Intestinal Neutral Ceramidase Deficiency Triggers Regulatory T Cell Response via Gd3 to Protect the Host from Intestinal Inflammation. [PDF]
Adv Sci (Weinh)Deletion of ASAH2 in intestinal epithelial cells induces the accumulation of ganglioside GD3 via regulating ST8SIA1. GD3 is identified as the glycolipid ligand for the inhibitory receptor Siglec‐E on macrophages. GD3/Siglec‐E ligation polarizes macrophages and promotes the proliferation of colonic ST2+ T regulatory cells via the induction of IL‐33. The
Xu Z +11 more
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Colocalization of the Ganglioside GM1 and Cholesterol Detected by Secondary Ion Mass Spectrometry [PDF]
Journal of the American Chemical Society, 2013 The characterization of the lateral organization of components in biological membranes and the evolution of this arrangement in response to external triggers remain a major challenge. The concept of lipid rafts is widely invoked; however, direct evidence of the existence of these ephemeral entities remains elusive.
Lozano, Monica M. +5 more
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CD169+ Macrophage-Targeted Immunomodulator to Restore Phagocytic Function and Enhance Antigen Presentation for Lymphatic Metastasis Eradication. [PDF]
Adv Sci (Weinh)A CD169+ macrophage‐targeted immunomodulator (G‐LNP@S‐D) is developed to co‐deliver a SHP2 inhibitor and STING agonist, thereby restoring phagocytic function, enhancing antigen presentation by CD169+ macrophages, and promoting T cell priming to eradicate lymphatic metastasis.
Chen X +9 more
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Purified human liver acid β-
Biochemical Journal, 1977 Our studies with purified human liver acid beta-D-galactosidases (EC 3.2.1.23) indicate that 4-methylumbelliferyl beta-D-galactosidase and G(M1)-ganglioside beta-D-galactosidase activities are identical with lactosylceramidase II activity. Evidence for this includes co-purification of all enzyme activities by affinity chromatography to yield a single ...
A L, Miller, R G, Frost, J S, O'Brien
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Heterogeneity of detergent-insoluble membranes from human intestine containing caveolin-1 and ganglioside GM1 [PDF]
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2000 In intestinal epithelia, cholera and related toxins elicit a cAMP-dependent chloride secretory response fundamental to the pathogenesis of toxigenic diarrhea. We recently proposed that specificity of cholera toxin (CT) action in model intestinal epithelia may depend on the toxin's cell surface receptor ganglioside GM1.
K, Badizadegan +5 more
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Interaction between ganglioside GM1 and diosgenin in langmuir monolayers at the air/water interface [PDF]
Scanning, 2013 SummaryThe interaction between ganglioside GM1 (GM1) and diosgenin (Dios) in mixed monolayers was investigated using surface pressure measurements and atomic force microscopy (AFM). The miscibility and stability of the mixed monolayer was evaluated both in a qualitative and quantitative way in terms of the excess mean molecular area (ΔAex), excess ...
Changchun, Hao +4 more
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Condensing and Fluidizing Effects of Ganglioside GM1 on Phospholipid Films [PDF]
Biophysical Journal, 2008 Mixed monolayers of the ganglioside G(M1) and the lipid dipalmitoylphosphatidlycholine (DPPC) at air-water and solid-air interfaces were investigated using various biophysical techniques to ascertain the location and phase behavior of the ganglioside molecules in a mixed membrane.
Frey, Shelli L. +5 more
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Co-segregation of AMPA receptors with G(M1) ganglioside in synaptosomal membrane subfractions. [PDF]
Biochem J, 2010 Biochemical studies have suggested that certain synaptic proteins associate with lipid rafts to perform key functions within the synapse. However, variability in biochemical preparations raises questions as to which synaptic proteins actually associate with lipid rafts.
Cole AA, Dosemeci A, Reese TS.
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Ultrastructural localization of cell membrane G M1 ganglioside by cholera toxin [PDF]
Proceedings of the National Academy of Sciences, 1977 An immunoelectron microscopic method is described for sensitive high-resolution visualization of tissuebound cholera toxin. The principle is to incubate cells or tissue sections with toxin and then to localize the bound toxin with toxin-specific peroxidase (donor:hydrogen-peroxide oxidoreductase; EC 1.11.1.7)-conjugated antibody and enzyme
H A, Hansson +2 more
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Conformation of the oligosaccharide chain of G(M1) ganglioside in a carbohydrate-enriched surface. [PDF]
Biophys J, 1998 The solution structure of ganglioside G(M1) carbohydrate moiety at the surface of a 102-kDa lipid-modified-G(M1) micelle is investigated by high-resolution 1H-NMR in H2O. The micellar surface can be considered a cluster-like lateral distribution of the gangliosides, each single monomer being anchored in a carbohydrate-enriched model membrane matrix. 1H
Brocca P, Berthault P, Sonnino S.
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