Results 61 to 70 of about 5,214 (181)

Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection [PDF]

, 2015
Dendritic cells can capture and transfer retroviruses in vitro across synaptic cell-cell contacts to uninfected cells, a process called trans-infection. Whether trans-infection contributes to retroviral spread in vivo remains unknown.
Beloor, Jagadish, Bjorkman, Pamela J., Brehm, Michael A., Greiner, Dale L., Herrmann, Christin, Kumar, Priti, Ladinsky, Mark S., Mempel, Thorsten R., Motamedi, Nasim, Mothes, Walther, Murooka, Thomas T., Pi, Ruoxi, Sewald, Xaver, Shultz, Leonard D., Uchil, Pradeep D.   +14 more
core   +1 more source

Receptor‐mediated interaction of ricin with the lipid bilayer of ganglioside G_M1‐liposomes [PDF]

FEBS Letters, 1987
The interaction of ricin with ganglioside GM1 or glycoprotein containing liposomes was investigated. At neutral pH, ricin bound to galactose moieties on the surface of the liposomes to form ricin‐liposome complexes, but did not associate with their lipid bilayers.
Utsumi, Toshihiko, Aizono, Yasuo, Funatsu, Gunki   +2 more
openaire   +2 more sources

CD169+ Macrophage‐Targeted Immunomodulator to Restore Phagocytic Function and Enhance Antigen Presentation for Lymphatic Metastasis Eradication

Advanced Science, Volume 13, Issue 6, 30 January 2026.
A CD169+ macrophage‐targeted immunomodulator (G‐LNP@S‐D) is developed to co‐deliver a SHP2 inhibitor and STING agonist, thereby restoring phagocytic function, enhancing antigen presentation by CD169+ macrophages, and promoting T cell priming to eradicate lymphatic metastasis.
Xiayun Chen, Lichong Lu, Yibin Liu, Ziqi Liang, Jianqiao Li, Zhouchuan Shao, Youzhi Tang, Jianhua Zou, Shiying Li, Xiaoyuan Chen   +9 more
wiley   +1 more source

MARCH1 protects the lipid raft and tetraspanin web from MHCII proteotoxicity in dendritic cells [PDF]

, 2018
Dendritic cells (DCs) produce major histocompatibility complex II (MHCII) in large amounts to function as professional antigen presenting cells. Paradoxically, DCs also ubiquitinate and degrade MHCII in a constitutive manner.
Anderson, Anderson, Baravalle, Bartee, Berditchevski, Björkholm, Charrin, Charrin, Chen, Chyi-Song Hsieh, Corcoran, De Gassart, Giudicelli, Golshayan, Hanada, Haribhai, Heather Pua, Hiltbold, Hoffmann, Hsieh, Hsieh, Jaehak Oh, Jeoung-Sook Shin, Justin S.A. Perry, Kato, Klein, Kondoh, Kropshofer, Kurts, Lehner, Matsuki, Metz, Mottet, Nicole Irgens-Möller, Odintsova, Oh, Oh, Ohmura-Hoshino, Perry, Powrie, Roy, Sachl, Sala-Valdés, Satoshi Ishido, Sharom, Shin, Simons, Stritesky, Unternaehrer, van Niel, Veerapathran, Walseng, Yamaji, Yamazaki, Zimmerman   +54 more
core   +2 more sources

Antigen binding to G_M1 ganglioside results in delayed presentation: minimal effects of G_M1 on presentation of antigens internalized via other pathways [PDF]

Immunology, 2002
SummaryPlasma membrane rafts are sphingolipid‐ and cholesterol‐rich patches that function as membrane trafficking and surface signalling regions. Ganglioside GM1 is an integral component of these microdomains, and Escherichia coli enterotoxin B subunit (EtxB) is a pentamer that binds with high affinity to GM1 resulting in GM1 cross‐linking.
Toufic O, Nashar, Zoe E, Betteridge, Richard N, Mitchell   +2 more
openaire   +2 more sources

Analysis of Protein and Lipid Dynamics Using Confocal Fluorescence Recovery After Photobleaching

Current Protocols, Volume 6, Issue 1, January 2026.
Abstract Fluorescence recovery after photobleaching (FRAP) is a powerful, versatile, and widely accessible tool to monitor molecular dynamics in living cells that can be performed using modern confocal microscopes. Although the basic principles of FRAP are simple, quantitative FRAP analysis requires careful experimental design, data collection, and ...
Charles A. Day, Lewis J. Kraft, Minchul Kang, Anne K. Kenworthy   +3 more
wiley   +1 more source

Lnc‐CHRM4‐2:1 Inhibits M2 Polarization and Efferocytosis of Macrophages by Downregulating MerTK and SLC2A1 in Rheumatoid Arthritis

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Objective Rheumatoid arthritis (RA) is a common chronic and systemic autoimmune disease. Long noncoding RNAs (lncRNAs) have been documented to play important roles in the pathogenesis of RA. This study is aimed to investigate the differentially expressed lncRNAs in RA and explore the underlying roles and mechanisms of RA‐specific lncRNAs.
Jinjin Chu, Jie Zang, Lili Zhang, Zhuojian Qu, Haibo Li, Chunjuan Yang, Jiamei Sun, Linlin Gai, Xuecheng Sun, Donghua Xu, Poorani Gurumallesh   +10 more
wiley   +1 more source

Sensory and motor neuronopathy in a patient with the A382P TDP-43 mutation [PDF]

, 2011
Patients with TARDBP mutations have so far been classified as ALS, sometimes with frontal lobe dysfunction. A 66-year-old patient progressively developed a severe sensory disorder, followed by a motor disorder, which evolved over nine years.
Jean-Philippe Camdessanché, Véronique V Belzil, Guillemette Jousserand, Guy A Rouleau, Christelle Créac'h, Philippe Convers, Jean-Christophe Antoine   +6 more
core   +1 more source

Immunotherapy for Leiomyosarcoma: Current Status and Perspectives

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Leiomyosarcoma (LMS), one of the soft‐tissue sarcomas (STSs), has a relatively higher risk of distant metastasis. This has resulted in current first‐line treatments still failing to deliver satisfactory outcomes, and the current treatment of LMS remains controversial and challenging.
Haoyue Qi, Hanxi Zhang, Qin Wang, Xiaolu Wang, Limei Min, Yingling Zhou, Baorui Liu, Rutian Li, Poorani Gurumallesh   +8 more
wiley   +1 more source

Parkinson's Disease and Cancer: Mechanistic Insights and Therapeutic Opportunities From Cancer Neuroscience

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Parkinson's disease (PD) and glioma are neurological disorders with distinct and even opposing mechanisms: α‐synuclein deposition and neuronal loss in PD versus glial cell malignancy in glioma. Despite these differences, their contrasting pathologies highlight multiple therapeutic targets.
Tianli Pan, Lin Yuan, Ruoyang Zhao, Liting Lu, Yinghao Zhi, Yuying Li, Min Wu, Yongye Huang   +7 more
wiley   +1 more source