Effects of ganglioside G(M1) and erythropoietin on spinal cord lesions in rats: functional and histological evaluations [PDF]
Clinics, 2016 OBJECTIVE: To evaluate the functional and histological effects of ganglioside G(M1) and erythropoietin after experimental spinal cord contusion injury.
Raphael Martus Marcon +4 more
doaj +7 more sources
Cytotoxic Effects of G Ganglioside and Amyloid β-Peptide on Mouse Embryonic Neural Stem Cells [PDF]
ASN Neuro, 2010 AD (Alzheimer's disease) is a neurodegenerative disease and the most common form of dementia. One of the pathological hallmarks of AD is the aggregation of extracellular Aβs (amyloid β-peptides) in senile plaques in the brain.
Makoto Yanagisawa +2 more
doaj +5 more sources
Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology. [PDF]
Adv Sci (Weinh)Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Pilotto F +11 more
europepmc +2 more sources
Co-segregation of AMPA receptors with G(M1) ganglioside in synaptosomal membrane subfractions. [PDF]
Biochem J, 2010 Biochemical studies have suggested that certain synaptic proteins associate with lipid rafts to perform key functions within the synapse. However, variability in biochemical preparations raises questions as to which synaptic proteins actually associate with lipid rafts.
Cole AA, Dosemeci A, Reese TS.
europepmc +4 more sources
Intestinal Neutral Ceramidase Deficiency Triggers Regulatory T Cell Response via Gd3 to Protect the Host from Intestinal Inflammation. [PDF]
Adv Sci (Weinh)Deletion of ASAH2 in intestinal epithelial cells induces the accumulation of ganglioside GD3 via regulating ST8SIA1. GD3 is identified as the glycolipid ligand for the inhibitory receptor Siglec‐E on macrophages. GD3/Siglec‐E ligation polarizes macrophages and promotes the proliferation of colonic ST2+ T regulatory cells via the induction of IL‐33. The
Xu Z +11 more
europepmc +2 more sources
Synthesis of a Fluorescent Ganglioside G M1 Derivative and Sscreening of a Synthetic Peptide Library for G M1 Binding Sequence Motifs [PDF]
Bioconjugate Chemistry, 2015 A ganglioside GM1 probe bearing a dark-red fluorescent dye at the sphingosine moiety of the molecule was prepared by a convenient one-pot synthesis.
Bade, Steffen +4 more
core +4 more sources
Spatiotemporal Co-Delivery of Hydrogen and Magnesium via Microneedle Patches for Neuroinflammation Modulation After Spinal Cord Injury: A Multi-Modal In Vivo Study. [PDF]
SmallA spatiotemporal co‐delivery microneedle system (MN‐Mg) is developed for spinal cord injury repair. By generating hydrogen gas and magnesium ions in situ, this dual‐engine platform effectively scavenges ROS and modulates microglial polarization via the MAPK/AP‐1 signaling axis.
Wang H +13 more
europepmc +2 more sources
THE EFFECT OF MONOSIALOGANGLYOSIDE (GM-1) ADMINISTRATION IN SPINAL CORD INJURY [PDF]
Acta Ortopédica Brasileira, 2016 Objective: To evaluate the effect of monosialoganglioside (GM-1) in spinal cord trauma patients seen in our service who have not been treated with methylprednisolone. Methods: Thirty patients with acute spinal cord trauma were randomly divided into two
TARCÍSIO ELOY PESSOA BARROS FILHO +4 more
doaj +1 more source
Colocalization of the Ganglioside GM1 and Cholesterol Detected by Secondary Ion Mass Spectrometry [PDF]
Journal of the American Chemical Society, 2013 The characterization of the lateral organization of components in biological membranes and the evolution of this arrangement in response to external triggers remain a major challenge. The concept of lipid rafts is widely invoked; however, direct evidence of the existence of these ephemeral entities remains elusive.
Lozano, Monica M. +5 more
openaire +3 more sources
Conformation of the Oligosaccharide Chain of GM1 Ganglioside in a Carbohydrate-Enriched Surface [PDF]
Biophysical Journal, 1998 The solution structure of ganglioside G(M1) carbohydrate moiety at the surface of a 102-kDa lipid-modified-G(M1) micelle is investigated by high-resolution 1H-NMR in H2O. The micellar surface can be considered a cluster-like lateral distribution of the gangliosides, each single monomer being anchored in a carbohydrate-enriched model membrane matrix. 1H
P. Brocca, P. Berthault, S. Sonnino
openaire +3 more sources