Results 41 to 50 of about 5,197 (158)

A hidden Markov model for detecting confinement in single particle tracking trajectories [PDF]

, 2018
State-of-the-art single-particle tracking (SPT) techniques can generate long trajectories with high temporal and spatial resolution. This offers the possibility of mechanistically interpreting particle movements and behavior in membranes.
Burroughs, Nigel John, Slator, Paddy J.
core   +1 more source

Increased Concentration of G_M1-Ganglioside in Cerebrospinal Fluid in Dogs with G_M1- and G_M2-Gangliosidoses and its Clinical Application for Diagnosis [PDF]

Journal of Veterinary Diagnostic Investigation, 2004
GM1- and GM2-gangliosidoses are lethal lysosomal diseases that are caused by a defect of acid hydrolases, resulting in the intralysosomal accumulation of the specific physiological substrates, GM1- and GM2-gangliosides, respectively. In the present study a method for the diagnosis of canine GM1-gangliosidosis was established using canine cerebrospinal
Hiroyuki, Satoh, Osamu, Yamato, Tomoya, Asano, Masahiro, Yamasaki, Yoshimitsu, Maede   +4 more
openaire   +2 more sources

Ligand‐specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc‐containing glycan structures

The FEBS Journal, EarlyView.
The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs, Remi Hatinguais, Mike de Kok, R. J. Eveline Li, Tesfay M. Godefa, Victor L. J. L. Thijssen, Yvette van Kooyk, Sandra J. van Vliet   +7 more
wiley   +1 more source

Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection [PDF]

, 2015
Dendritic cells can capture and transfer retroviruses in vitro across synaptic cell-cell contacts to uninfected cells, a process called trans-infection. Whether trans-infection contributes to retroviral spread in vivo remains unknown.
Beloor, Jagadish, Bjorkman, Pamela J., Brehm, Michael A., Greiner, Dale L., Herrmann, Christin, Kumar, Priti, Ladinsky, Mark S., Mempel, Thorsten R., Motamedi, Nasim, Mothes, Walther, Murooka, Thomas T., Pi, Ruoxi, Sewald, Xaver, Shultz, Leonard D., Uchil, Pradeep D.   +14 more
core   +1 more source

Analysis of Protein and Lipid Dynamics Using Confocal Fluorescence Recovery After Photobleaching

Current Protocols, Volume 6, Issue 1, January 2026.
Abstract Fluorescence recovery after photobleaching (FRAP) is a powerful, versatile, and widely accessible tool to monitor molecular dynamics in living cells that can be performed using modern confocal microscopes. Although the basic principles of FRAP are simple, quantitative FRAP analysis requires careful experimental design, data collection, and ...
Charles A. Day, Lewis J. Kraft, Minchul Kang, Anne K. Kenworthy   +3 more
wiley   +1 more source

Cholera Toxin Subunit B as Adjuvant--An Accelerator in Protective Immunity and a Break in Autoimmunity [PDF]

, 2015
Cholera toxin subunit B (CTB) is the nontoxic portion of cholera toxin. Its affinity to the monosialotetrahexosylganglioside (GM1) that is broadly distributed in a variety of cell types including epithelial cells of the gut and antigen presenting cells ...
Stratmann, Thomas
core   +2 more sources

Parkinson's Disease and Cancer: Mechanistic Insights and Therapeutic Opportunities From Cancer Neuroscience

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Parkinson's disease (PD) and glioma are neurological disorders with distinct and even opposing mechanisms: α‐synuclein deposition and neuronal loss in PD versus glial cell malignancy in glioma. Despite these differences, their contrasting pathologies highlight multiple therapeutic targets.
Tianli Pan, Lin Yuan, Ruoyang Zhao, Liting Lu, Yinghao Zhi, Yuying Li, Min Wu, Yongye Huang   +7 more
wiley   +1 more source

Antigen binding to G_M1 ganglioside results in delayed presentation: minimal effects of G_M1 on presentation of antigens internalized via other pathways [PDF]

Immunology, 2002
SummaryPlasma membrane rafts are sphingolipid‐ and cholesterol‐rich patches that function as membrane trafficking and surface signalling regions. Ganglioside GM1 is an integral component of these microdomains, and Escherichia coli enterotoxin B subunit (EtxB) is a pentamer that binds with high affinity to GM1 resulting in GM1 cross‐linking.
Toufic O, Nashar, Zoe E, Betteridge, Richard N, Mitchell   +2 more
openaire   +2 more sources

Design Strategies for Novel Lipid Nanoparticle for mRNA Vaccine and Therapeutics: Current Understandings and Future Perspectives

MedComm, Volume 6, Issue 10, October 2025.
This review summarizes strategies to optimize lipid nanoparticles (LNPs) for improved targeting, endosomal escape, and safety. It highlights mRNA design, alternative delivery systems, and recent therapeutic advances across infectious diseases, cancer, and drug applications.
Xiaochi Li, Junli Li, Jiazheng Wei, Weixin Du, Cheng Su, Xiaobin Shen, Aihua Zhao, Miao Xu   +7 more
wiley   +1 more source

Monossialogangliosídeo transdérmico com laser no tratamento de lesão medular espinal de ratos Transdermal monosialoganglioside with laser in the treatment of spinal cord lesion in rats

Acta Ortopédica Brasileira, 2013
OBJETIVOS: Avaliar os efeitos de monossialogangliosídeos (GM1) administrados com laser por via transdérmica na recuperação da lesão da medula espinal de ratos. MÉTODOS: Quarenta ratos Wistar machos foram submetidos a contusão da medula espinal usando NYU
Fabiano Inácio de Souza, Alexandre Fogaça Cristante, Raphael Martus Marcon, Ricardo Ferreira, Gustavo Bispo dos Santos, Tarcísio Eloy Pessoa de Barros Filho   +5 more
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