Galectin-3-mediated glial crosstalk drives oligodendrocyte differentiation and (Re)myelination [PDF]
, 2018 Galectin-3 (Gal-3) is the only chimeric protein in the galectin family. Gal-3 structure comprises unusual tandem repeats of proline and glycine-rich short stretches bound to a carbohydrate-recognition domain (CRD).
Pasquini, Laura Andrea, Thomas, Laura
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Immune Dysregulation and Self-Reactivity in Schizophrenia: Do Some Cases of Schizophrenia Have an Autoimmune Basis? [PDF]
, 2005 Schizophrenia affects 1% of the world's population, but its cause remains obscure. Numerous theories have been proposed regarding the cause of schizophrenia, ranging from developmental or neurodegenerative processes or neurotransmitter abnormalities to ...
Abramsky O +21 more
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MedComm, Volume 6, Issue 10, October 2025.This review summarizes strategies to optimize lipid nanoparticles (LNPs) for improved targeting, endosomal escape, and safety. It highlights mRNA design, alternative delivery systems, and recent therapeutic advances across infectious diseases, cancer, and drug applications.
Xiaochi Li +7 more
wiley +1 more source
Reconstituting ring-rafts in bud-mimicking topography of model membranes. [PDF]
, 2014 During vesicular trafficking and release of enveloped viruses, the budding and fission processes dynamically remodel the donor cell membrane in a protein- or a lipid-mediated manner.
Jeon, Noo Li +11 more
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Monomer‐Micelle Transition of the Ganglioside GM1 and the Hydrolysis by Clostridium perfringens Neuraminidase [PDF]
European Journal of Biochemistry, 1979 The action of Clostridium perfringens neuraminidase on the ganglioside GM1 tritiated in the ceramide moiety was studied. The rates of hydrolysis of the GM1 ganglioside were determined from radioactivity in the neutral glycolipid product, which was separated from the substrate on DEAE‐Sephadex columns.In order to study the physical state of the ...
openaire +2 more sources
Exosomes: Versatile Nano Mediators of Immune Regulation. [PDF]
, 2019 One of many types of extracellular vesicles (EVs), exosomes are nanovesicle structures that are released by almost all living cells that can perform a wide range of critical biological functions.
Cacalano, Nicholas A +4 more
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A Cholera Toxin B-subunit Variant That Binds Ganglioside GM1 but Fails to Induce Toxicity
Journal of Biological Chemistry, 2001 Entry of cholera toxin (CT) into target epithelial cells and the induction of toxicity depend on CT binding to the lipid-based receptor ganglioside G(M1) and association with detergent-insoluble membrane microdomains, a function of the toxin's B-subunit. The B-subunits of CT and related Escherichia coli toxins exhibit a highly conserved exposed peptide
Rodighiero, Chiara +3 more
openaire +3 more sources
Evaluation and comparison of immunization level between recombinant proteins of binding subunit of entrotoxigenic Escherichia coli and botulinum toxin [PDF]
, 2013 زمینه و هدف: در میان عوامل باکتریایی، شایع ترین عامل بیماری اسهال، باکتری اشریشیاکلی انتروتوکسیژنیک است. زیر واحد LTB سم این باکتری قادر به ایجاد مصونیتی شش ماهه است.
Arefpour-Torabi, Mohammad Ali. +6 more
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Association of NaV1.8 with lipid rafts in DRG sensory neurons
, 2011 Voltage gated sodium channels (VGSCs) play a key role in the initiation and propagation of action potentials in neuronal cells. NaV1.8 is a Tetrodotoxin resistant VGSC expressed in nociceptors and underlies the majority of sodium currents during action
Pristera, Alessandro +1 more
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Adjuvant therapy of pancreatic cancer using monoclonal antibodies and immune response modifiers [PDF]
, 2018 Summary: Pancreatic cancer is a devastating disease with poor survival. At present, no effective adjuvant or palliative therapies are available. Unresponsiveness to chemotherapy, radiotherapy, and antihormonal treatment is one of the reasons that ...
Büchler, Markus +2 more
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