Results 51 to 60 of about 5,214 (181)
Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo [PDF]
, 2013 Background: Exosomes, small extracellular vesicles of endosomal origin, have been suggested to be involved in both the metabolism and aggregation of Alzheimer’s disease (AD)-associated amyloid β-protein (Aβ).
An, Kyongman +14 more
core +3 more sources
Advances in Hydrogel Tissue Engineering for Spinal Cord Injury Repair
Smart Medicine, Volume 5, Issue 2, April 2026.This review systematically introduces the pathological process of spinal cord injury (SCI) and the applications and biological roles of hydrogels in SCI repair. Emerging 4D printing and gene therapy strategies are also discussed. ABSTRACT Spinal cord injury (SCI), which is a severe complication of spinal fractures, often causes the dysfunction of the ...
Ruixing Shui +3 more
wiley +1 more source
A hidden Markov model for detecting confinement in single particle tracking trajectories [PDF]
, 2018 State-of-the-art single-particle tracking (SPT) techniques can generate long trajectories with high temporal and spatial resolution. This offers the possibility of mechanistically interpreting particle movements and behavior in membranes.
Burroughs, Nigel John, Slator, Paddy J.
core +1 more source
Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.Abstract Emerging evidence highlights the central role of peripheral immune–metabolic regulation in the pathogenesis of Alzheimer's disease and related dementias (ADRD). Among peripheral organs, the spleen has gained increasing attention as a critical immune–metabolic hub linking systemic homeostasis to central neurodegeneration.
Jingsi Yan +7 more
wiley +1 more source
Acta Ortopédica Brasileira, 2013 OBJETIVOS: Avaliar os efeitos de monossialogangliosídeos (GM1) administrados com laser por via transdérmica na recuperação da lesão da medula espinal de ratos. MÉTODOS: Quarenta ratos Wistar machos foram submetidos a contusão da medula espinal usando NYU
Fabiano Inácio de Souza +5 more
doaj
Microbial metabolites in tumor epigenetic regulation
iMeta, Volume 5, Issue 1, February 2026.The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang +31 more
wiley +1 more source
Effect of energy restriction and physical exercise intervention on phenotypic flexibility as examined by transcriptomics analyses of mRNA from adipose tissue and whole body magnetic resonance imaging [PDF]
, 2016 Overweight and obesity lead to changes in adipose tissue such as inflammation and reduced insulin sensitivity. The aim of this study was to assess how altered energy balance by reduced food intake or enhanced physical activity affect these processes.
Ahlin +64 more
core +1 more source
Small Science, Volume 6, Issue 2, February 2026.This review highlights recent advances in nanomedicine that enhance chimeric antigen receptor (CAR) T cell therapy against solid tumors. It discusses key barriers to CAR T cell efficacy and outlines nanotechnology‐based strategies to improve tumor targeting, remodel the immunosuppressive microenvironment, and integrate nanomaterials into CAR T cell ...
Stephen O’Rourke +3 more
wiley +1 more source
, 2011 Much of our knowledge regarding cancer immunotherapy has been derived from sarcoma models. However, translation of preclinical findings to bedside success has been limited in this disease, though several intriguing clinical studies hint at the potential ...
Gouw, Launce G +3 more
core +2 more sources
Model systems, lipid rafts, and cell membranes [PDF]
, 2000 Views of how cell membranes are organized are presently changing. The lipid bilayer that constitutes these membranes is no longer understood to be a homogeneous fluid.
Simons, Kai, Vaz, Winchil L. C.
core +1 more source