Results 41 to 50 of about 5,214 (181)
Acute buspirone abolishes the expression of behavioral dopaminergic supersensitivity in mice [PDF]
, 2002 Previous studies have shown that rats withdrawn from long-term treatment with dopamine receptor blockers exhibit dopaminergic supersensitivity, which can be behaviorally evaluated by enhanced general activity observed in an open-field.
Alcântara, F.b. +4 more
core +2 more sources
Increased Concentration of GM1-Ganglioside in Cerebrospinal Fluid in Dogs with GM1- and GM2-Gangliosidoses and its Clinical Application for Diagnosis [PDF]
Journal of Veterinary Diagnostic Investigation, 2004 GM1- and GM2-gangliosidoses are lethal lysosomal diseases that are caused by a defect of acid hydrolases, resulting in the intralysosomal accumulation of the specific physiological substrates, GM1- and GM2-gangliosides, respectively. In the present study a method for the diagnosis of canine GM1-gangliosidosis was established using canine cerebrospinal
Hiroyuki, Satoh +4 more
openaire +2 more sources
The FEBS Journal, EarlyView.The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs +7 more
wiley +1 more source
Drugs in early clinical development for the treatment of osteosarcoma [PDF]
, 2015 Introduction: Osteosarcomas are the main malignant primary bone tumours found in children and young adults. Conventional treatment is based on diagnosis and resection surgery, combined with polychemotherapy.
Allen B +28 more
core +3 more sources
European Journal of Immunology, Volume 56, Issue 5, May 2026.IC‐mediated inflammatory response—the NLRP3 inflammasome activation, cytokine secretion, and antigen presentation depend on SYK signalling pathways in primary murine microglia. ABSTRACT Viral infections might trigger systemic inflammatory responses characterised by inflammasome activation and cytokine release, driven by immune complex (IC) formation ...
Kristina Mašalaitė +3 more
wiley +1 more source
Localization patterns of the ganglioside G M1 in human sperm are indicative of male fertility and independent of traditional semen measures [PDF]
Molecular Reproduction and Development, 2017 Semen analysis lacks a functional component and best identifies extreme cases of infertility. The ganglioside GM1 is known to have functional roles during capacitation and acrosome exocytosis. Here, we assessed whether GM1 localization patterns (Cap-Score™) correspond with male fertility in different settings: Study 1 involved couples pursuing assisted
Cristina Cardona +9 more
openaire +2 more sources
Cancer immunology and canine malignant melanoma: a comparative review [PDF]
, 2016 Oral canine malignant melanoma (CMM) is a spontaneously occurring aggressive tumour with relatively few medical treatment options, which provides a suitable model for the disease in humans.
Atherton, Matthew J. +3 more
core +1 more source
Advanced NanoBiomed Research, Volume 6, Issue 4, April 2026.This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari +5 more
wiley +1 more source
MedComm, Volume 7, Issue 4, April 2026.CAR‐T cell therapy in systemic rheumatic diseases and autoimmune disorders. (This figure was created using BioRender.com.) ABSTRACT Chimeric antigen receptor T (CAR‐T) cell therapy, originally developed for hematologic malignancies, has emerged as a transformative candidate for systemic rheumatic diseases and autoimmune disorders (AIDs).
Zhidan Fan, Li Zhang, Haiguo Yu
wiley +1 more source
The Level of NMDA Receptor in the Membrane Modulates Amyloid-β Association and Perforation [PDF]
, 2016 Alzheimer’s disease is a neurodegenerative disorder that affects mostly the elderly. The main histopathological markers are the senile plaques formed by amyloid-β peptide (Aβ) aggregates that can perforate the plasma membrane of cells, increasing the ...
Aguayo, Luis G +4 more
core +1 more source