Clinics, 2016 OBJECTIVE: To evaluate the functional and histological effects of ganglioside G(M1) and erythropoietin after experimental spinal cord contusion injury.
Raphael Martus Marcon +4 more
doaj +6 more sources
Cytotoxic Effects of G Ganglioside and Amyloid β-Peptide on Mouse Embryonic Neural Stem Cells
ASN Neuro, 2010 AD (Alzheimer's disease) is a neurodegenerative disease and the most common form of dementia. One of the pathological hallmarks of AD is the aggregation of extracellular Aβs (amyloid β-peptides) in senile plaques in the brain.
Makoto Yanagisawa +2 more
doaj +5 more sources
Colocalization of the Ganglioside GM1 and Cholesterol Detected by Secondary Ion Mass Spectrometry [PDF]
Journal of the American Chemical Society, 2013 The characterization of the lateral organization of components in biological membranes and the evolution of this arrangement in response to external triggers remain a major challenge. The concept of lipid rafts is widely invoked; however, direct evidence of the existence of these ephemeral entities remains elusive.
Lozano, Monica M. +5 more
openaire +4 more sources
Co-segregation of AMPA receptors with G(M1) ganglioside in synaptosomal membrane subfractions. [PDF]
Biochem J, 2010 Biochemical studies have suggested that certain synaptic proteins associate with lipid rafts to perform key functions within the synapse. However, variability in biochemical preparations raises questions as to which synaptic proteins actually associate with lipid rafts.
Cole AA, Dosemeci A, Reese TS.
europepmc +4 more sources
THE EFFECT OF MONOSIALOGANGLYOSIDE (GM-1) ADMINISTRATION IN SPINAL CORD INJURY [PDF]
Acta Ortopédica Brasileira, 2016 Objective: To evaluate the effect of monosialoganglioside (GM-1) in spinal cord trauma patients seen in our service who have not been treated with methylprednisolone. Methods: Thirty patients with acute spinal cord trauma were randomly divided into two
TARCÍSIO ELOY PESSOA BARROS FILHO +4 more
doaj +1 more source
Conformation of the Oligosaccharide Chain of GM1 Ganglioside in a Carbohydrate-Enriched Surface [PDF]
Biophysical Journal, 1998 The solution structure of ganglioside G(M1) carbohydrate moiety at the surface of a 102-kDa lipid-modified-G(M1) micelle is investigated by high-resolution 1H-NMR in H2O. The micellar surface can be considered a cluster-like lateral distribution of the gangliosides, each single monomer being anchored in a carbohydrate-enriched model membrane matrix. 1H
P. Brocca, P. Berthault, S. Sonnino
openaire +3 more sources
Condensing and Fluidizing Effects of Ganglioside GM1 on Phospholipid Films [PDF]
Biophysical Journal, 2008 Mixed monolayers of the ganglioside G(M1) and the lipid dipalmitoylphosphatidlycholine (DPPC) at air-water and solid-air interfaces were investigated using various biophysical techniques to ascertain the location and phase behavior of the ganglioside molecules in a mixed membrane.
Frey, Shelli L. +5 more
openaire +5 more sources
Interaction between ganglioside GM1 and diosgenin in langmuir monolayers at the air/water interface [PDF]
Scanning, 2013 SummaryThe interaction between ganglioside GM1 (GM1) and diosgenin (Dios) in mixed monolayers was investigated using surface pressure measurements and atomic force microscopy (AFM). The miscibility and stability of the mixed monolayer was evaluated both in a qualitative and quantitative way in terms of the excess mean molecular area (ΔAex), excess ...
Changchun, Hao +4 more
openaire +2 more sources
PLoS Computational Biology, 2012 As an advanced approach to identify suitable targeting molecules required for various diagnostic and therapeutic interventions, we developed a procedure to devise peptides with customizable features by an iterative computer-assisted optimization strategy.
Niels Röckendorf +2 more
doaj +1 more source
Increased Concentration of G M1 -Ganglioside in Cerebrospinal Fluid in Dogs with G M1 - and G M2 -Gangliosidoses and its Clinical Application for Diagnosis [PDF]
Journal of Veterinary Diagnostic Investigation, 2004 G M1 - and G M2 -gangliosidoses are lethal lysosomal diseases that are caused by a defect of acid hydrolases, resulting in the intralysosomal accumulation of the specific physiological substrates, G M1 - and G
Hiroyuki Satoh +4 more
openaire +1 more source