaoyan Fang, Wenhua Yang, Haiyang Zhang, Volker Mailänder, Daniel Crespy, Katharina Landfester, Shuai Jiang, Xiangzhao Mao   +18 more
wiley   +2 more sources

Neuromuscular synaptic function in mice lacking major subsets of gangliosides [PDF]

, 2008
Gangliosides are a family of sialylated glycosphingolipids enriched in the outer leaflet of neuronal membranes, in particular at synapses. Therefore, they have been hypothesized to play a functional role in synaptic transmission.
Furukawa, K., Plomp, J.J., Willison, H.J., Willison, HJ, Verschuuren, JJ, Todorov, B, Furukawa, K, Jacobs, B.C., Zitman, FMP, Todorov, B., Zitman, F.M.P., Verschuuren, J.J., Plomp, JJ   +12 more
core   +1 more source

G_M1 ganglioside ELISA demonstrates functional receptor binding by the TcpF-A2-CTB chimera and CTB.

, 2013
Several dilutions from stock solutions containing equimolar amounts of TcpF chimera, CTB, or TcpF were loaded onto ELISA plates coated with GM1 ganglioside and serially diluted.
Gregory A. Price (312411), Randall K. Holmes (171068)   +1 more
core   +1 more source

Synthesis of a Fluorescent Ganglioside G_M1 Derivative and Screening of a Synthetic Peptide Library for G_M1 Binding Sequence Motifs [PDF]

Bioconjugate Chemistry, 2007
A ganglioside GM1 probe bearing a dark-red fluorescent dye at the sphingosine moiety of the molecule was prepared by a convenient one-pot synthesis. The labeled GM1 permitted the detection of the natural ganglioside GM1 ligand Escherichia coli heat-labile enterotoxin subunit B (EtxB) in picomole quantities on a solid support. When an epitope mapping of
Rockendorf, Niels, Bade, Steffen, Hirst, Timothy, Gorris, Hans H., Frey, Andreas   +4 more
openaire   +3 more sources

Synthesis of tri- and tetrasaccharide haptens related to the Asialo forms of the gangliosides G_M2 and G_M1 [PDF]

Canadian Journal of Chemistry, 1984
Synthesis of βDGalNAc(1→4)βDGal(1→4)βDGlc—O(CH2)8COOCH3 (21) and βDGal(1→3)βDGalNAc(1→4)βDGal(1→4)βDGlc—O(CH2)8COOCH3 (33) are presented starting from βDGal(1→4)βDGlc—O(CH2)8COOCH3 (1) and D-galactose. Improvements in the preparations of D-galactal triacetate (7) and tri-O-acetyl-2-azido-2-deoxy-α-D-galactopyranosyl bromide (11) are reported.
Subramaniam Sabesan, Raymond U. Lemieux
openaire   +1 more source

Analysis of binding activity and immunoreactivity of the TcpA-A2-CTB chimera and the CTB and TcpA proteins by ganglioside G_M1 ELISA assays.

, 2014
Equimolar amounts of each protein were loaded and serially diluted into wells of the ganglioside GM1-coated ELISA plates or control plates without bound ganglioside GM1 (-GM1).
Gregory A. Price (312411), Randall K. Holmes (171068)   +1 more
core   +1 more source

Locations and Reorientations of Multi-Ring-Fused 2-Pyridones in Ganglioside G_M1 Micelles

Langmuir, 2011
Fluorescent multi-ring-fused 2-pyridones, with chemical resemblance to other biologically active 2-pyridone systems, were solubilized in spherical micelles formed by the ganglioside G(M1) and studied with respect to their spatial localization and rotational mobility.
Sachl, Radek, Rosenbaum, Erik, Sellstedt, Magnus, Almqvist, Fredrik, Johansson, Lennart B-Å   +4 more
openaire   +4 more sources

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source