Results 61 to 70 of about 5,197 (158)

Cancer stem cells: Bridging microenvironmental interactions and clinical therapy

Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.
Cancer stem cells (CSCs) drive tumor progression through their dynamic self‐renewal capacity, epigenetic plasticity, and drug resistance. These cells interact bi‐directionally with the tumor ecosystem to promote immunosuppressive reprogramming and metastatic spread.
Huiling Wang, Junshu Li, Fei Du, Hongxin Deng   +3 more
wiley   +1 more source

Acute buspirone abolishes the expression of behavioral dopaminergic supersensitivity in mice [PDF]

, 2002
Previous studies have shown that rats withdrawn from long-term treatment with dopamine receptor blockers exhibit dopaminergic supersensitivity, which can be behaviorally evaluated by enhanced general activity observed in an open-field.
Alcântara, F.b., Bibancos, Theo, Frussa-Filho, Roberto, Queiroz, Claudio Marcos Teixeira de, Yagüe, A.m.l.   +4 more
core   +2 more sources

Dissociation of cholera toxin functional regions after interaction with vesicles containing ganglioside G_M1 [PDF]

FEBS Letters, 1979
immunoelectron microscopy have provided evidence that the latent period may represent the time required for a redistribution of the toxin-receptor complexes in the cell membrane [ 10,111. Whether the active functional region penetrates the membrane through channels [ 121 or a change in the conformation of the toxin [ 131, resulting from the mobility of
Tomasi, Maurizio, Ausiello, Clara, Battistini, Angela, D'agnolo, Giuliano   +3 more
openaire   +2 more sources

Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo [PDF]

, 2013
Background: Exosomes, small extracellular vesicles of endosomal origin, have been suggested to be involved in both the metabolism and aggregation of Alzheimer’s disease (AD)-associated amyloid β-protein (Aβ).
An, Kyongman, Finan, Gina M, Jung, Jung Hoon, Kanmert, Daniel, Kim, Joung-Hun, Kim, Tae-Wan, Kim, Youngkyu, Klyubin, Igor, Lemere, Cynthia A, Lynch, Timothy, Mably, Alexandra J, O’Dowd, Sean T, Park, Joon Won, Rowan, Michael J, Walsh, Dominic M   +14 more
core   +3 more sources

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2021–2022

Mass Spectrometry Reviews, Volume 44, Issue 3, Page 213-453, May/June 2025.
Abstract The use of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this review is the 12th update of the original article published in 1999 and brings coverage of the literature to the end of 2022.
David J. Harvey
wiley   +1 more source

Low‐Intensity Pulsed Ultrasound Treatment Selectively Stimulates Senescent Cells to Promote SASP Factors for Immune Cell Recruitment

Aging Cell, Volume 24, Issue 5, May 2025.
The regulatory effects of low‐intensity pulsed ultrasound (LIPUS) stimulation in senescent cells are presented. LIPUS perturbs the membrane in senescent cells and induces intracellular reactive oxygen species via NOX4 expression. Consequently, secretion of senescence‐associated secretory phenotype, followed by migration of monocytes/macrophages and ...
HyeRan Gwak, Seoyoung Hong, Su Hyun Lee, In Woo Kim, Yonghan Kim, Hyungmin Kim, Ki Joo Pahk, So Yeon Kim   +7 more
wiley   +1 more source

Genetically Programmed Single‐Component Protein Hydrogel for Spinal Cord Injury Repair

Advanced Science, Volume 12, Issue 10, March 13, 2025.
A single‐component self‐assembling hydrogel using recombinant protein CsgA is developed for spinal cord injury repair. Gelation occurs through CsgA nanofibril entanglement, and the hydrogel is enhanced by fusing the GHK peptide. The CsgA‐GHK hydrogel modulates microglial M2 polarization, promotes neural stem cell differentiation, and reduces ...
Yi Wei, Xiaolin Zhou, Zhenhua Li, Qing Liu, Han Ding, Yunlong Zhou, Ruo‐feng Yin, Lifei Zheng   +7 more
wiley   +1 more source

Effect of energy restriction and physical exercise intervention on phenotypic flexibility as examined by transcriptomics analyses of mRNA from adipose tissue and whole body magnetic resonance imaging [PDF]

, 2016
Overweight and obesity lead to changes in adipose tissue such as inflammation and reduced insulin sensitivity. The aim of this study was to assess how altered energy balance by reduced food intake or enhanced physical activity affect these processes.
Ahlin, Bergmann, Bouloumie, Cancello, Capel, Carvalho, Chai, Clement, Duncan, Eguchi, Flegal, Frayn, Gleeson, Heymsfield, Hill, Hjorth, Hjorth, Kantartzis, Katz, Kawanishi, Kawanishi, Kelly, Kosteli, Kratz, Kuk, Lancaster, Langleite, Lee, Li, Lumeng, Luo, Magkos, Mifflin, Moreno-Navarrete, Ng, Norheim, Norheim, Oliveros, Paschos, Pi-Sunyer, Pontiroli, Pourteymour, Prieur, Reilly, Rodriguez, Samaan, Sattar, Schaffler, Schenk, Seijkens, Sell, Shimabukuro, Spencer, Stanford, Swift, Tam, Thomas, Thomas, Travers, Venkatasamy, Vieira, Vieira, Whitlock, Wysocki, Yki-Jarvinen   +64 more
core   +1 more source

Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase [PDF]

, 2018
A complex interplay of environmental factors impacts the metabolism of human cells, but neither traditional culture media nor mouse plasma mimic the metabolite composition of human plasma.
Abu-Remaileh, Monther, Cantor, Jason R., Freinkman, Elizaveta, Gao, Xin, Kanarek, Naama, Lewis, Caroline A., Louissaint, Abner, Sabatini, David   +7 more
core   +1 more source

Autophagy in Lysosomal Storage Disorders [PDF]

, 2012
Lysosomes are ubiquitous intracellular organelles that have an acidic internal pH, and play crucial roles in cellular clearance. Numerous functions depend on normal lysosomes, including the turnover of cellular constituents, cholesterol homeostasis ...
Ballabio, Andrea, Lieberman, Andrew P., Puertollano, Rosa, Raben, Nina, Slaugenhaupt, Susan Ann, Walkley, Steven U.   +5 more
core   +1 more source