Results 11 to 20 of about 5,214 (181)

Condensing and Fluidizing Effects of Ganglioside GM1 on Phospholipid Films [PDF]

Biophysical Journal, 2008
Mixed monolayers of the ganglioside G(M1) and the lipid dipalmitoylphosphatidlycholine (DPPC) at air-water and solid-air interfaces were investigated using various biophysical techniques to ascertain the location and phase behavior of the ganglioside molecules in a mixed membrane.
Frey, Shelli L., Chi, Eva Y., Arratia, Cristóbal, Majewski, Jaroslaw, Kjaer, Kristian, Lee, Ka Yee C.   +5 more
openaire   +5 more sources

Interaction between ganglioside G_M1 and diosgenin in langmuir monolayers at the air/water interface [PDF]

Scanning, 2013
SummaryThe interaction between ganglioside GM1 (GM1) and diosgenin (Dios) in mixed monolayers was investigated using surface pressure measurements and atomic force microscopy (AFM). The miscibility and stability of the mixed monolayer was evaluated both in a qualitative and quantitative way in terms of the excess mean molecular area (ΔAex), excess ...
Changchun, Hao, Lei, Zhang, Runguang, Sun, Jing, Yang, Guangxiao, He   +4 more
openaire   +2 more sources

?2-Microglobulin Amyloid Fibril-Induced Membrane Disruption Is Enhanced by Endosomal Lipids and Acidic pH [PDF]

, 2014
Although the molecular mechanisms underlying the pathology of amyloidoses are not well understood, the interaction between amyloid proteins and cell membranes is thought to play a role in several amyloid diseases. Amyloid fibrils of ?2-microglobulin (?2m)
A Halle, A Ivankin, AD Petelska, AM Smith, B Boland, B Reed, C Cecchi, C Luquain, CJ Sarell, CL Bergstrom, CM Franzin, D Eisenberg, D Freeman, DE Lee, DP Smith, EE Ambroggio, Eric W. Hewitt, F Ferrone, F Gejyo, G van Meer, H Ohvo-Rekila, HD Gallala, HE White, I Benilova, IJ Morten, J Brotheru, J Brotherus, J Pan, J Villanueva, J Zimmerberg, JH Lee, JN Chebukati, JR Wherrett, JW Becker, K Berthelot, K Ditaranto, Kevin W. Tipping, L Milanesi, L Pieri, L Pieri, L Rajendran, M Arrasate, M Bostrom, M Bucciantini, M Duan, M Garcia-Garcia, M Stefani, MF Sciacca, MFM Engel, MFM Sciacca, MP Fogarty, MR Eftink, MY Porter, N Cremades, N Demaurex, N Liguori, Neil A. Ranson, NM Kad, NP Reynolds, Patrick van der Wel, Paul A. Beales, Rebecca Thompson, RF Chen, S Huterer, S Valleix, S Yamamoto, Sheena E. Radford, SL Myers, Sophia C. Goodchild, T Eichner, T Hayakawa, T Kobayashi, T Kobayashi, T Kobayashi, T Kobayashi, T Ookoshi, T Sheynis, T Umeda, Tania Sheynis, TE Frederick, TE Frederick, TL Williams, TL Williams, TP Knowles, TPJ Knowles, TR Jahn, TR Jahn, V Soura, VJ McParland, VN Uversky, Wei-Feng Xue, WF Xue, WF Xue, WF Xue, WF Xue, WF Xue, WG Wood, Y Hirakura, ZS Ji   +98 more
core   +15 more sources

C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy [PDF]

, 2016
Introduction Guillain-Barré syndrome (GBS) is an autoimmune disease that results in acute paralysis through inflammatory attack on peripheral nerves, and currently has limited, non-specific treatment options.
Barrie, Jennifer A., Cunningham, Madeleine E., Fewou, Simon N., Furukawa, Koichi, McGonigal, Rhona, Sankaranarayanan, Sethu, Willison, Hugh J., Yao, Denggao, Yednock, Ted A.   +8 more
core   +2 more sources

Molecular evolution of peptide ligands with custom-tailored characteristics for targeting of glycostructures.

PLoS Computational Biology, 2012
As an advanced approach to identify suitable targeting molecules required for various diagnostic and therapeutic interventions, we developed a procedure to devise peptides with customizable features by an iterative computer-assisted optimization strategy.
Niels Röckendorf, Markus Borschbach, Andreas Frey   +2 more
doaj   +1 more source

Heterogeneity of detergent-insoluble membranes from human intestine containing caveolin-1 and ganglioside G_M1 [PDF]

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2000
In intestinal epithelia, cholera and related toxins elicit a cAMP-dependent chloride secretory response fundamental to the pathogenesis of toxigenic diarrhea. We recently proposed that specificity of cholera toxin (CT) action in model intestinal epithelia may depend on the toxin's cell surface receptor ganglioside GM1.
K, Badizadegan, B L, Dickinson, H E, Wheeler, R S, Blumberg, R K, Holmes, W I, Lencer   +5 more
openaire   +2 more sources

The B subunit of Escherichia coli heat-labile toxin alters the development and antigen-presenting capacity of dendritic cells [PDF]

, 2015
Escherichia coli’s heat-labile enterotoxin (Etx) and its non-toxic B subunit (EtxB) have been characterized as adjuvants capable of enhancing T cell responses to co-administered antigen.
Griffiths, Kristin L., Hirst, Timothy R., Ji, Jing, Milburn, Peter J., O'Neill, Helen C.   +4 more
core   +1 more source

Concentrations of Ganglioside Type M1 and Immunoglobulin G in Colostrum Are Inversely Related to Bacterial Infection at Early Lactation in Cows [PDF]

Journal of Dairy Science, 2008
The levels of IgG and ganglioside type M1 in the colostrum of cows and heifers were analyzed to examine their utility in predicting acquisition of intramammary infection (IMI) during the first weeks postpartum. In general, high levels of IgG and ganglioside type M1 in cows were associated with lower new incidence of IMI, and linear discriminate ...
G, Leitner, O, Krifucks, S, Jacoby, Y, Lavi, N, Silanikove   +4 more
openaire   +2 more sources

Landmark-Based Registration of Curves via the Continuous Wavelet Transform [PDF]

, 2006
This paper is concerned with the problem of the alignment of multiple sets of curves. We analyze two real examples arising from the biomedical area for which we need to test whether there are any statistically significant differences between two subsets ...
Bigot, Jérémie
core   +4 more sources

Synthesis of N-Glycolylneuraminic Acid (Neu5Gc) and Its Glycosides. [PDF]

, 2019
Sialic acids constitute a family of negatively charged structurally diverse monosaccharides that are commonly presented on the termini of glycans in higher animals and some microorganisms.
Chen, Xi, Kooner, Anoopjit Singh, Yu, Hai   +2 more
core   +2 more sources